Mouse Gene Cmah (ENSMUST00000167746.8) from GENCODE VM30
  Description: Mus musculus cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah), transcript variant 2, mRNA. (from RefSeq NM_001111110)
Gencode Transcript: ENSMUST00000167746.8
Gencode Gene: ENSMUSG00000016756.18
Transcript (Including UTRs)
   Position: mm39 chr13:24,511,403-24,661,268 Size: 149,866 Total Exon Count: 17 Strand: +
Coding Region
   Position: mm39 chr13:24,600,983-24,652,605 Size: 51,623 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2022-06-02 09:33:23

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr13:24,511,403-24,661,268)mRNA (may differ from genome)Protein (577 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsMGIPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; Short=CMP-N-acetylneuraminic acid hydroxylase; EC=; AltName: Full=CMP-N-acetylneuraminate monooxygenase; AltName: Full=CMP-Neu5Ac hydroxylase; AltName: Full=CMP-NeuAc hydroxylase; Flags: Precursor;
FUNCTION: Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N- glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells, except in brain.
CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O(2) + 2 H(+) = CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H(2)O.
COFACTOR: Binds 1 2Fe-2S cluster per subunit (Probable).
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum (Probable).
TISSUE SPECIFICITY: Expressed in all tissues tested, except in brain.
DISRUPTION PHENOTYPE: Mice do not synthesize N-glycolylneuraminic acid (Neu5Gc).
SIMILARITY: Belongs to the CMP-Neu5Ac hydroxylase family.
SIMILARITY: Contains 1 Rieske domain.
SEQUENCE CAUTION: Sequence=BAB91361.1; Type=Erroneous initiation; Sequence=BAB91362.1; Type=Erroneous initiation; Sequence=BAB91553.1; Type=Erroneous initiation;

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -142.20457-0.311 Picture PostScript Text
3' UTR -2039.607536-0.271 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017941 - Rieske_2Fe-2S

Pfam Domains:
PF00355 - Rieske [2Fe-2S] domain

ModBase Predicted Comparative 3D Structure on Q61419
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016491 oxidoreductase activity
GO:0030338 CMP-N-acetylneuraminate monooxygenase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process:
GO:0006054 N-acetylneuraminate metabolic process
GO:0046381 CMP-N-acetylneuraminate metabolic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum

-  Descriptions from all associated GenBank mRNAs
  BC028474 - Mus musculus cytidine monophospho-N-acetylneuraminic acid hydroxylase, mRNA (cDNA clone IMAGE:4160949).
AB061276 - Mus musculus CMAH mRNA for CMP-NeuAc hydroxylase, complete cds, major form of alternative splicing.
AB061277 - Mus musculus CMAH mRNA for CMP-NeuAc hydroxylase, complete cds, minor form of alternative splicing.
AK166486 - Mus musculus mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930028C23 product:cytidine monophospho-N-acetylneuraminic acid hydroxylase, full insert sequence.
BC055079 - Mus musculus cytidine monophospho-N-acetylneuraminic acid hydroxylase, mRNA (cDNA clone MGC:60630 IMAGE:30077348), complete cds.
AK145110 - Mus musculus mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830046F18 product:cytidine monophospho-N-acetylneuraminic acid hydroxylase, full insert sequence.
D21826 - Mus musculus mRNA for CMP-N-acetylneuraminic acid hydroxylase, complete cds.
AK083394 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:C920028L09 product:cytidine monophospho-N-acetylneuraminic acid hydroxylase, full insert sequence.
AK145199 - Mus musculus mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930017O18 product:cytidine monophospho-N-acetylneuraminic acid hydroxylase, full insert sequence.
AK040274 - Mus musculus 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430082J01 product:CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE homolog [Mus musculus], full insert sequence.
DQ705350 - Mus musculus piRNA piR-120672, complete sequence.
DQ555036 - Mus musculus piRNA piR-22148, complete sequence.
AB351249 - Mus musculus non-coding RNA, oocyte_piRNA2065, complete sequence.
AB339564 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA4765, complete sequence.
AB337529 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA2730, complete sequence.
AB351962 - Mus musculus non-coding RNA, oocyte_piRNA2778, complete sequence.
AB352525 - Mus musculus non-coding RNA, oocyte_piRNA3341, complete sequence.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6144 - CMP-N-glycoloylneuraminate biosynthesis

-  Other Names for This Gene
  Alternate Gene Symbols: CMAH_MOUSE, ENSMUST00000167746.1, ENSMUST00000167746.2, ENSMUST00000167746.3, ENSMUST00000167746.4, ENSMUST00000167746.5, ENSMUST00000167746.6, ENSMUST00000167746.7, NM_001111110, Q61419, Q7TMR9, Q8JZM9, uc011yxl.1, uc011yxl.2, uc011yxl.3, uc011yxl.4
UCSC ID: ENSMUST00000167746.8
RefSeq Accession: NM_001111110
Protein: Q61419 (aka CMAH_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.