Mouse Gene Cmah (ENSMUST00000167746.8) from GENCODE VM30
Description: Mus musculus cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah), transcript variant 2, mRNA. (from RefSeq NM_001111110)
Gencode Transcript: ENSMUST00000167746.8
Gencode Gene: ENSMUSG00000016756.18
Transcript (Including UTRs)
Position: mm39 chr13:24,511,403-24,661,268 Size: 149,866 Total Exon Count: 17 Strand: +
Position: mm39 chr13:24,600,983-24,652,605 Size: 51,623 Coding Exon Count: 14
Data last updated at UCSC: 2022-06-02 09:33:23
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; Short=CMP-N-acetylneuraminic acid hydroxylase; EC=18.104.22.168; AltName: Full=CMP-N-acetylneuraminate monooxygenase; AltName: Full=CMP-Neu5Ac hydroxylase; AltName: Full=CMP-NeuAc hydroxylase; Flags: Precursor;
FUNCTION: Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N- glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells, except in brain. CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O(2) + 2 H(+) = CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H(2)O. COFACTOR: Binds 1 2Fe-2S cluster per subunit (Probable). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5 uM for CMP-NeuAc; PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism. SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum (Probable). TISSUE SPECIFICITY: Expressed in all tissues tested, except in brain. DISRUPTION PHENOTYPE: Mice do not synthesize N-glycolylneuraminic acid (Neu5Gc). SIMILARITY: Belongs to the CMP-Neu5Ac hydroxylase family. SIMILARITY: Contains 1 Rieske domain. SEQUENCE CAUTION: Sequence=BAB91361.1; Type=Erroneous initiation; Sequence=BAB91362.1; Type=Erroneous initiation; Sequence=BAB91553.1; Type=Erroneous initiation;
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR017941 - Rieske_2Fe-2S
Pfam Domains: PF00355 - Rieske [2Fe-2S] domain
ModBase Predicted Comparative 3D Structure on Q61419
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC028474 - Mus musculus cytidine monophospho-N-acetylneuraminic acid hydroxylase, mRNA (cDNA clone IMAGE:4160949). AB061276 - Mus musculus CMAH mRNA for CMP-NeuAc hydroxylase, complete cds, major form of alternative splicing. AB061277 - Mus musculus CMAH mRNA for CMP-NeuAc hydroxylase, complete cds, minor form of alternative splicing. AK166486 - Mus musculus mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930028C23 product:cytidine monophospho-N-acetylneuraminic acid hydroxylase, full insert sequence. BC055079 - Mus musculus cytidine monophospho-N-acetylneuraminic acid hydroxylase, mRNA (cDNA clone MGC:60630 IMAGE:30077348), complete cds. AK145110 - Mus musculus mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830046F18 product:cytidine monophospho-N-acetylneuraminic acid hydroxylase, full insert sequence. D21826 - Mus musculus mRNA for CMP-N-acetylneuraminic acid hydroxylase, complete cds. AK083394 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:C920028L09 product:cytidine monophospho-N-acetylneuraminic acid hydroxylase, full insert sequence. AK145199 - Mus musculus mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930017O18 product:cytidine monophospho-N-acetylneuraminic acid hydroxylase, full insert sequence. AK040274 - Mus musculus 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430082J01 product:CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE homolog [Mus musculus], full insert sequence. DQ705350 - Mus musculus piRNA piR-120672, complete sequence. DQ555036 - Mus musculus piRNA piR-22148, complete sequence. AB351249 - Mus musculus non-coding RNA, oocyte_piRNA2065, complete sequence. AB339564 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA4765, complete sequence. AB337529 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA2730, complete sequence. AB351962 - Mus musculus non-coding RNA, oocyte_piRNA2778, complete sequence. AB352525 - Mus musculus non-coding RNA, oocyte_piRNA3341, complete sequence.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-6144 - CMP- N-glycoloylneuraminate biosynthesis
Other Names for This Gene
Alternate Gene Symbols: CMAH_MOUSE, ENSMUST00000167746.1, ENSMUST00000167746.2, ENSMUST00000167746.3, ENSMUST00000167746.4, ENSMUST00000167746.5, ENSMUST00000167746.6, ENSMUST00000167746.7, NM_001111110, Q61419, Q7TMR9, Q8JZM9, uc011yxl.1, uc011yxl.2, uc011yxl.3, uc011yxl.4 UCSC ID: ENSMUST00000167746.8 RefSeq Accession: NM_001111110
(aka CMAH_MOUSE) Q61419
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.