Mouse Gene Csnk2b (ENSMUST00000174779.7) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt G3UXG7)
RefSeq Summary (NM_001303445): This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gencode Transcript: ENSMUST00000174779.7
Gencode Gene: ENSMUSG00000024387.13
Transcript (Including UTRs)
   Position: mm10 chr17:35,116,198-35,119,775 Size: 3,578 Total Exon Count: 5 Strand: -
Coding Region
   Position: mm10 chr17:35,116,335-35,119,775 Size: 3,441 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:35,116,198-35,119,775)mRNA (may differ from genome)Protein (164 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: G3UXG7_MOUSE
DESCRIPTION: SubName: Full=Casein kinase II subunit beta;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -21.60137-0.158 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016149 - Casein_kin_II_reg-sub_a-hlx
IPR016150 - Casein_kin_II_reg-sub_b-sht
IPR000704 - Casein_kinase_II_reg-sub

Pfam Domains:
PF01214 - Casein kinase II regulatory subunit

SCOP Domains:
52374 - Nucleotidylyl transferase
57798 - Casein kinase II beta subunit

ModBase Predicted Comparative 3D Structure on G3UXG7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019887 protein kinase regulator activity

Biological Process:
GO:0045859 regulation of protein kinase activity

Cellular Component:
GO:0005956 protein kinase CK2 complex


-  Descriptions from all associated GenBank mRNAs
  HE864440 - Mus musculus mRNA for chimera Csnk2b-Ly6g5b splicing isoform 713 (Csnk2b-Ly6g5b gene).
HE864441 - Mus musculus mRNA for chimera Csnk2b-Ly6g5b splicing isoform 979 (Csnk2b-Ly6g5b gene).
HE864442 - Mus musculus mRNA for chimera Csnk2b-Ly6g5b splicing isoform 1108 (Csnk2b-Ly6g5b gene).
X56502 - Mouse CKII beta mRNA for casein kinase II beta subunit.
X52959 - Mouse mRNA for casein kinase II beta subunit (EC 2.7.1.37).
AK161330 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930407M15 product:casein kinase II, beta subunit, full insert sequence.
BC003775 - Mus musculus casein kinase 2, beta polypeptide, mRNA (cDNA clone MGC:5980 IMAGE:3485097), complete cds.
AK010730 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410079O09 product:casein kinase II, beta subunit, full insert sequence.
AK002903 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610042C23 product:casein kinase II, beta subunit, full insert sequence.
AK146186 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730031B05 product:casein kinase II, beta subunit, full insert sequence.
AK012369 - Mus musculus 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2700043N06 product:casein kinase II, beta subunit, full insert sequence.
HE864435 - Mus musculus mRNA for Csnk2b splicing isoform 132 (Csnk2b gene).
HE864436 - Mus musculus mRNA for Csnk2b splicing isoform 670 (Csnk2b gene).
HE864437 - Mus musculus mRNA for Csnk2b splicing isoform 780 (Csnk2b gene).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu03008 - Ribosome biogenesis in eukaryotes
mmu04310 - Wnt signaling pathway
mmu04520 - Adherens junction
mmu04530 - Tight junction
mmu05162 - Measles

-  Other Names for This Gene
  Alternate Gene Symbols: AK161330, G3UXG7, G3UXG7_MOUSE, uc289kkx.1
UCSC ID: uc289kkx.1
RefSeq Accession: NM_001303445
Protein: G3UXG7

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.