Mouse Gene Ptprc (ENSMUST00000183301.7) Description and Page Index
  Description: Mus musculus protein tyrosine phosphatase, receptor type, C (Ptprc), transcript variant 1, mRNA. (from RefSeq NM_001111316)
Gencode Transcript: ENSMUST00000183301.7
Gencode Gene: ENSMUSG00000026395.16
Transcript (Including UTRs)
   Position: mm10 chr1:138,063,413-138,175,267 Size: 111,855 Total Exon Count: 33 Strand: -
Coding Region
   Position: mm10 chr1:138,064,506-138,175,087 Size: 110,582 Coding Exon Count: 32 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:138,063,413-138,175,267)mRNA (may differ from genome)Protein (1293 aa)
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-  Comments and Description Text from UniProtKB
  ID: PTPRC_MOUSE
DESCRIPTION: RecName: Full=Receptor-type tyrosine-protein phosphatase C; EC=3.1.3.48; AltName: Full=Leukocyte common antigen; Short=L-CA; AltName: Full=Lymphocyte antigen 5; Short=Ly-5; AltName: Full=T200; AltName: CD_antigen=CD45; Flags: Precursor;
FUNCTION: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
SUBUNIT: Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes (By similarity). Binds GANAB and PRKCSH.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Membrane raft (By similarity). Note=Colocalized with DPP4 in membrane rafts (By similarity).
DEVELOPMENTAL STAGE: Expression is restricted to the hematopoietic compartment of development.
DOMAIN: The first PTPase domain interacts with SKAP1 (By similarity).
PTM: Heavily N- and O-glycosylated.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
SIMILARITY: Contains 2 fibronectin type-III domains.
SIMILARITY: Contains 2 tyrosine-protein phosphatase domains.
SEQUENCE CAUTION: Sequence=AAA39462.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.4099-0.277 Picture PostScript Text
3' UTR -250.201093-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold
IPR016335 - Leukocyte_common_ag
IPR024739 - PTP_recept_N
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS
IPR000242 - Tyr_Pase_rcpt/non-rcpt

Pfam Domains:
PF00102 - Protein-tyrosine phosphatase
PF12453 - Protein tyrosine phosphatase N terminal
PF12567 - Leukocyte receptor CD45

SCOP Domains:
49265 - Fibronectin type III
52799 - (Phosphotyrosine protein) phosphatases II

ModBase Predicted Comparative 3D Structure on P06800
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0043395 heparan sulfate proteoglycan binding

Biological Process:
GO:0000187 activation of MAPK activity
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002378 immunoglobulin biosynthetic process
GO:0002711 positive regulation of T cell mediated immunity
GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 leukocyte cell-cell adhesion
GO:0010332 response to gamma radiation
GO:0016311 dephosphorylation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0031953 negative regulation of protein autophosphorylation
GO:0034113 heterotypic cell-cell adhesion
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0043410 positive regulation of MAPK cascade
GO:0044770 cell cycle phase transition
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045577 regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048539 bone marrow development
GO:0048864 stem cell development
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:2000473 positive regulation of hematopoietic stem cell migration
GO:2000648 positive regulation of stem cell proliferation
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
GO:0071944 cell periphery


-  Descriptions from all associated GenBank mRNAs
  M14342 - Mus musculus clone R4 lymphocyte differentiation antigen isoform (Ly-5) mRNA, complete cds.
M92933 - Mouse lymphocyte common antigen (Ly5) mRNA, complete cds.
AK154893 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630110L08 product:protein tyrosine phosphatase, receptor type, C, full insert sequence.
BC131655 - Mus musculus cDNA clone IMAGE:40110604.
BC167212 - Synthetic construct Mus musculus clone IMAGE:100068112, MGC:195729 protein tyrosine phosphatase, receptor type, C (Ptprc) mRNA, encodes complete protein.
AK054056 - Mus musculus 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230015G23 product:protein tyrosine phosphatase, receptor type, C, full insert sequence.
BC028512 - Mus musculus protein tyrosine phosphatase, receptor type, C, mRNA (cDNA clone IMAGE:3326806), partial cds.
M11934 - Mouse Ly-5 mRNA.
M17320 - Mus musculus alternatively spliced Ly-5 glycoprotein mRNA, 5' end.
AK171802 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830011N13 product:protein tyrosine phosphatase, receptor type, C, full insert sequence.
AK088215 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430007G18 product:protein tyrosine phosphatase, receptor type, C, full insert sequence.
AK079399 - Mus musculus adult male bone cDNA, RIKEN full-length enriched library, clone:9830107L10 product:protein tyrosine phosphatase, receptor type, C, full insert sequence.
M14343 - Mus musculus clone R2 LDHA pseudogene mRNA, complete sequence.
BC084684 - Mus musculus protein tyrosine phosphatase, receptor type, C, mRNA (cDNA clone IMAGE:30750553), partial cds.
M15174 - Mouse T200 glycoprotein mRNA, 3' region.
EF101553 - Mus musculus lymphocyte common antigen mRNA, partial cds.
L36091 - Mus musculus CD45 antigen.
AK088875 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430029I06 product:unclassifiable, full insert sequence.
AK169451 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630019J11 product:protein tyrosine phosphatase, receptor type, C, full insert sequence.
AK169849 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430038L17 product:unclassifiable, full insert sequence.
AK153775 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630084N11 product:protein tyrosine phosphatase, receptor type, C, full insert sequence.
AK172193 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830103J01 product:protein tyrosine phosphatase, receptor type, C, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04514 - Cell adhesion molecules (CAMs)
mmu04660 - T cell receptor signaling pathway
mmu04666 - Fc gamma R-mediated phagocytosis
mmu05340 - Primary immunodeficiency

BioCarta from NCI Cancer Genome Anatomy Project
m_blymphocytePathway - B Lymphocyte Cell Surface Molecules
m_tcraPathway - Lck and Fyn tyrosine kinases in initiation of TCR Activation
m_tcytotoxicPathway - T Cytotoxic Cell Surface Molecules
m_thelperPathway - T Helper Cell Surface Molecules
m_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

-  Other Names for This Gene
  Alternate Gene Symbols: E9QLT5, Ly-5, NM_001111316, P06800, PTPRC_MOUSE, Q61812, Q61813, Q61814, Q61815, Q78EF1, uc287mej.1
UCSC ID: uc287mej.1
RefSeq Accession: NM_001111316
Protein: P06800 (aka PTPRC_MOUSE)
CCDS: CCDS48383.2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.