ID:PTPRC_MOUSE DESCRIPTION: RecName: Full=Receptor-type tyrosine-protein phosphatase C; EC=188.8.131.52; AltName: Full=Leukocyte common antigen; Short=L-CA; AltName: Full=Lymphocyte antigen 5; Short=Ly-5; AltName: Full=T200; AltName: CD_antigen=CD45; Flags: Precursor; FUNCTION: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes (By similarity). Binds GANAB and PRKCSH. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Membrane raft (By similarity). Note=Colocalized with DPP4 in membrane rafts (By similarity). DEVELOPMENTAL STAGE: Expression is restricted to the hematopoietic compartment of development. DOMAIN: The first PTPase domain interacts with SKAP1 (By similarity). PTM: Heavily N- and O-glycosylated. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. SIMILARITY: Contains 2 fibronectin type-III domains. SIMILARITY: Contains 2 tyrosine-protein phosphatase domains. SEQUENCE CAUTION: Sequence=AAA39462.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00102 - Protein-tyrosine phosphatase PF12453 - Protein tyrosine phosphatase N terminal PF12567 - Leukocyte receptor CD45
SCOP Domains: 49265 - Fibronectin type III 52799 - (Phosphotyrosine protein) phosphatases II
ModBase Predicted Comparative 3D Structure on P06800
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000187 activation of MAPK activity GO:0001915 negative regulation of T cell mediated cytotoxicity GO:0001916 positive regulation of T cell mediated cytotoxicity GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0002244 hematopoietic progenitor cell differentiation GO:0002378 immunoglobulin biosynthetic process GO:0002711 positive regulation of T cell mediated immunity GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0006469 negative regulation of protein kinase activity GO:0006470 protein dephosphorylation GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration GO:0007159 leukocyte cell-cell adhesion GO:0010332 response to gamma radiation GO:0016311 dephosphorylation GO:0030183 B cell differentiation GO:0030217 T cell differentiation GO:0030890 positive regulation of B cell proliferation GO:0031953 negative regulation of protein autophosphorylation GO:0034113 heterotypic cell-cell adhesion GO:0035335 peptidyl-tyrosine dephosphorylation GO:0042098 T cell proliferation GO:0042100 B cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0043410 positive regulation of MAPK cascade GO:0044770 cell cycle phase transition GO:0045059 positive thymic T cell selection GO:0045060 negative thymic T cell selection GO:0045577 regulation of B cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045588 positive regulation of gamma-delta T cell differentiation GO:0046641 positive regulation of alpha-beta T cell proliferation GO:0048304 positive regulation of isotype switching to IgG isotypes GO:0048539 bone marrow development GO:0048864 stem cell development GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation GO:0050852 T cell receptor signaling pathway GO:0050853 B cell receptor signaling pathway GO:0050855 regulation of B cell receptor signaling pathway GO:0050857 positive regulation of antigen receptor-mediated signaling pathway GO:0051209 release of sequestered calcium ion into cytosol GO:0051607 defense response to virus GO:0051726 regulation of cell cycle GO:2000473 positive regulation of hematopoietic stem cell migration GO:2000648 positive regulation of stem cell proliferation GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04514 - Cell adhesion molecules (CAMs) mmu04660 - T cell receptor signaling pathway mmu04666 - Fc gamma R-mediated phagocytosis mmu05340 - Primary immunodeficiency
BioCarta from NCI Cancer Genome Anatomy Project m_blymphocytePathway - B Lymphocyte Cell Surface Molecules m_tcraPathway - Lck and Fyn tyrosine kinases in initiation of TCR Activation m_tcytotoxicPathway - T Cytotoxic Cell Surface Molecules m_thelperPathway - T Helper Cell Surface Molecules m_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor