Human Gene NGFR (ENST00000172229.8) Description and Page Index
Description: Homo sapiens nerve growth factor receptor (NGFR), mRNA. (from RefSeq NM_002507) RefSeq Summary (NM_002507): Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050309.1, M14764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000172229.8/ ENSP00000172229.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000172229.8 Gencode Gene: ENSG00000064300.9 Transcript (Including UTRs) Position: hg38 chr17:49,495,293-49,515,008 Size: 19,716 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr17:49,495,418-49,513,009 Size: 17,592 Coding Exon Count: 6
ID:TNR16_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 16; AltName: Full=Gp80-LNGFR; AltName: Full=Low affinity neurotrophin receptor p75NTR; AltName: Full=Low-affinity nerve growth factor receptor; Short=NGF receptor; AltName: Full=p75 ICD; AltName: CD_antigen=CD271; Flags: Precursor; FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor (By similarity). Interacts with LINGO1. INTERACTION: P05067:APP; NbExp=4; IntAct=EBI-1387782, EBI-77613; P33681:CD80; NbExp=3; IntAct=EBI-1387782, EBI-1031024; P25233:Ndn (xeno); NbExp=3; IntAct=EBI-1387782, EBI-1801080; Q9CPR8:Ndnl2 (xeno); NbExp=3; IntAct=EBI-1387782, EBI-5529102; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. DOMAIN: The extracellular domain is responsible for interaction with NTRK1 (By similarity). PTM: N- and O-glycosylated. PTM: O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08138
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006954 inflammatory response GO:0006955 immune response GO:0007165 signal transduction GO:0007266 Rho protein signal transduction GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007411 axon guidance GO:0010977 negative regulation of neuron projection development GO:0030154 cell differentiation GO:0031293 membrane protein intracellular domain proteolysis GO:0032496 response to lipopolysaccharide GO:0032922 circadian regulation of gene expression GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0042593 glucose homeostasis GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0048011 neurotrophin TRK receptor signaling pathway GO:0048511 rhythmic process GO:0050771 negative regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0051402 neuron apoptotic process GO:0097190 apoptotic signaling pathway GO:1900182 positive regulation of protein localization to nucleus GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1904646 cellular response to beta-amyloid GO:2001273 regulation of glucose import in response to insulin stimulus