Human Gene PAPOLG (ENST00000238714.8) Description and Page Index
Description: Homo sapiens poly(A) polymerase gamma (PAPOLG), mRNA. (from RefSeq NM_022894) RefSeq Summary (NM_022894): This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.233884.1, SRR1803612.281775.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000238714.8/ ENSP00000238714.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000238714.8 Gencode Gene: ENSG00000115421.13 Transcript (Including UTRs) Position: hg38 chr2:60,756,268-60,802,086 Size: 45,819 Total Exon Count: 22 Strand: + Coding Region Position: hg38 chr2:60,756,479-60,797,160 Size: 40,682 Coding Exon Count: 22
ID:PAPOG_HUMAN DESCRIPTION: RecName: Full=Poly(A) polymerase gamma; Short=PAP-gamma; EC=22.214.171.124; AltName: Full=Neo-poly(A) polymerase; Short=Neo-PAP; AltName: Full=Polynucleotide adenylyltransferase gamma; AltName: Full=SRP RNA 3'-adenylating enzyme; FUNCTION: Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. CATALYTIC ACTIVITY: ATP + RNA(n) = diphosphate + RNA(n+1). COFACTOR: Binds 2 magnesium ions. Also active with manganese (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors. SIMILARITY: Belongs to the poly(A) polymerase family. SEQUENCE CAUTION: Sequence=BAB14604.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BWT3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.