Human Gene ZNF415 (ENST00000243643.8) Description and Page Index
  Description: Homo sapiens zinc finger protein 415 (ZNF415), transcript variant 2, mRNA. (from RefSeq NM_018355)
Gencode Transcript: ENST00000243643.8
Gencode Gene: ENSG00000170954.11
Transcript (Including UTRs)
   Position: hg38 chr19:53,107,879-53,132,892 Size: 25,014 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr19:53,108,377-53,122,676 Size: 14,300 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:53,107,879-53,132,892)mRNA (may differ from genome)Protein (555 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedReactome
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN415_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 415;
FUNCTION: Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP- 1 and p53/TP53.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus.
TISSUE SPECIFICITY: Expressed in all tissues examined. Isoforms are differentially expressed. Isoform 3 and isoform 5 were highly expressed, isoform 4 moderately expressed, isoform 2 lower expression, the lowest expression level was seem with isoform 1.
SIMILARITY: Contains 12 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.18 RPKM in Testis
Total median expression: 174.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.70104-0.266 Picture PostScript Text
3' UTR -92.60498-0.186 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q09FC8
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  DQ925695 - Homo sapiens zinc finger protein 415 isoform 1 (ZNF415) mRNA, complete cds.
DQ925698 - Homo sapiens zinc finger protein 415 isoform 4 (ZNF415) mRNA, complete cds.
DQ925696 - Homo sapiens zinc finger protein 415 isoform 2 (ZNF415) mRNA, complete cds.
AY283600 - Homo sapiens zinc finger protein 415 isoform 5 (ZNF415) mRNA, complete cds.
DQ925697 - Homo sapiens zinc finger protein 415 isoform 3 (ZNF415) mRNA, complete cds.
AK095504 - Homo sapiens cDNA FLJ38185 fis, clone FCBBF1000171, highly similar to Homo sapiens zinc finger protein 415 (ZNF415), mRNA.
AF038179 - Homo sapiens clone 23939 mRNA sequence.
BC063880 - Homo sapiens zinc finger protein 415, mRNA (cDNA clone MGC:75472 IMAGE:30388597), complete cds.
AK002053 - Homo sapiens cDNA FLJ11191 fis, clone PLACE1007598, weakly similar to ZINC FINGER PROTEIN 184.
JD468047 - Sequence 449071 from Patent EP1572962.
BC069668 - Homo sapiens zinc finger protein 415, mRNA (cDNA clone MGC:97368 IMAGE:7262632), complete cds.
JD150159 - Sequence 131183 from Patent EP1572962.
JD274490 - Sequence 255514 from Patent EP1572962.
JD434462 - Sequence 415486 from Patent EP1572962.
AB480247 - Homo sapiens Pact mRNA for hypothetical protein, partial cds.
KJ902880 - Synthetic construct Homo sapiens clone ccsbBroadEn_12274 ZNF415 gene, encodes complete protein.
EU446820 - Synthetic construct Homo sapiens clone IMAGE:100070112; IMAGE:100012029; FLH257519.01L zinc finger protein 415 (ZNF415) gene, encodes complete protein.
AB590458 - Synthetic construct DNA, clone: pFN21AE1162, Homo sapiens ZNF415 gene for zinc finger protein 415, without stop codon, in Flexi system.
LF344966 - JP 2014500723-A/152469: Polycomb-Associated Non-Coding RNAs.
MA580543 - JP 2018138019-A/152469: Polycomb-Associated Non-Coding RNAs.
JD047453 - Sequence 28477 from Patent EP1572962.
JD307267 - Sequence 288291 from Patent EP1572962.
JD314818 - Sequence 295842 from Patent EP1572962.
CU686965 - Synthetic construct Homo sapiens gateway clone IMAGE:100022687 5' read ZNF415 mRNA.
JD442228 - Sequence 423252 from Patent EP1572962.
JD204947 - Sequence 185971 from Patent EP1572962.
JD382039 - Sequence 363063 from Patent EP1572962.
JD036821 - Sequence 17845 from Patent EP1572962.
JD328274 - Sequence 309298 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q09FC8 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_018355, Q09FC7, Q09FC8, Q09FC9, Q09FD0, Q6NSZ2, Q6P3S0, Q9NUR2, uc002qaw.1, uc002qaw.2, uc002qaw.3, uc002qaw.4, ZN415_HUMAN
UCSC ID: uc002qaw.4
RefSeq Accession: NM_018355
Protein: Q09FC8 (aka ZN415_HUMAN)
CCDS: CCDS12860.1, CCDS54313.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.