Human Gene RABGAP1L (ENST00000251507.8) from GENCODE V38
  Description: Homo sapiens RAB GTPase activating protein 1 like (RABGAP1L), transcript variant 1, mRNA. (from RefSeq NM_014857)
Gencode Transcript: ENST00000251507.8
Gencode Gene: ENSG00000152061.24
Transcript (Including UTRs)
   Position: hg38 chr1:174,159,517-174,958,182 Size: 798,666 Total Exon Count: 21 Strand: +
Coding Region
   Position: hg38 chr1:174,219,158-174,957,905 Size: 738,748 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:174,159,517-174,958,182)mRNA (may differ from genome)Protein (815 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: RBG1L_HUMAN
DESCRIPTION: RecName: Full=Rab GTPase-activating protein 1-like;
INDUCTION: Up-regulated in esophageal squamous cell carcinomas. Expression is strongly inhibited in the medial septum and hippocampus brain regions of some Alzheimer disease patients.
SIMILARITY: Contains 1 PID domain.
SIMILARITY: Contains 1 Rab-GAP TBC domain.
SEQUENCE CAUTION: Sequence=BAA32316.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.54 RPKM in Heart - Atrial Appendage
Total median expression: 185.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -79.50174-0.457 Picture PostScript Text
3' UTR -53.40277-0.193 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022164 - Kinesin-like
IPR011993 - PH_like_dom
IPR006020 - PTyr_interaction_dom
IPR000195 - Rab-GTPase-TBC_dom

Pfam Domains:
PF12473 - Kinesin protein
PF00640 - Phosphotyrosine interaction domain (PTB/PID)
PF00566 - Rab-GTPase-TBC domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3HZJ
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q5R372
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017137 Rab GTPase binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007049 cell cycle
GO:0015031 protein transport
GO:0031338 regulation of vesicle fusion
GO:0032880 regulation of protein localization
GO:0043547 positive regulation of GTPase activity
GO:0090630 activation of GTPase activity

Cellular Component:
GO:0005634 nucleus
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0031410 cytoplasmic vesicle


-  Descriptions from all associated GenBank mRNAs
  BC041888 - Homo sapiens RAB GTPase activating protein 1-like, mRNA (cDNA clone MGC:44489 IMAGE:5298493), complete cds.
AK095838 - Homo sapiens cDNA FLJ38519 fis, clone HCHON2000751, moderately similar to Rab6 GTPase activating protein.
AL157958 - Novel human mRNA from chromosome 1, clones AL031286, AL022400, AL022171, has similarities to mouse Hh1 mRNA (af118565) and human rab6 GTPase activating protein.
KJ902037 - Synthetic construct Homo sapiens clone ccsbBroadEn_11431 RABGAP1L gene, encodes complete protein.
AB449904 - Homo sapiens TBC1D18 mRNA for TBC1 domain family, member 18, complete cds.
AF279778 - Homo sapiens clone N9 NTera2D1 teratocarcinoma mRNA.
AK074409 - Homo sapiens cDNA FLJ23829 fis, clone HUV01026, highly similar to Rab6 GTPase activating protein.
AY364260 - Homo sapiens clone peg2130 HHL (HHL) mRNA, partial cds.
BC062541 - Homo sapiens RAB GTPase activating protein 1-like, mRNA (cDNA clone IMAGE:5925319), with apparent retained intron.
AB019493 - Homo sapiens IDN4-GGTR9 mRNA, partial cds.
AB019490 - Homo sapiens IDN4-GGTR7 mRNA, partial cds.
AB019489 - Homo sapiens IDN4-GGTR6 mRNA, partial cds.
AB019491 - Homo sapiens IDN4-GGTR8 mRNA, partial cds.
BC018630 - Homo sapiens RAB GTPase activating protein 1-like, mRNA (cDNA clone IMAGE:4308560), partial cds.
AB019492 - Homo sapiens IDN4-GGTR14 mRNA, partial cds.
AB007940 - Homo sapiens KIAA0471 mRNA for KIAA0471 protein.
AB385338 - Synthetic construct DNA, clone: pF1KA0471, Homo sapiens RABGAP1L gene for RAB GTPase activating protein 1-like isoform A, complete cds, without stop codon, in Flexi system.
CR627374 - Homo sapiens mRNA; cDNA DKFZp686E1450 (from clone DKFZp686E1450).
AL035303 - H.sapiens gene from PAC 102G20.
CU692044 - Synthetic construct Homo sapiens gateway clone IMAGE:100020966 5' read RABGAP1L mRNA.
KT900847 - Homo sapiens clone AS6-1_AT1 L1-chimeric transcript sequence.
KT900848 - Homo sapiens clone AS6-3 L1-chimeric transcript sequence.
AL049701 - Human gene from PAC 433G19, chromosome 1.
BC012094 - Homo sapiens RAB GTPase activating protein 1-like, mRNA (cDNA clone IMAGE:4661946), complete cds.
AL049702 - Human gene from PAC 433G19, chromosome 1.
KJ906012 - Synthetic construct Homo sapiens clone ccsbBroadEn_15682 RABGAP1L gene, encodes complete protein.
JF432441 - Synthetic construct Homo sapiens clone IMAGE:100073649 RAB GTPase activating protein 1-like (RABGAP1L) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000251507.1, ENST00000251507.2, ENST00000251507.3, ENST00000251507.4, ENST00000251507.5, ENST00000251507.6, ENST00000251507.7, HHL, KIAA0471, NM_014857, O75059, Q3ZTR8, Q5R369, Q5R372, Q8IVV0, Q8N921, Q8WV78, Q9NSP8, Q9UQ19, Q9UQP5, Q9Y6Y5, Q9Y6Y6, RBG1L_HUMAN, uc001gjx.1, uc001gjx.2, uc001gjx.3, uc001gjx.4
UCSC ID: ENST00000251507.8
RefSeq Accession: NM_014857
Protein: Q5R372 (aka RBG1L_HUMAN)
CCDS: CCDS1314.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.