Human Gene CHD5 (ENST00000262450.8) from GENCODE V44
Description: Homo sapiens chromodomain helicase DNA binding protein 5 (CHD5), mRNA. (from RefSeq NM_015557) RefSeq Summary (NM_015557): This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000262450.8 Gencode Gene: ENSG00000116254.18 Transcript (Including UTRs) Position: hg38 chr1:6,101,787-6,180,321 Size: 78,535 Total Exon Count: 42 Strand: - Coding Region Position: hg38 chr1:6,106,280-6,180,023 Size: 73,744 Coding Exon Count: 41
ID:CHD5_HUMAN DESCRIPTION: RecName: Full=Chromodomain-helicase-DNA-binding protein 5; Short=CHD-5; EC=3.6.4.12; AltName: Full=ATP-dependent helicase CHD5; FUNCTION: May play a role in the development of the nervous system and the pathogenesis of neural tumors. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland. SIMILARITY: Belongs to the SNF2/RAD54 helicase family. SIMILARITY: Contains 2 chromo domains. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SIMILARITY: Contains 2 PHD-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08074 - CHDCT2 (NUC038) domain PF08073 - CHDNT (NUC034) domain PF00385 - Chromo (CHRromatin Organisation MOdifier) domain PF06461 - Domain of Unknown Function (DUF1086) PF06465 - Domain of Unknown Function (DUF1087) PF00271 - Helicase conserved C-terminal domain PF00628 - PHD-finger PF00176 - SNF2 family N-terminal domain
ModBase Predicted Comparative 3D Structure on Q8TDI0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
