Human Gene IL1B (ENST00000263341.7) Description and Page Index
Description: Homo sapiens interleukin 1 beta (IL1B), mRNA. (from RefSeq NM_000576) RefSeq Summary (NM_000576): The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.109183.1, SRR5189652.136888.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000263341.7 Gencode Gene: ENSG00000125538.12 Transcript (Including UTRs) Position: hg38 chr2:112,829,751-112,836,779 Size: 7,029 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr2:112,830,361-112,836,229 Size: 5,869 Coding Exon Count: 6
ID:IL1B_HUMAN DESCRIPTION: RecName: Full=Interleukin-1 beta; Short=IL-1 beta; AltName: Full=Catabolin; Flags: Precursor; FUNCTION: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. DOMAIN: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. SIMILARITY: Belongs to the IL-1 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/IL1BID40950ch2q13.html"; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1b/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01584
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0000187 activation of MAPK activity GO:0001660 fever generation GO:0001934 positive regulation of protein phosphorylation GO:0002711 positive regulation of T cell mediated immunity GO:0006915 apoptotic process GO:0006954 inflammatory response GO:0006955 immune response GO:0007165 signal transduction GO:0007267 cell-cell signaling GO:0007566 embryo implantation GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0009743 response to carbohydrate GO:0010469 regulation of receptor activity GO:0010575 positive regulation of vascular endothelial growth factor production GO:0010628 positive regulation of gene expression GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010829 negative regulation of glucose transport GO:0014805 smooth muscle adaptation GO:0019221 cytokine-mediated signaling pathway GO:0030213 hyaluronan biosynthetic process GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030730 sequestering of triglyceride GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0031622 positive regulation of fever generation GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032308 positive regulation of prostaglandin secretion GO:0032496 response to lipopolysaccharide GO:0032611 interleukin-1 beta production GO:0032635 interleukin-6 production GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032729 positive regulation of interferon-gamma production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0033129 positive regulation of histone phosphorylation GO:0033198 response to ATP GO:0034116 positive regulation of heterotypic cell-cell adhesion GO:0035066 positive regulation of histone acetylation GO:0035234 ectopic germ cell programmed cell death GO:0035505 positive regulation of myosin light chain kinase activity GO:0035690 cellular response to drug GO:0042102 positive regulation of T cell proliferation GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043407 negative regulation of MAP kinase activity GO:0043491 protein kinase B signaling GO:0045080 positive regulation of chemokine biosynthetic process GO:0045086 positive regulation of interleukin-2 biosynthetic process GO:0045410 positive regulation of interleukin-6 biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045766 positive regulation of angiogenesis GO:0045833 negative regulation of lipid metabolic process GO:0045840 positive regulation of mitotic nuclear division GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046330 positive regulation of JNK cascade GO:0046627 negative regulation of insulin receptor signaling pathway GO:0046827 positive regulation of protein export from nucleus GO:0050691 regulation of defense response to virus by host GO:0050766 positive regulation of phagocytosis GO:0050796 regulation of insulin secretion GO:0050805 negative regulation of synaptic transmission GO:0050900 leukocyte migration GO:0050995 negative regulation of lipid catabolic process GO:0050996 positive regulation of lipid catabolic process GO:0050999 regulation of nitric-oxide synthase activity GO:0051044 positive regulation of membrane protein ectodomain proteolysis GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051781 positive regulation of cell division GO:0060355 positive regulation of cell adhesion molecule production GO:0060559 positive regulation of calcidiol 1-monooxygenase activity GO:0070164 negative regulation of adiponectin secretion GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070487 monocyte aggregation GO:0070498 interleukin-1-mediated signaling pathway GO:0071260 cellular response to mechanical stimulus GO:0071310 cellular response to organic substance GO:0071407 cellular response to organic cyclic compound GO:0071639 positive regulation of monocyte chemotactic protein-1 production GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:1900745 positive regulation of p38MAPK cascade GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1903140 regulation of establishment of endothelial barrier GO:2000778 positive regulation of interleukin-6 secretion GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand