Human Gene PRDM15 (ENST00000269844.4) Description and Page Index
  Description: Homo sapiens PR/SET domain 15 (PRDM15), transcript variant 1, mRNA. (from RefSeq NM_022115)
Gencode Transcript: ENST00000269844.4
Gencode Gene: ENSG00000141956.13
Transcript (Including UTRs)
   Position: hg38 chr21:41,800,994-41,879,482 Size: 78,489 Total Exon Count: 31 Strand: -
Coding Region
   Position: hg38 chr21:41,801,240-41,879,371 Size: 78,132 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:41,800,994-41,879,482)mRNA (may differ from genome)Protein (1507 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PRD15_HUMAN
DESCRIPTION: RecName: Full=PR domain zinc finger protein 15; AltName: Full=PR domain-containing protein 15; AltName: Full=Zinc finger protein 298;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 16 C2H2-type zinc fingers.
SIMILARITY: Contains 1 SET domain.
SEQUENCE CAUTION: Sequence=AAL60596.1; Type=Erroneous initiation; Sequence=AAM53515.1; Type=Erroneous translation; Note=Erroneous CDS prediction; Sequence=AAM53516.1; Type=Erroneous translation; Note=Erroneous CDS prediction; Sequence=BAA95527.1; Type=Erroneous gene model prediction;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.63 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 91.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.20111-0.326 Picture PostScript Text
3' UTR -76.80246-0.312 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001214 - SET_dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

ModBase Predicted Comparative 3D Structure on P57071
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0032259 methylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016604 nuclear body


-  Descriptions from all associated GenBank mRNAs
  AY063456 - Homo sapiens C21orf83 isoform C (C21orf83) mRNA, complete cds.
BC067102 - Homo sapiens PR domain containing 15, mRNA (cDNA clone MGC:71480 IMAGE:5925140), complete cds.
AB051812 - Homo sapiens mRNA for zinc finger protein ZNF298a, complete cds.
AB051813 - Homo sapiens mRNA for zinc finger protein ZNF298b, complete cds.
AB051814 - Homo sapiens mRNA for zinc finger protein ZNF298c, complete cds.
AB051815 - Homo sapiens mRNA for zinc finger protein ZNF298d, complete cds.
AY078498 - Homo sapiens zinc finger 298 mRNA, complete cds.
KJ903045 - Synthetic construct Homo sapiens clone ccsbBroadEn_12439 PRDM15 gene, encodes complete protein.
AB209162 - Homo sapiens mRNA for PR domain containing 15 variant protein.
BC032305 - Homo sapiens cDNA clone IMAGE:5181414, **** WARNING: chimeric clone ****.
AL109788 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 814590.
AF426259 - Homo sapiens putative C21orf83B protein form A (C21orf83) mRNA, complete cds.
AF426260 - Homo sapiens putative C21orf83B protein form B (C21orf83) mRNA, complete cds.
JD085990 - Sequence 67014 from Patent EP1572962.
JD235309 - Sequence 216333 from Patent EP1572962.
JD060581 - Sequence 41605 from Patent EP1572962.
JD475527 - Sequence 456551 from Patent EP1572962.
AF276513 - Homo sapiens PR-domain zinc finger protein 15 (PRDM15) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: C21orf83, NM_022115, P57071, PRD15_HUMAN, Q8N0X3, Q8NEX0, Q9NQV3, uc002yzq.1, ZNF298
UCSC ID: uc002yzq.1
RefSeq Accession: NM_022115
Protein: P57071 (aka PRD15_HUMAN or PRDF_HUMAN)
CCDS: CCDS13676.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.