Human Gene PRDM15 (ENST00000269844.4) Description and Page Index
Description: Homo sapiens PR/SET domain 15 (PRDM15), transcript variant 1, mRNA. (from RefSeq NM_022115)
Gencode Transcript: ENST00000269844.4
Gencode Gene: ENSG00000141956.13
Transcript (Including UTRs)
Position: hg38 chr21:41,800,994-41,879,482 Size: 78,489 Total Exon Count: 31 Strand: -
Position: hg38 chr21:41,801,240-41,879,371 Size: 78,132 Coding Exon Count: 31
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=PR domain zinc finger protein 15; AltName: Full=PR domain-containing protein 15; AltName: Full=Zinc finger protein 298;
FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Contains 16 C2H2-type zinc fingers. SIMILARITY: Contains 1 SET domain. SEQUENCE CAUTION: Sequence=AAL60596.1; Type=Erroneous initiation; Sequence=AAM53515.1; Type=Erroneous translation; Note=Erroneous CDS prediction; Sequence=AAM53516.1; Type=Erroneous translation; Note=Erroneous CDS prediction; Sequence=BAA95527.1; Type=Erroneous gene model prediction;
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001214 - SET_dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
Pfam Domains: PF00096 - Zinc finger, C2H2 type
ModBase Predicted Comparative 3D Structure on P57071
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AY063456 - Homo sapiens C21orf83 isoform C (C21orf83) mRNA, complete cds. BC067102 - Homo sapiens PR domain containing 15, mRNA (cDNA clone MGC:71480 IMAGE:5925140), complete cds. AB051812 - Homo sapiens mRNA for zinc finger protein ZNF298a, complete cds. AB051813 - Homo sapiens mRNA for zinc finger protein ZNF298b, complete cds. AB051814 - Homo sapiens mRNA for zinc finger protein ZNF298c, complete cds. AB051815 - Homo sapiens mRNA for zinc finger protein ZNF298d, complete cds. AY078498 - Homo sapiens zinc finger 298 mRNA, complete cds. KJ903045 - Synthetic construct Homo sapiens clone ccsbBroadEn_12439 PRDM15 gene, encodes complete protein. AB209162 - Homo sapiens mRNA for PR domain containing 15 variant protein. BC032305 - Homo sapiens cDNA clone IMAGE:5181414, **** WARNING: chimeric clone ****. AL109788 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 814590. AF426259 - Homo sapiens putative C21orf83B protein form A (C21orf83) mRNA, complete cds. AF426260 - Homo sapiens putative C21orf83B protein form B (C21orf83) mRNA, complete cds. JD085990 - Sequence 67014 from Patent EP1572962. JD235309 - Sequence 216333 from Patent EP1572962. JD060581 - Sequence 41605 from Patent EP1572962. JD475527 - Sequence 456551 from Patent EP1572962. AF276513 - Homo sapiens PR-domain zinc finger protein 15 (PRDM15) mRNA, partial cds.
Other Names for This Gene
Alternate Gene Symbols: C21orf83, NM_022115, P57071, PRD15_HUMAN, Q8N0X3, Q8NEX0, Q9NQV3, uc002yzq.1, ZNF298 UCSC ID: uc002yzq.1 RefSeq Accession: NM_022115
(aka PRD15_HUMAN or PRDF_HUMAN) P57071
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.