Human Gene PPP1R1C (ENST00000280295.7) Description and Page Index
  Description: Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA. (from RefSeq NM_001261424)
RefSeq Summary (NM_001261424): Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010].
Gencode Transcript: ENST00000280295.7
Gencode Gene: ENSG00000150722.10
Transcript (Including UTRs)
   Position: hg38 chr2:181,985,877-182,130,018 Size: 144,142 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr2:181,986,111-182,117,295 Size: 131,185 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:181,985,877-182,130,018)mRNA (may differ from genome)Protein (116 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 1C; AltName: Full=Inhibitor-5 of protein phosphatase 1; Short=IPP5;
FUNCTION: Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis.
SUBUNIT: Interacts with PPP1CB.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, liver and testis (at protein level).
PTM: Phosphorylation of Thr-34 is required for activity.
SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.38 RPKM in Testis
Total median expression: 18.41 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.20234-0.279 Picture PostScript Text
3' UTR -192.001051-0.183 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008466 - PPI_1DARPP-32

Pfam Domains:
PF05395 - Protein phosphatase inhibitor 1/DARPP-32

ModBase Predicted Comparative 3D Structure on Q8WVI7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004864 protein phosphatase inhibitor activity
GO:0004865 protein serine/threonine phosphatase inhibitor activity

Biological Process:
GO:0006469 negative regulation of protein kinase activity
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0035556 intracellular signal transduction
GO:0051301 cell division

Cellular Component:
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  AK311571 - Homo sapiens cDNA, FLJ18613.
AK129898 - Homo sapiens cDNA FLJ26388 fis, clone HRT07241.
AF494535 - Homo sapiens protein phosphatase 1 regulatory subunit 1A mRNA, complete cds.
BX647581 - Homo sapiens mRNA; cDNA DKFZp313E0333 (from clone DKFZp313E0333).
BC017943 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 1C, mRNA (cDNA clone MGC:24041 IMAGE:4288919), complete cds.
KJ905628 - Synthetic construct Homo sapiens clone ccsbBroadEn_15267 PPP1R1C-like gene, encodes complete protein.
JD099292 - Sequence 80316 from Patent EP1572962.
JD037019 - Sequence 18043 from Patent EP1572962.
AK311322 - Homo sapiens cDNA, FLJ18364.
JD240929 - Sequence 221953 from Patent EP1572962.
JD085768 - Sequence 66792 from Patent EP1572962.
JD292934 - Sequence 273958 from Patent EP1572962.
JD358496 - Sequence 339520 from Patent EP1572962.
JD469501 - Sequence 450525 from Patent EP1572962.
JD260343 - Sequence 241367 from Patent EP1572962.
JD057493 - Sequence 38517 from Patent EP1572962.
JD306516 - Sequence 287540 from Patent EP1572962.
JD245708 - Sequence 226732 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001261424, PPR1C_HUMAN, Q5HYJ5, Q8TD54, Q8WVI7, uc010frm.1, uc010frm.2, uc010frm.3
UCSC ID: uc010frm.3
RefSeq Accession: NM_001261424
Protein: Q8WVI7 (aka PPR1C_HUMAN)
CCDS: CCDS58740.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.