Human Gene PPP1R1C (ENST00000280295.7) Description and Page Index
  Description: Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA. (from RefSeq NM_001261424)
RefSeq Summary (NM_001261424): Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010].
Gencode Transcript: ENST00000280295.7
Gencode Gene: ENSG00000150722.10
Transcript (Including UTRs)
   Position: hg38 chr2:181,985,877-182,130,018 Size: 144,142 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr2:181,986,111-182,117,295 Size: 131,185 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:181,985,877-182,130,018)mRNA (may differ from genome)Protein (116 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtOMIMPubMedStanford SOURCE
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: PPR1C_HUMAN
DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 1C; AltName: Full=Inhibitor-5 of protein phosphatase 1; Short=IPP5;
FUNCTION: Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis.
SUBUNIT: Interacts with PPP1CB.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, liver and testis (at protein level).
PTM: Phosphorylation of Thr-34 is required for activity.
SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.38 RPKM in Testis
Total median expression: 18.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.20234-0.279 Picture PostScript Text
3' UTR -192.001051-0.183 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008466 - PPI_1DARPP-32

Pfam Domains:
PF05395 - Protein phosphatase inhibitor 1/DARPP-32

ModBase Predicted Comparative 3D Structure on Q8WVI7
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004864 protein phosphatase inhibitor activity
GO:0004865 protein serine/threonine phosphatase inhibitor activity

Biological Process:
GO:0006469 negative regulation of protein kinase activity
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0035556 intracellular signal transduction
GO:0051301 cell division

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK311571 - Homo sapiens cDNA, FLJ18613.
AK129898 - Homo sapiens cDNA FLJ26388 fis, clone HRT07241.
AF494535 - Homo sapiens protein phosphatase 1 regulatory subunit 1A mRNA, complete cds.
BX647581 - Homo sapiens mRNA; cDNA DKFZp313E0333 (from clone DKFZp313E0333).
BC017943 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 1C, mRNA (cDNA clone MGC:24041 IMAGE:4288919), complete cds.
KJ905628 - Synthetic construct Homo sapiens clone ccsbBroadEn_15267 PPP1R1C-like gene, encodes complete protein.
JD099292 - Sequence 80316 from Patent EP1572962.
JD037019 - Sequence 18043 from Patent EP1572962.
AK311322 - Homo sapiens cDNA, FLJ18364.
JD240929 - Sequence 221953 from Patent EP1572962.
JD085768 - Sequence 66792 from Patent EP1572962.
JD292934 - Sequence 273958 from Patent EP1572962.
JD358496 - Sequence 339520 from Patent EP1572962.
JD469501 - Sequence 450525 from Patent EP1572962.
JD260343 - Sequence 241367 from Patent EP1572962.
JD057493 - Sequence 38517 from Patent EP1572962.
JD306516 - Sequence 287540 from Patent EP1572962.
JD245708 - Sequence 226732 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001261424, PPR1C_HUMAN, Q5HYJ5, Q8TD54, Q8WVI7, uc010frm.1, uc010frm.2, uc010frm.3
UCSC ID: uc010frm.3
RefSeq Accession: NM_001261424
Protein: Q8WVI7 (aka PPR1C_HUMAN)
CCDS: CCDS58740.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.