Human Gene PPP1R1C (ENST00000280295.7) Description and Page Index
Description: Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA. (from RefSeq NM_001261424) RefSeq Summary (NM_001261424): Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]. Gencode Transcript: ENST00000280295.7 Gencode Gene: ENSG00000150722.10 Transcript (Including UTRs) Position: hg38 chr2:181,985,877-182,130,018 Size: 144,142 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr2:181,986,111-182,117,295 Size: 131,185 Coding Exon Count: 5
ID:PPR1C_HUMAN DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 1C; AltName: Full=Inhibitor-5 of protein phosphatase 1; Short=IPP5; FUNCTION: Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis. SUBUNIT: Interacts with PPP1CB. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, liver and testis (at protein level). PTM: Phosphorylation of Thr-34 is required for activity. SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05395 - Protein phosphatase inhibitor 1/DARPP-32
ModBase Predicted Comparative 3D Structure on Q8WVI7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.