Human Gene DNAJC11 (ENST00000294401.11) from GENCODE V44
  Description: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NVH1-1; Sequence=Displayed; Name=2; IsoId=Q9NVH1-2; Sequence=VSP_019933; Name=3; IsoId=Q9NVH1-3; Sequence=VSP_019932; (from UniProt Q9NVH1)
Gencode Transcript: ENST00000294401.11
Gencode Gene: ENSG00000007923.17
Transcript (Including UTRs)
   Position: hg38 chr1:6,635,113-6,701,924 Size: 66,812 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg38 chr1:6,635,675-6,701,800 Size: 66,126 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:6,635,113-6,701,924)mRNA (may differ from genome)Protein (507 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedReactome
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DJC11_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 11;
SIMILARITY: Belongs to the DNAJC11 family.
SIMILARITY: Contains 1 J domain.
SEQUENCE CAUTION: Sequence=AAH08772.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.97 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 406.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.60124-0.489 Picture PostScript Text
3' UTR -195.10562-0.347 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024586 - DnaJ-like_C11_C
IPR001623 - DnaJ_N
IPR018253 - Heat_shock_DnaJ_CS
IPR003095 - Hsp_DnaJ

Pfam Domains:
PF00226 - DnaJ domain
PF11875 - Domain of unknown function (DUF3395)

ModBase Predicted Comparative 3D Structure on Q9NVH1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0042407 cristae formation

Cellular Component:
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0001401 mitochondrial sorting and assembly machinery complex
GO:0061617 MICOS complex


-  Descriptions from all associated GenBank mRNAs
  AF306695 - Homo sapiens clone R5' mRNA sequence.
AL833841 - Homo sapiens mRNA; cDNA DKFZp727C181 (from clone DKFZp727C181).
BC008772 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone IMAGE:3139659), partial cds.
BC006086 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone MGC:12593 IMAGE:3946414), complete cds.
AK001599 - Homo sapiens cDNA FLJ10737 fis, clone NT2RP3001426, weakly similar to DNAJ PROTEIN.
BC014145 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone MGC:20641 IMAGE:4762069), complete cds.
AY336749 - Homo sapiens DNAJ domain-containing protein mRNA, complete cds.
AK294539 - Homo sapiens cDNA FLJ53979 complete cds, highly similar to DnaJ homolog subfamily C member 11.
HQ447595 - Synthetic construct Homo sapiens clone IMAGE:100070938; CCSB014704_02 DnaJ (Hsp40) homolog, subfamily C, member 11 (DNAJC11) gene, encodes complete protein.
KJ899180 - Synthetic construct Homo sapiens clone ccsbBroadEn_08574 DNAJC11 gene, encodes complete protein.
KJ902869 - Synthetic construct Homo sapiens clone ccsbBroadEn_12263 DNAJC11 gene, encodes complete protein.
AF306694 - Homo sapiens clone 305-9E mRNA sequence.
CU675235 - Synthetic construct Homo sapiens gateway clone IMAGE:100023074 5' read DNAJC11 mRNA.
CU680804 - Synthetic construct Homo sapiens gateway clone IMAGE:100019720 5' read DNAJC11 mRNA.
AK025491 - Homo sapiens cDNA: FLJ21838 fis, clone HEP01752, highly similar to AF052158 Homo sapiens clone 24616 mRNA sequence.
AL109978 - Novel human gene mapping to chomosome 1.
AF052158 - Homo sapiens clone 24616 mRNA sequence.
AK093709 - Homo sapiens cDNA FLJ36390 fis, clone THYMU2008990.
AX748271 - Sequence 1796 from Patent EP1308459.
AK095386 - Homo sapiens cDNA FLJ38067 fis, clone CTONG2015345, highly similar to DnaJ homolog subfamily C member 11.
JD439026 - Sequence 420050 from Patent EP1572962.
JD419674 - Sequence 400698 from Patent EP1572962.
JD030749 - Sequence 11773 from Patent EP1572962.
JD020437 - Sequence 1461 from Patent EP1572962.
JD126012 - Sequence 107036 from Patent EP1572962.
JD068633 - Sequence 49657 from Patent EP1572962.
JD470836 - Sequence 451860 from Patent EP1572962.
JD373085 - Sequence 354109 from Patent EP1572962.
JD126681 - Sequence 107705 from Patent EP1572962.
JD364191 - Sequence 345215 from Patent EP1572962.
JD223617 - Sequence 204641 from Patent EP1572962.
JD446829 - Sequence 427853 from Patent EP1572962.
JD406045 - Sequence 387069 from Patent EP1572962.
AK298378 - Homo sapiens cDNA FLJ59729 complete cds, highly similar to DnaJ homolog subfamily C member 11.
JD400628 - Sequence 381652 from Patent EP1572962.
JD382362 - Sequence 363386 from Patent EP1572962.
JD160047 - Sequence 141071 from Patent EP1572962.
JD186105 - Sequence 167129 from Patent EP1572962.
JD317139 - Sequence 298163 from Patent EP1572962.
AF306696 - Homo sapiens clone R6r/1-6H mRNA sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NVH1 (Reactome details) participates in the following event(s):

R-HSA-8949613 Cristae formation
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: AF306695, DJC11_HUMAN, ENST00000294401.1, ENST00000294401.10, ENST00000294401.2, ENST00000294401.3, ENST00000294401.4, ENST00000294401.5, ENST00000294401.6, ENST00000294401.7, ENST00000294401.8, ENST00000294401.9, Q4VWF5, Q5VZN0, Q6PK20, Q6PK70, Q8NDM2, Q96CL7, Q9NVH1, uc001aog.1, uc001aog.2, uc001aog.3
UCSC ID: ENST00000294401.11
RefSeq Accession: NM_018198
Protein: Q9NVH1 (aka DJC11_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.