Human Gene YY1AP1 (ENST00000295566.8) Description and Page Index
  Description: Homo sapiens YY1 associated protein 1 (YY1AP1), transcript variant 2, mRNA. (from RefSeq NM_139118)
RefSeq Summary (NM_139118): The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000295566.8
Gencode Gene: ENSG00000163374.19
Transcript (Including UTRs)
   Position: hg38 chr1:155,659,446-155,689,000 Size: 29,555 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr1:155,659,657-155,688,976 Size: 29,320 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:155,659,446-155,689,000)mRNA (may differ from genome)Protein (796 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGImyGene2neXtProtOMIM
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: YYAP1_HUMAN
DESCRIPTION: RecName: Full=YY1-associated protein 1; AltName: Full=Hepatocellular carcinoma susceptibility protein; AltName: Full=Hepatocellular carcinoma-associated protein 2;
FUNCTION: Enhances transcription activation by YY1. May play a role in cell cycle regulation.
SUBUNIT: Interacts with YY1. Interacts with MAD2L2.
INTERACTION: P54253:ATXN1; NbExp=4; IntAct=EBI-946122, EBI-930964;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas.
SEQUENCE CAUTION: Sequence=BAA91871.1; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: YY1AP1
Diseases sorted by gene-association score: grange syndrome* (1278), fibromuscular dysplasia (5), hepatocellular carcinoma (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.77 RPKM in Testis
Total median expression: 1321.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.6024-0.067 Picture PostScript Text
3' UTR -64.20211-0.304 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9H869
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008283 cell proliferation
GO:0030154 cell differentiation
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0031011 Ino80 complex


-  Descriptions from all associated GenBank mRNAs
  BC009358 - Homo sapiens YY1 associated protein 1, mRNA (cDNA clone IMAGE:4301193), partial cds.
BC014906 - Homo sapiens YY1 associated protein 1, mRNA (cDNA clone MGC:16986 IMAGE:3922542), complete cds.
JD467923 - Sequence 448947 from Patent EP1572962.
AK225883 - Homo sapiens mRNA for YY1-associated protein isoform 1 variant, clone: FCC123A09.
BC025272 - Homo sapiens YY1 associated protein 1, mRNA (cDNA clone IMAGE:4551418), with apparent retained intron.
AF206328 - Homo sapiens hepatocellular carcinoma susceptibility protein (HCCA2) mRNA, complete cds.
AF466401 - Homo sapiens YY1 associated protein mRNA, complete cds.
CR749789 - Homo sapiens mRNA; cDNA DKFZp686J14104 (from clone DKFZp686J14104).
BC003500 - Homo sapiens YY1 associated protein 1, mRNA (cDNA clone IMAGE:3029183).
AY604179 - Homo sapiens YY1-associated protein transcript variant 6 (YY1AP) mRNA, complete cds.
AK125590 - Homo sapiens cDNA FLJ43602 fis, clone SPLEN2003297.
AK297562 - Homo sapiens cDNA FLJ60306 complete cds, highly similar to YY1-associated protein 1.
AK023976 - Homo sapiens cDNA FLJ13914 fis, clone Y79AA1000313.
AF203474 - Homo sapiens hepatocellular carcinoma-associated protein (HCCA1) mRNA, complete cds.
AK303944 - Homo sapiens cDNA FLJ56201 complete cds, highly similar to YY1-associated protein 1.
BC001655 - Homo sapiens YY1 associated protein 1, mRNA (cDNA clone MGC:2813 IMAGE:2961648), complete cds.
BC001843 - Homo sapiens YY1 associated protein 1, mRNA (cDNA clone MGC:4481 IMAGE:2961648), complete cds.
BC044887 - Homo sapiens YY1 associated protein 1, mRNA (cDNA clone MGC:51239 IMAGE:5276742), complete cds.
AK001737 - Homo sapiens cDNA FLJ10875 fis, clone NT2RP4001828.
BC008766 - Homo sapiens YY1 associated protein 1, mRNA (cDNA clone MGC:926 IMAGE:3051391), complete cds.
JD060757 - Sequence 41781 from Patent EP1572962.
JD080412 - Sequence 61436 from Patent EP1572962.
JD241569 - Sequence 222593 from Patent EP1572962.
AK303386 - Homo sapiens cDNA FLJ56189 complete cds, highly similar to YY1-associated protein 1.
AK315049 - Homo sapiens cDNA, FLJ95997.
KJ902797 - Synthetic construct Homo sapiens clone ccsbBroadEn_12191 YY1AP1 gene, encodes complete protein.
KJ899103 - Synthetic construct Homo sapiens clone ccsbBroadEn_08497 YY1AP1 gene, encodes complete protein.
KJ894168 - Synthetic construct Homo sapiens clone ccsbBroadEn_03562 YY1AP1 gene, encodes complete protein.
KJ906220 - Synthetic construct Homo sapiens clone ccsbBroadEn_15890 YY1AP1 gene, encodes complete protein.
AM393344 - Synthetic construct Homo sapiens clone IMAGE:100002481 for hypothetical protein (YY1AP1 gene).
AM393852 - Synthetic construct Homo sapiens clone IMAGE:100002492 for hypothetical protein (YY1AP1 gene).
AK298904 - Homo sapiens cDNA FLJ59281 complete cds, highly similar to YY1-associated protein 1.
CU674814 - Synthetic construct Homo sapiens gateway clone IMAGE:100017794 5' read YY1AP1 mRNA.
AK309701 - Homo sapiens cDNA, FLJ99742.
JD174520 - Sequence 155544 from Patent EP1572962.
AK303046 - Homo sapiens cDNA FLJ59159 complete cds, highly similar to YY1-associated protein 1.
CU677111 - Synthetic construct Homo sapiens gateway clone IMAGE:100021261 5' read YY1AP1 mRNA.
JD436211 - Sequence 417235 from Patent EP1572962.
JD167438 - Sequence 148462 from Patent EP1572962.
JD428849 - Sequence 409873 from Patent EP1572962.
JD556754 - Sequence 537778 from Patent EP1572962.
JD429941 - Sequence 410965 from Patent EP1572962.
JD360986 - Sequence 342010 from Patent EP1572962.
JD073621 - Sequence 54645 from Patent EP1572962.
JD039664 - Sequence 20688 from Patent EP1572962.
JD088149 - Sequence 69173 from Patent EP1572962.
JD088148 - Sequence 69172 from Patent EP1572962.
JD153941 - Sequence 134965 from Patent EP1572962.
JD401217 - Sequence 382241 from Patent EP1572962.
JD447969 - Sequence 428993 from Patent EP1572962.
JD460391 - Sequence 441415 from Patent EP1572962.
JD080029 - Sequence 61053 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B0QZ54, B4E0I0, D3DV96, D3DV98, HCCA2, NM_139118, Q5VYZ4, Q5VYZ7, Q7L4C3, Q7L5E2, Q8IXA6, Q8TEW5, Q8TF04, Q96HB6, Q9BQ64, Q9H869, Q9NV84, uc001fln.1, uc001fln.2, uc001fln.3, uc001fln.4, YY1AP, YYAP1_HUMAN
UCSC ID: uc001fln.4
RefSeq Accession: NM_139118
Protein: Q9H869 (aka YYAP1_HUMAN)
CCDS: CCDS1115.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.