Human Gene RRAD (ENST00000299759.11) Description and Page Index
  Description: Homo sapiens RRAD, Ras related glycolysis inhibitor and calcium channel regulator (RRAD), transcript variant 2, mRNA. (from RefSeq NM_004165)
Gencode Transcript: ENST00000299759.11
Gencode Gene: ENSG00000166592.12
Transcript (Including UTRs)
   Position: hg38 chr16:66,921,685-66,925,535 Size: 3,851 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr16:66,922,076-66,925,179 Size: 3,104 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:66,921,685-66,925,535)mRNA (may differ from genome)Protein (308 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: RAD_HUMAN
DESCRIPTION: RecName: Full=GTP-binding protein RAD; AltName: Full=RAD1; AltName: Full=Ras associated with diabetes;
FUNCTION: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
SUBUNIT: Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).
INTERACTION: O95273:CCNDBP1; NbExp=5; IntAct=EBI-3911502, EBI-748961;
SUBCELLULAR LOCATION: Cell membrane (By similarity).
TISSUE SPECIFICITY: Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
INDUCTION: Down-regulated in failing hearts.
SIMILARITY: Belongs to the small GTPase superfamily. RGK family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 158.68 RPKM in Muscle - Skeletal
Total median expression: 924.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.30142-0.375 Picture PostScript Text
3' UTR -170.70391-0.437 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR017358 - Small_GTPase_GEM/REM/Rad
IPR020849 - Small_GTPase_Ras

Pfam Domains:
PF00071 - Ras family

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2DPX
- X-ray MuPIT

2GJS
- X-ray MuPIT

3Q72
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
3Q7P - X-ray MuPIT 3Q7Q - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P55042
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005525 GTP binding

Biological Process:
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:1901841 regulation of high voltage-gated calcium channel activity
GO:1901842 negative regulation of high voltage-gated calcium channel activity

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  LF208263 - JP 2014500723-A/15766: Polycomb-Associated Non-Coding RNAs.
MA443840 - JP 2018138019-A/15766: Polycomb-Associated Non-Coding RNAs.
L24564 - Human Rad mRNA, complete cds.
BC011645 - Homo sapiens Ras-related associated with diabetes, mRNA (cDNA clone MGC:12812 IMAGE:4299345), complete cds.
BC057815 - Homo sapiens Ras-related associated with diabetes, mRNA (cDNA clone MGC:71750 IMAGE:30341066), complete cds.
JD196014 - Sequence 177038 from Patent EP1572962.
AK290613 - Homo sapiens cDNA FLJ75332 complete cds, highly similar to Homo sapiens Ras-related associated with diabetes (RRAD), mRNA.
JD375652 - Sequence 356676 from Patent EP1572962.
JD484629 - Sequence 465653 from Patent EP1572962.
JD470006 - Sequence 451030 from Patent EP1572962.
JD131645 - Sequence 112669 from Patent EP1572962.
JD230592 - Sequence 211616 from Patent EP1572962.
JD064894 - Sequence 45918 from Patent EP1572962.
JD480120 - Sequence 461144 from Patent EP1572962.
JD243947 - Sequence 224971 from Patent EP1572962.
JD258945 - Sequence 239969 from Patent EP1572962.
DQ891951 - Synthetic construct clone IMAGE:100004581; FLH181709.01X; RZPDo839G04136D Ras-related associated with diabetes (RRAD) gene, encodes complete protein.
DQ895137 - Synthetic construct Homo sapiens clone IMAGE:100009597; FLH181705.01L; RZPDo839G04135D Ras-related associated with diabetes (RRAD) gene, encodes complete protein.
KJ905311 - Synthetic construct Homo sapiens clone ccsbBroadEn_14835 RRAD-like gene, encodes complete protein.
AB464132 - Synthetic construct DNA, clone: pF1KB6415, Homo sapiens RRAD gene for Ras-related associated with diabetes, without stop codon, in Flexi system.
LF212225 - JP 2014500723-A/19728: Polycomb-Associated Non-Coding RNAs.
MA447802 - JP 2018138019-A/19728: Polycomb-Associated Non-Coding RNAs.
JD130909 - Sequence 111933 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_004165, P55042, Q96F39, RAD, RAD_HUMAN, uc002eqo.1, uc002eqo.2, uc002eqo.3, uc002eqo.4
UCSC ID: uc002eqo.4
RefSeq Accession: NM_004165
Protein: P55042 (aka RAD_HUMAN)
CCDS: CCDS10824.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.