Human Gene TRAPPC2L (ENST00000301021.7) Description and Page Index
Description: Homo sapiens trafficking protein particle complex 2 like (TRAPPC2L), transcript variant 2, mRNA. (from RefSeq NM_016209) RefSeq Summary (NM_016209): This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000301021.7 Gencode Gene: ENSG00000167515.10 Transcript (Including UTRs) Position: hg38 chr16:88,857,086-88,862,686 Size: 5,601 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr16:88,857,151-88,860,959 Size: 3,809 Coding Exon Count: 5
ID:TPC2L_HUMAN DESCRIPTION: RecName: Full=Trafficking protein particle complex subunit 2-like protein; FUNCTION: May play a role in vesicular transport from endoplasmic reticulum to Golgi. SUBUNIT: Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with the heterodimer TRAPPC3- TRAPPC6A. Interacts with TRAPPC6A. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. TISSUE SPECIFICITY: Expressed in testis, liver, bladder, lung, spleen and brain, several cell lines and primary chondrocytes cell line. SIMILARITY: Belongs to the TRAPP small subunits family. Sedlin subfamily. SEQUENCE CAUTION: Sequence=BAC86686.1; Type=Miscellaneous discrepancy; Note=Intron retention;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04628 - Sedlin, N-terminal conserved region
ModBase Predicted Comparative 3D Structure on Q9UL33
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.