Human Gene SEC61A2 (ENST00000304267.12) Description and Page Index
Description: Homo sapiens SEC61 translocon alpha 2 subunit (SEC61A2), transcript variant 3, mRNA. (from RefSeq NM_001142627) RefSeq Summary (NM_001142627): The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]. Gencode Transcript: ENST00000304267.12 Gencode Gene: ENSG00000065665.21 Transcript (Including UTRs) Position: hg38 chr10:12,129,701-12,169,956 Size: 40,256 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr10:12,129,788-12,169,327 Size: 39,540 Coding Exon Count: 12
ID:S61A2_HUMAN DESCRIPTION: RecName: Full=Protein transport protein Sec61 subunit alpha isoform 2; Short=Sec61 alpha-2; FUNCTION: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61- beta and SEC61-gamma (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the SecY/SEC61-alpha family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H9S3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB046850 - Homo sapiens mRNA for KIAA1630 protein, partial cds. AK301841 - Homo sapiens cDNA FLJ61445 complete cds, highly similar to Protein transport protein Sec61 subunit alpha isoform 2. AK292295 - Homo sapiens cDNA FLJ77369 complete cds, highly similar to Homo sapiens Sec61 alpha 2 subunit (SEC61A2), mRNA. BC026179 - Homo sapiens Sec61 alpha 2 subunit (S. cerevisiae), mRNA (cDNA clone MGC:32910 IMAGE:4823130), complete cds. AF346603 - Homo sapiens Sec61 alpha form 2 mRNA, complete cds. AK057532 - Homo sapiens cDNA FLJ32970 fis, clone TESTI2008840, highly similar to Protein transport protein Sec61 subunit alpha isoform 2. AK022640 - Homo sapiens cDNA FLJ12578 fis, clone NT2RM4001054, moderately similar to Homo sapiens sec61 homolog mRNA. JD458112 - Sequence 439136 from Patent EP1572962. JF432518 - Synthetic construct Homo sapiens clone IMAGE:100073740 Sec61 alpha 2 subunit (S. cerevisiae) (SEC61A2) gene, encodes complete protein. KJ902782 - Synthetic construct Homo sapiens clone ccsbBroadEn_12176 SEC61A2 gene, encodes complete protein. AK022027 - Homo sapiens cDNA FLJ11965 fis, clone HEMBB1001112, moderately similar to Homo sapiens sec61 homolog mRNA. AK001440 - Homo sapiens cDNA FLJ10578 fis, clone NT2RP2003433, highly similar to PROTEIN TRANSPORT PROTEIN SEC61 ALPHA SUBUNIT.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03060 - Protein export hsa05110 - Vibrio cholerae infection