Human Gene DBN1 (ENST00000309007.9) Description and Page Index
  Description: Homo sapiens drebrin 1 (DBN1), transcript variant 1, mRNA. (from RefSeq NM_004395)
RefSeq Summary (NM_004395): The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000309007.9
Gencode Gene: ENSG00000113758.13
Transcript (Including UTRs)
   Position: hg38 chr5:177,456,608-177,473,741 Size: 17,134 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr5:177,457,433-177,473,521 Size: 16,089 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:177,456,608-177,473,741)mRNA (may differ from genome)Protein (649 aa)
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HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DREB_HUMAN
DESCRIPTION: RecName: Full=Drebrin; AltName: Full=Developmentally-regulated brain protein;
FUNCTION: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.
SUBUNIT: Binds F-actin.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.
SIMILARITY: Contains 1 ADF-H domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: DBN1
Diseases sorted by gene-association score: alzheimer disease (4), down syndrome (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 40.90 RPKM in Cells - Transformed fibroblasts
Total median expression: 1086.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -116.70220-0.530 Picture PostScript Text
3' UTR -292.00825-0.354 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002108 - Actin-bd_cofilin/tropomyosin

Pfam Domains:
PF00241 - Cofilin/tropomyosin-type actin-binding protein

ModBase Predicted Comparative 3D Structure on Q16643
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0045296 cadherin binding

Biological Process:
GO:0007015 actin filament organization
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0010643 cell communication by chemical coupling
GO:0010644 cell communication by electrical coupling
GO:0030154 cell differentiation
GO:0032507 maintenance of protein location in cell
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048699 generation of neurons
GO:0050773 regulation of dendrite development
GO:0061351 neural precursor cell proliferation

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005921 gap junction
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030863 cortical cytoskeleton
GO:0042641 actomyosin
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  D17530 - Homo sapiens mRNA for drebrin E, complete cds.
U00802 - Human drebrin E2 mRNA (DBN1), complete cds.
BC000283 - Homo sapiens drebrin 1, mRNA (cDNA clone MGC:1517 IMAGE:3356428), complete cds.
BC007281 - Homo sapiens drebrin 1, mRNA (cDNA clone MGC:15625 IMAGE:3343626), complete cds.
AK094125 - Homo sapiens cDNA FLJ36806 fis, clone ASTRO1000165, highly similar to Drebrin.
AK225523 - Homo sapiens mRNA for drebrin 1 isoform a variant, clone: KAT04801.
BC007567 - Homo sapiens drebrin 1, mRNA (cDNA clone MGC:15517 IMAGE:3028196), complete cds.
AL110225 - Homo sapiens mRNA; cDNA DKFZp434D064 (from clone DKFZp434D064); partial cds.
KJ896689 - Synthetic construct Homo sapiens clone ccsbBroadEn_06083 DBN1 gene, encodes complete protein.
LC369599 - Homo sapiens DBN1 mRNA for drebrin A, complete cds.
AK314645 - Homo sapiens cDNA, FLJ95489, highly similar to Homo sapiens drebrin 1 (DBN1), transcript variant 1, mRNA.
AB463582 - Synthetic construct DNA, clone: pF1KB8355, Homo sapiens DBN1 gene for drebrin 1, without stop codon, in Flexi system.
AM393436 - Synthetic construct Homo sapiens clone IMAGE:100002514 for hypothetical protein (DBN1 gene).
JD497307 - Sequence 478331 from Patent EP1572962.
JD432730 - Sequence 413754 from Patent EP1572962.
JD210442 - Sequence 191466 from Patent EP1572962.
JD197495 - Sequence 178519 from Patent EP1572962.
JD130778 - Sequence 111802 from Patent EP1572962.
DQ571854 - Homo sapiens piRNA piR-31966, complete sequence.
JD313065 - Sequence 294089 from Patent EP1572962.
JD493447 - Sequence 474471 from Patent EP1572962.
JD225289 - Sequence 206313 from Patent EP1572962.
JD292253 - Sequence 273277 from Patent EP1572962.
JD550180 - Sequence 531204 from Patent EP1572962.
JD483909 - Sequence 464933 from Patent EP1572962.
JD394970 - Sequence 375994 from Patent EP1572962.
JD370548 - Sequence 351572 from Patent EP1572962.
AK295295 - Homo sapiens cDNA FLJ53620 complete cds, highly similar to Drebrin.
JD361989 - Sequence 343013 from Patent EP1572962.
JD241943 - Sequence 222967 from Patent EP1572962.
JD340344 - Sequence 321368 from Patent EP1572962.
BC114553 - Homo sapiens drebrin 1, mRNA (cDNA clone IMAGE:40053662), with apparent retained intron.
LF212531 - JP 2014500723-A/20034: Polycomb-Associated Non-Coding RNAs.
MA448108 - JP 2018138019-A/20034: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RBG0, D0S117E, DREB_HUMAN, NM_004395, Q16643, Q9UFZ5, uc003mgy.1, uc003mgy.2, uc003mgy.3
UCSC ID: uc003mgy.3
RefSeq Accession: NM_004395
Protein: Q16643 (aka DREB_HUMAN)
CCDS: CCDS4420.1, CCDS4421.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.