Human Gene DBN1 (ENST00000309007.9) Description and Page Index
Description: Homo sapiens drebrin 1 (DBN1), transcript variant 1, mRNA. (from RefSeq NM_004395) RefSeq Summary (NM_004395): The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000309007.9 Gencode Gene: ENSG00000113758.13 Transcript (Including UTRs) Position: hg38 chr5:177,456,608-177,473,741 Size: 17,134 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr5:177,457,433-177,473,521 Size: 16,089 Coding Exon Count: 14
ID:DREB_HUMAN DESCRIPTION: RecName: Full=Drebrin; AltName: Full=Developmentally-regulated brain protein; FUNCTION: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively. SUBUNIT: Binds F-actin. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. SIMILARITY: Contains 1 ADF-H domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00241 - Cofilin/tropomyosin-type actin-binding protein
ModBase Predicted Comparative 3D Structure on Q16643
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.