Human Gene YY1AP1 (ENST00000311573.9) Description and Page Index
Description: Enhances transcription activation by YY1. May play a role in cell cycle regulation. (from UniProt Q9H869) RefSeq Summary (NM_001198904): The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000311573.9 Gencode Gene: ENSG00000163374.19 Transcript (Including UTRs) Position: hg38 chr1:155,659,446-155,688,294 Size: 28,849 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr1:155,659,657-155,679,500 Size: 19,844 Coding Exon Count: 8
ID:YYAP1_HUMAN DESCRIPTION: RecName: Full=YY1-associated protein 1; AltName: Full=Hepatocellular carcinoma susceptibility protein; AltName: Full=Hepatocellular carcinoma-associated protein 2; FUNCTION: Enhances transcription activation by YY1. May play a role in cell cycle regulation. SUBUNIT: Interacts with YY1. Interacts with MAD2L2. INTERACTION: P54253:ATXN1; NbExp=4; IntAct=EBI-946122, EBI-930964; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas. SEQUENCE CAUTION: Sequence=BAA91871.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9H869
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.