Human Gene MOB3C (ENST00000319928.7) Description and Page Index
  Description: Homo sapiens MOB kinase activator 3C (MOB3C), transcript variant 2, mRNA. (from RefSeq NM_201403)
RefSeq Summary (NM_201403): The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000319928.7
Gencode Gene: ENSG00000142961.14
Transcript (Including UTRs)
   Position: hg38 chr1:46,607,715-46,616,891 Size: 9,177 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr1:46,609,655-46,613,321 Size: 3,667 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:46,607,715-46,616,891)mRNA (may differ from genome)Protein (216 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=MOB kinase activator 3C; AltName: Full=Mob1 homolog 2C; AltName: Full=Mps one binder kinase activator-like 2C;
FUNCTION: May regulate the activity of kinases (By similarity).
SIMILARITY: Belongs to the MOB1/phocein family.
SEQUENCE CAUTION: Sequence=BAC03434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC03752.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI14766.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.89 RPKM in Pancreas
Total median expression: 271.02 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.30231-0.452 Picture PostScript Text
3' UTR -697.001940-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005301 - Mob1_phocein

Pfam Domains:
PF03637 - Mob1/phocein family

ModBase Predicted Comparative 3D Structure on Q70IA8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0046872 metal ion binding

-  Descriptions from all associated GenBank mRNAs
  AK304005 - Homo sapiens cDNA FLJ59008 complete cds, highly similar to MAP kinase-interactingserine/threonine-protein kinase 1 (EC
BC026078 - Homo sapiens MOB1, Mps One Binder kinase activator-like 2C (yeast), mRNA (cDNA clone IMAGE:4827090).
AK091808 - Homo sapiens cDNA FLJ34489 fis, clone HLUNG2004534, weakly similar to MOB2 PROTEIN.
AX747196 - Sequence 721 from Patent EP1308459.
AK090453 - Homo sapiens mRNA for FLJ00374 protein.
JD477468 - Sequence 458492 from Patent EP1572962.
JD278198 - Sequence 259222 from Patent EP1572962.
JD466447 - Sequence 447471 from Patent EP1572962.
JD262216 - Sequence 243240 from Patent EP1572962.
JD303504 - Sequence 284528 from Patent EP1572962.
JD297906 - Sequence 278930 from Patent EP1572962.
JD410529 - Sequence 391553 from Patent EP1572962.
JD504637 - Sequence 485661 from Patent EP1572962.
JD513083 - Sequence 494107 from Patent EP1572962.
JD328354 - Sequence 309378 from Patent EP1572962.
JD436823 - Sequence 417847 from Patent EP1572962.
JD102961 - Sequence 83985 from Patent EP1572962.
JD372437 - Sequence 353461 from Patent EP1572962.
JD533044 - Sequence 514068 from Patent EP1572962.
JD439381 - Sequence 420405 from Patent EP1572962.
JD240056 - Sequence 221080 from Patent EP1572962.
JD524405 - Sequence 505429 from Patent EP1572962.
BC121169 - Homo sapiens MOB1, Mps One Binder kinase activator-like 2C (yeast), mRNA (cDNA clone MGC:150540 IMAGE:40122151), complete cds.
JD251456 - Sequence 232480 from Patent EP1572962.
JD262410 - Sequence 243434 from Patent EP1572962.
JD304402 - Sequence 285426 from Patent EP1572962.
JD084948 - Sequence 65972 from Patent EP1572962.
JD402139 - Sequence 383163 from Patent EP1572962.
JD393203 - Sequence 374227 from Patent EP1572962.
JD232554 - Sequence 213578 from Patent EP1572962.
JD083883 - Sequence 64907 from Patent EP1572962.
JD249133 - Sequence 230157 from Patent EP1572962.
JD378938 - Sequence 359962 from Patent EP1572962.
JD178240 - Sequence 159264 from Patent EP1572962.
JD400515 - Sequence 381539 from Patent EP1572962.
JD279721 - Sequence 260745 from Patent EP1572962.
JD490017 - Sequence 471041 from Patent EP1572962.
JD233373 - Sequence 214397 from Patent EP1572962.
JD229315 - Sequence 210339 from Patent EP1572962.
JD449660 - Sequence 430684 from Patent EP1572962.
JD044181 - Sequence 25205 from Patent EP1572962.
JD220521 - Sequence 201545 from Patent EP1572962.
JD154786 - Sequence 135810 from Patent EP1572962.
JD065185 - Sequence 46209 from Patent EP1572962.
JD104033 - Sequence 85057 from Patent EP1572962.
AJ580637 - Homo sapiens mRNA for Mob3C protein (MOB3C gene).
KJ900266 - Synthetic construct Homo sapiens clone ccsbBroadEn_09660 MOB3C gene, encodes complete protein.
KJ895627 - Synthetic construct Homo sapiens clone ccsbBroadEn_05021 MOB3C gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DQ22, MOB3C_HUMAN, MOBKL2C, NM_201403, Q0VA98, Q5TC10, Q5TC11, Q70IA8, Q8NAZ2, Q8NF28, uc001cqf.1, uc001cqf.2, uc001cqf.3, uc001cqf.4
UCSC ID: uc001cqf.4
RefSeq Accession: NM_201403
Protein: Q70IA8 (aka MOB3C_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.