Human Gene ATP11B (ENST00000323116.10) Description and Page Index
  Description: Homo sapiens ATPase phospholipid transporting 11B (putative) (ATP11B), mRNA. (from RefSeq NM_014616)
RefSeq Summary (NM_014616): P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.242189.1, SRR1803613.136294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323116.10/ ENSP00000321195.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000323116.10
Gencode Gene: ENSG00000058063.16
Transcript (Including UTRs)
   Position: hg38 chr3:182,793,504-182,921,629 Size: 128,126 Total Exon Count: 30 Strand: +
Coding Region
   Position: hg38 chr3:182,793,760-182,918,104 Size: 124,345 Coding Exon Count: 30 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:182,793,504-182,921,629)mRNA (may differ from genome)Protein (1177 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Probable phospholipid-transporting ATPase IF; EC=; AltName: Full=ATPase IR; AltName: Full=ATPase class VI type 11B;
CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
SUBUNIT: Interacts with TMEM30A.
SUBCELLULAR LOCATION: Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, mainly located in recycling endosomes.
SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
SEQUENCE CAUTION: Sequence=AAH10630.1; Type=Frameshift; Positions=884; Sequence=AAH42180.1; Type=Miscellaneous discrepancy; Note=Intron retention;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.76 RPKM in Esophagus - Mucosa
Total median expression: 320.39 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -149.90256-0.586 Picture PostScript Text
3' UTR -821.903525-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023306 - ATPase_cation_domN
IPR008250 - ATPase_P-typ_ATPase-assoc-dom
IPR023300 - ATPase_P-typ_cyto_domA
IPR023299 - ATPase_P-typ_cyto_domN
IPR001757 - ATPase_P-typ_ion-transptr
IPR018303 - ATPase_P-typ_P_site
IPR006539 - ATPase_P-typ_Plipid-transl
IPR005834 - Dehalogen-like_hydro
IPR023214 - HAD-like_dom

Pfam Domains:
PF00122 - E1-E2 ATPase
PF00702 - haloacid dehalogenase-like hydrolase

ModBase Predicted Comparative 3D Structure on Q9Y2G3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015075 ion transmembrane transporter activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006811 ion transport
GO:0006869 lipid transport
GO:0015914 phospholipid transport
GO:0015917 aminophospholipid transport
GO:0034220 ion transmembrane transport
GO:0043312 neutrophil degranulation
GO:0045332 phospholipid translocation

Cellular Component:
GO:0005637 nuclear inner membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035577 azurophil granule membrane
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane

-  Descriptions from all associated GenBank mRNAs
  LP895456 - Sequence 320 from Patent EP3253886.
AK296750 - Homo sapiens cDNA FLJ60651 complete cds, highly similar to Probable phospholipid-transporting ATPase IF(EC
AF156548 - Homo sapiens putative E1-E2 ATPase mRNA, partial cds.
AB527450 - Synthetic construct DNA, clone: pF1KB7354, Homo sapiens ATP11B gene for ATPase, class VI, type 11B, without stop codon, in Flexi system.
BC148558 - Synthetic construct Homo sapiens clone IMAGE:100015500, MGC:183063 ATPase, class VI, type 11B (ATP11B) mRNA, encodes complete protein.
BC042180 - Homo sapiens ATPase, class VI, type 11B, mRNA (cDNA clone IMAGE:5395206), complete cds.
JD127622 - Sequence 108646 from Patent EP1572962.
KJ902300 - Synthetic construct Homo sapiens clone ccsbBroadEn_11694 ATP11B gene, encodes complete protein.
AK304855 - Homo sapiens cDNA FLJ56374 complete cds, highly similar to Probable phospholipid-transporting ATPase IF(EC
JD227444 - Sequence 208468 from Patent EP1572962.
AK093727 - Homo sapiens cDNA FLJ36408 fis, clone THYMU2010094, highly similar to Probable phospholipid-transporting ATPase IF (EC
AX748279 - Sequence 1804 from Patent EP1308459.
AB023173 - Homo sapiens mRNA for KIAA0956 protein, partial cds.
BC010630 - Homo sapiens ATPase, class VI, type 11B, mRNA (cDNA clone IMAGE:3853179), partial cds.
BX537779 - Homo sapiens mRNA; cDNA DKFZp779H1459 (from clone DKFZp779H1459).
AL133061 - Homo sapiens mRNA; cDNA DKFZp434N1615 (from clone DKFZp434N1615); partial cds.
BC033880 - Homo sapiens ATPase, class VI, type 11B, mRNA (cDNA clone IMAGE:5548541), complete cds.
KJ902299 - Synthetic construct Homo sapiens clone ccsbBroadEn_11693 ATP11B gene, encodes complete protein.
DQ925668 - Homo sapiens clone 2-3 truncated ATPase 11B protein (ATP11B) mRNA, partial cds, alternatively spliced.
JD113153 - Sequence 94177 from Patent EP1572962.
JD277035 - Sequence 258059 from Patent EP1572962.
JD204587 - Sequence 185611 from Patent EP1572962.
JD304270 - Sequence 285294 from Patent EP1572962.
JD236049 - Sequence 217073 from Patent EP1572962.
JD302010 - Sequence 283034 from Patent EP1572962.
JD093756 - Sequence 74780 from Patent EP1572962.
JD305367 - Sequence 286391 from Patent EP1572962.
JD563807 - Sequence 544831 from Patent EP1572962.
JD315292 - Sequence 296316 from Patent EP1572962.
JD214232 - Sequence 195256 from Patent EP1572962.
JD549740 - Sequence 530764 from Patent EP1572962.
JD447494 - Sequence 428518 from Patent EP1572962.
JD347548 - Sequence 328572 from Patent EP1572962.
JD282325 - Sequence 263349 from Patent EP1572962.
JD088800 - Sequence 69824 from Patent EP1572962.
JD201968 - Sequence 182992 from Patent EP1572962.
JD166316 - Sequence 147340 from Patent EP1572962.
JD311439 - Sequence 292463 from Patent EP1572962.
JD162907 - Sequence 143931 from Patent EP1572962.
JD114755 - Sequence 95779 from Patent EP1572962.
JD321204 - Sequence 302228 from Patent EP1572962.
JD388622 - Sequence 369646 from Patent EP1572962.
JD174458 - Sequence 155482 from Patent EP1572962.
JD298173 - Sequence 279197 from Patent EP1572962.
JD258580 - Sequence 239604 from Patent EP1572962.
JD379219 - Sequence 360243 from Patent EP1572962.
JD502305 - Sequence 483329 from Patent EP1572962.
JD303205 - Sequence 284229 from Patent EP1572962.
JD265830 - Sequence 246854 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y2G3 (Reactome details) participates in the following event(s):

R-HSA-6798739 Exocytosis of azurophil granule membrane proteins
R-HSA-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane
R-HSA-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane
R-HSA-6798695 Neutrophil degranulation
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-168249 Innate Immune System
R-HSA-983712 Ion channel transport
R-HSA-168256 Immune System
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: AT11B_HUMAN, ATPIF, ATPIR, KIAA0956, NM_014616, Q96FN1, Q9UKK7, Q9Y2G3, uc003flb.1, uc003flb.2, uc003flb.3, uc003flb.4, uc003flb.5
UCSC ID: uc003flb.5
RefSeq Accession: NM_014616
Protein: Q9Y2G3 (aka AT11B_HUMAN or A11B_HUMAN)
CCDS: CCDS33896.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.