Human Gene ATP11B (ENST00000323116.10) Description and Page Index
Description: Homo sapiens ATPase phospholipid transporting 11B (putative) (ATP11B), mRNA. (from RefSeq NM_014616) RefSeq Summary (NM_014616): P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.242189.1, SRR1803613.136294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323116.10/ ENSP00000321195.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000323116.10 Gencode Gene: ENSG00000058063.16 Transcript (Including UTRs) Position: hg38 chr3:182,793,504-182,921,629 Size: 128,126 Total Exon Count: 30 Strand: + Coding Region Position: hg38 chr3:182,793,760-182,918,104 Size: 124,345 Coding Exon Count: 30
ID:AT11B_HUMAN DESCRIPTION: RecName: Full=Probable phospholipid-transporting ATPase IF; EC=22.214.171.124; AltName: Full=ATPase IR; AltName: Full=ATPase class VI type 11B; CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out). SUBUNIT: Interacts with TMEM30A. SUBCELLULAR LOCATION: Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, mainly located in recycling endosomes. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. SEQUENCE CAUTION: Sequence=AAH10630.1; Type=Frameshift; Positions=884; Sequence=AAH42180.1; Type=Miscellaneous discrepancy; Note=Intron retention;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2G3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.