Human Gene DNAI3 (ENST00000326813.12) from GENCODE V38
  Description: Homo sapiens dynein axonemal intermediate chain 3 (DNAI3), transcript variant 2, mRNA. (from RefSeq NM_001288563)
Gencode Transcript: ENST00000326813.12
Gencode Gene: ENSG00000162643.13
Transcript (Including UTRs)
   Position: hg38 chr1:85,062,312-85,133,138 Size: 70,827 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg38 chr1:85,071,942-85,132,998 Size: 61,057 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:85,062,312-85,133,138)mRNA (may differ from genome)Protein (852 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDMGIneXtProt
OMIMPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: WDR63_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 63; AltName: Full=Testis development protein NYD-SP29;
SIMILARITY: Contains 5 WD repeats.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.95 RPKM in Testis
Total median expression: 22.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.70189-0.305 Picture PostScript Text
3' UTR -22.40140-0.160 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on Q8IWG1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0045503 dynein light chain binding
GO:0045504 dynein heavy chain binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0030286 dynein complex


-  Descriptions from all associated GenBank mRNAs
  BX648851 - Homo sapiens mRNA; cDNA DKFZp686G05231 (from clone DKFZp686G05231).
HM005538 - Homo sapiens clone HTL-T-225 testicular tissue protein Li 225 mRNA, complete cds.
AY049724 - Homo sapiens testis development protein NYD-SP29 mRNA, complete cds.
AK292603 - Homo sapiens cDNA FLJ75315 complete cds, highly similar to Homo sapiens WD repeat domain 63, mRNA.
AK054629 - Homo sapiens cDNA FLJ30067 fis, clone ASTRO1000018, weakly similar to DYNEIN INTERMEDIATE CHAIN 3, CILIARY.
BC040265 - Homo sapiens WD repeat domain 63, mRNA (cDNA clone MGC:35051 IMAGE:5165779), complete cds.
JD300091 - Sequence 281115 from Patent EP1572962.
KJ895425 - Synthetic construct Homo sapiens clone ccsbBroadEn_04819 WDR63 gene, encodes complete protein.
JD182915 - Sequence 163939 from Patent EP1572962.
JD165172 - Sequence 146196 from Patent EP1572962.
JD392061 - Sequence 373085 from Patent EP1572962.
JD359709 - Sequence 340733 from Patent EP1572962.
JD553307 - Sequence 534331 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K988, ENST00000326813.1, ENST00000326813.10, ENST00000326813.11, ENST00000326813.2, ENST00000326813.3, ENST00000326813.4, ENST00000326813.5, ENST00000326813.6, ENST00000326813.7, ENST00000326813.8, ENST00000326813.9, NM_001288563, Q8IWG1, Q96L72, Q96NU4, uc009wcl.1, uc009wcl.2, uc009wcl.3, uc009wcl.4, uc009wcl.5, WDR63, WDR63_HUMAN
UCSC ID: ENST00000326813.12
RefSeq Accession: NM_001288563
Protein: Q8IWG1 (aka WDR63_HUMAN)
CCDS: CCDS702.1, CCDS72818.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.