Human Gene DNAI3 (ENST00000326813.12) from GENCODE V38
  Description: Homo sapiens dynein axonemal intermediate chain 3 (DNAI3), transcript variant 2, mRNA. (from RefSeq NM_001288563)
Gencode Transcript: ENST00000326813.12
Gencode Gene: ENSG00000162643.13
Transcript (Including UTRs)
   Position: hg38 chr1:85,062,312-85,133,138 Size: 70,827 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg38 chr1:85,071,942-85,132,998 Size: 61,057 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:85,062,312-85,133,138)mRNA (may differ from genome)Protein (852 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDMGIneXtProt

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=WD repeat-containing protein 63; AltName: Full=Testis development protein NYD-SP29;
SIMILARITY: Contains 5 WD repeats.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.95 RPKM in Testis
Total median expression: 22.96 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.70189-0.305 Picture PostScript Text
3' UTR -22.40140-0.160 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on Q8IWG1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0045503 dynein light chain binding
GO:0045504 dynein heavy chain binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0030286 dynein complex

-  Descriptions from all associated GenBank mRNAs
  BX648851 - Homo sapiens mRNA; cDNA DKFZp686G05231 (from clone DKFZp686G05231).
HM005538 - Homo sapiens clone HTL-T-225 testicular tissue protein Li 225 mRNA, complete cds.
AY049724 - Homo sapiens testis development protein NYD-SP29 mRNA, complete cds.
AK292603 - Homo sapiens cDNA FLJ75315 complete cds, highly similar to Homo sapiens WD repeat domain 63, mRNA.
AK054629 - Homo sapiens cDNA FLJ30067 fis, clone ASTRO1000018, weakly similar to DYNEIN INTERMEDIATE CHAIN 3, CILIARY.
BC040265 - Homo sapiens WD repeat domain 63, mRNA (cDNA clone MGC:35051 IMAGE:5165779), complete cds.
JD300091 - Sequence 281115 from Patent EP1572962.
KJ895425 - Synthetic construct Homo sapiens clone ccsbBroadEn_04819 WDR63 gene, encodes complete protein.
JD182915 - Sequence 163939 from Patent EP1572962.
JD165172 - Sequence 146196 from Patent EP1572962.
JD392061 - Sequence 373085 from Patent EP1572962.
JD359709 - Sequence 340733 from Patent EP1572962.
JD553307 - Sequence 534331 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K988, ENST00000326813.1, ENST00000326813.10, ENST00000326813.11, ENST00000326813.2, ENST00000326813.3, ENST00000326813.4, ENST00000326813.5, ENST00000326813.6, ENST00000326813.7, ENST00000326813.8, ENST00000326813.9, NM_001288563, Q8IWG1, Q96L72, Q96NU4, uc009wcl.1, uc009wcl.2, uc009wcl.3, uc009wcl.4, uc009wcl.5, WDR63, WDR63_HUMAN
UCSC ID: ENST00000326813.12
RefSeq Accession: NM_001288563
Protein: Q8IWG1 (aka WDR63_HUMAN)
CCDS: CCDS702.1, CCDS72818.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.