Human Gene LRRC8B (ENST00000330947.7) from GENCODE V38
Description: Homo sapiens leucine rich repeat containing 8 VRAC subunit B (LRRC8B), transcript variant 4, mRNA. (from RefSeq NM_001369819)
Gencode Transcript: ENST00000330947.7
Gencode Gene: ENSG00000197147.15
Transcript (Including UTRs)
Position: hg38 chr1:89,524,829-89,597,861 Size: 73,033 Total Exon Count: 6 Strand: +
Position: hg38 chr1:89,582,651-89,593,043 Size: 10,393 Coding Exon Count: 2
Data last updated at UCSC: 2021-09-27 09:51:20
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 8B; AltName: Full=T-cell activation leucine repeat-rich protein; Short=TA-LRRP;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Contains 13 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=BAA13220.2; Type=Erroneous initiation;
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR021040 - LRR_protein-8_N
Pfam Domains: PF12534 - Pannexin-like TM region of LRRC8
PF00560 - Leucine Rich Repeat
ModBase Predicted Comparative 3D Structure on Q6P9F7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC060782 - Homo sapiens leucine rich repeat containing 8 family, member B, mRNA (cDNA clone MGC:71558 IMAGE:5298560), complete cds. GQ900915 - Homo sapiens clone HEL-T-27 epididymis secretory sperm binding protein mRNA, complete cds. BC030607 - Homo sapiens leucine rich repeat containing 8 family, member B, mRNA (cDNA clone MGC:26970 IMAGE:4824652), complete cds. D86984 - Homo sapiens KIAA0231 mRNA for KIAA0231 protein. AF385436 - Homo sapiens T-cell activation leucine repeat-rich protein mRNA, complete cds. JD266185 - Sequence 247209 from Patent EP1572962. AY640232 - Homo sapiens HSD-43 mRNA, complete cds. JD553884 - Sequence 534908 from Patent EP1572962. CU688940 - Synthetic construct Homo sapiens gateway clone IMAGE:100020099 5' read LRRC8B mRNA. AB384447 - Synthetic construct DNA, clone: pF1KA0231, Homo sapiens LRRC8B gene for leucine-rich repeat-containing protein 8B, complete cds, without stop codon, in Flexi system. KJ898498 - Synthetic construct Homo sapiens clone ccsbBroadEn_07892 LRRC8B gene, encodes complete protein. GQ891292 - Homo sapiens clone HEL-S-15a epididymis secretory sperm binding protein mRNA, complete cds. BC037831 - Homo sapiens leucine rich repeat containing 8 family, member B, mRNA (cDNA clone IMAGE:4812407), complete cds. JD101870 - Sequence 82894 from Patent EP1572962. JD481194 - Sequence 462218 from Patent EP1572962. JD471784 - Sequence 452808 from Patent EP1572962. JD380620 - Sequence 361644 from Patent EP1572962. JD380621 - Sequence 361645 from Patent EP1572962. JD288981 - Sequence 270005 from Patent EP1572962. JD522412 - Sequence 503436 from Patent EP1572962. JD320079 - Sequence 301103 from Patent EP1572962. JD375442 - Sequence 356466 from Patent EP1572962. JD080429 - Sequence 61453 from Patent EP1572962. JD159038 - Sequence 140062 from Patent EP1572962. JD275770 - Sequence 256794 from Patent EP1572962. JD208844 - Sequence 189868 from Patent EP1572962. JD119101 - Sequence 100125 from Patent EP1572962. JD278352 - Sequence 259376 from Patent EP1572962. JD144619 - Sequence 125643 from Patent EP1572962. JD283339 - Sequence 264363 from Patent EP1572962. JD135507 - Sequence 116531 from Patent EP1572962. JD135506 - Sequence 116530 from Patent EP1572962. JD497595 - Sequence 478619 from Patent EP1572962. JD238415 - Sequence 219439 from Patent EP1572962. JD047733 - Sequence 28757 from Patent EP1572962. JD472284 - Sequence 453308 from Patent EP1572962. JD108887 - Sequence 89911 from Patent EP1572962. JD458036 - Sequence 439060 from Patent EP1572962. JD176561 - Sequence 157585 from Patent EP1572962. JD066825 - Sequence 47849 from Patent EP1572962. JD184209 - Sequence 165233 from Patent EP1572962. JD093092 - Sequence 74116 from Patent EP1572962. JD561446 - Sequence 542470 from Patent EP1572962. JD282015 - Sequence 263039 from Patent EP1572962. JD269727 - Sequence 250751 from Patent EP1572962. JD189890 - Sequence 170914 from Patent EP1572962. JD221265 - Sequence 202289 from Patent EP1572962. JD550077 - Sequence 531101 from Patent EP1572962. JD510748 - Sequence 491772 from Patent EP1572962. BC035081 - Homo sapiens cDNA clone IMAGE:5260685. JD025236 - Sequence 6260 from Patent EP1572962. JD031893 - Sequence 12917 from Patent EP1572962. AY358112 - Homo sapiens clone DNA161005 ITLT6413 (UNQ6413) mRNA, complete cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein Q6P9F7 ( Reactome details) participates in the following event(s): R-HSA-8941543 VRAC heteromer transports I-, Cl- from cytosol to extracellular region
R-HSA-5223345 Miscellaneous transport and binding events
R-HSA-382551 Transport of small molecules
Other Names for This Gene
Alternate Gene Symbols: D3DT28, ENST00000330947.1, ENST00000330947.2, ENST00000330947.3, ENST00000330947.4, ENST00000330947.5, ENST00000330947.6, KIAA0231, LRC8B_HUMAN, NM_001369819, Q6P9F7, Q6UY21, Q8N106, Q92627, uc057ieo.1, uc057ieo.2, UNQ6413/PRO21207 UCSC ID: ENST00000330947.7 RefSeq Accession: NM_001369817
(aka LRC8B_HUMAN) Q6P9F7
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.