Human Gene TAS1R1 (ENST00000333172.11) from GENCODE V44
Description: Homo sapiens taste 1 receptor member 1 (TAS1R1), transcript variant 2, mRNA. (from RefSeq NM_138697) RefSeq Summary (NM_138697): The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000333172.11 Gencode Gene: ENSG00000173662.21 Transcript (Including UTRs) Position: hg38 chr1:6,555,307-6,579,755 Size: 24,449 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr1:6,555,374-6,579,584 Size: 24,211 Coding Exon Count: 6
ID:TS1R1_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 1 member 1; AltName: Full=G-protein coupled receptor 70; Flags: Precursor; FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. SUBUNIT: Forms heterodimers with TAS1R3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. SEQUENCE CAUTION: Sequence=AAL91359.1; Type=Erroneous initiation; Sequence=AAL91360.1; Type=Erroneous initiation; Sequence=AAL91361.1; Type=Erroneous initiation; Sequence=BAC05845.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Protein Spotlight; Note=The taste experience - Issue 55 of February 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt055.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPR PF01094 - Receptor family ligand binding region PF07562 - Nine Cysteines Domain of family 3 GPCR
ModBase Predicted Comparative 3D Structure on Q7RTX1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.