Human Gene CACNA1C (ENST00000335762.9) Description and Page Index
Description: Membrane; Multi-pass membrane protein (By similarity). (from UniProt F5H522) RefSeq Summary (NM_001129834): This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]. Gencode Transcript: ENST00000335762.9 Gencode Gene: ENSG00000151067.22 Transcript (Including UTRs) Position: hg38 chr12:2,053,298-2,691,410 Size: 638,113 Total Exon Count: 48 Strand: + Coding Region Position: hg38 chr12:2,053,563-2,691,199 Size: 637,637 Coding Exon Count: 48
ID:F5H522_HUMAN DESCRIPTION: SubName: Full=Voltage-dependent L-type calcium channel subunit alpha-1C; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08763 - Voltage gated calcium channel IQ domain PF00520 - Ion transport protein
ModBase Predicted Comparative 3D Structure on F5H522
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.