ID:BCAP_HUMAN DESCRIPTION: RecName: Full=Phosphoinositide 3-kinase adapter protein 1; AltName: Full=B-cell adapter for phosphoinositide 3-kinase; AltName: Full=B-cell phosphoinositide 3-kinase adapter protein 1; FUNCTION: Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity). May be involved in the survival of mature B-cells via activation of REL (By similarity). SUBUNIT: Self-associates (By similarity). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain). Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). TISSUE SPECIFICITY: Expressed in natural killer (NK) cells. DOMAIN: The DBB domain is required for dimerization (By similarity). PTM: Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity). Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity). Phosphorylated on tyrosine residues in C-terminus region by ABL1 and V-abl. SIMILARITY: Contains 1 DBB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZUJ8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK122584 - Homo sapiens mRNA for FLJ00308 protein. BX648550 - Homo sapiens mRNA; cDNA DKFZp779E2431 (from clone DKFZp779E2431). AK092883 - Homo sapiens cDNA FLJ35564 fis, clone SPLEN2005416. AX747788 - Sequence 1313 from Patent EP1308459. AK125635 - Homo sapiens cDNA FLJ43647 fis, clone SYNOV4000706, moderately similar to Mus musculus phosphoinositide-3-kinase adaptor protein 1 (Pik3ap1). BC029917 - Homo sapiens phosphoinositide-3-kinase adaptor protein 1, mRNA (cDNA clone MGC:35132 IMAGE:5168493), complete cds. KJ903676 - Synthetic construct Homo sapiens clone ccsbBroadEn_13070 PIK3AP1 gene, encodes complete protein. AM393069 - Synthetic construct Homo sapiens clone IMAGE:100002318 for hypothetical protein (PIK3AP1 gene). JD022667 - Sequence 3691 from Patent EP1572962. JD030543 - Sequence 11567 from Patent EP1572962. JD019340 - Sequence 364 from Patent EP1572962. JD032850 - Sequence 13874 from Patent EP1572962. JD545745 - Sequence 526769 from Patent EP1572962. JD527246 - Sequence 508270 from Patent EP1572962. JD299712 - Sequence 280736 from Patent EP1572962. JD521849 - Sequence 502873 from Patent EP1572962. JD278947 - Sequence 259971 from Patent EP1572962. JD202716 - Sequence 183740 from Patent EP1572962. JD305324 - Sequence 286348 from Patent EP1572962. JD094281 - Sequence 75305 from Patent EP1572962. JD523978 - Sequence 505002 from Patent EP1572962. JD066330 - Sequence 47354 from Patent EP1572962. JD040708 - Sequence 21732 from Patent EP1572962. JD237594 - Sequence 218618 from Patent EP1572962. JD091572 - Sequence 72596 from Patent EP1572962. JD080634 - Sequence 61658 from Patent EP1572962. JD048788 - Sequence 29812 from Patent EP1572962. JD115714 - Sequence 96738 from Patent EP1572962. CU688788 - Synthetic construct Homo sapiens gateway clone IMAGE:100019254 5' read PIK3AP1 mRNA. JD137827 - Sequence 118851 from Patent EP1572962. JD421164 - Sequence 402188 from Patent EP1572962. JD263799 - Sequence 244823 from Patent EP1572962. JD324573 - Sequence 305597 from Patent EP1572962. JD227948 - Sequence 208972 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04662 - B cell receptor signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein Q6ZUJ8 (Reactome details) participates in the following event(s):
R-HSA-2045911 BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3 R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983705 Signaling by the B Cell Receptor (BCR) R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-1257604 PIP3 activates AKT signaling R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-9006925 Intracellular signaling by second messengers R-HSA-199418 Negative regulation of the PI3K/AKT network R-HSA-5663202 Diseases of signal transduction R-HSA-162582 Signal Transduction R-HSA-1643685 Disease
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