Human Gene UBE4B (ENST00000343090.11) from GENCODE V38
Description: Homo sapiens ubiquitination factor E4B (UBE4B), transcript variant 1, mRNA. (from RefSeq NM_001105562) RefSeq Summary (NM_001105562): The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000343090.11 Gencode Gene: ENSG00000130939.20 Transcript (Including UTRs) Position: hg38 chr1:10,032,958-10,181,239 Size: 148,282 Total Exon Count: 28 Strand: + Coding Region Position: hg38 chr1:10,033,671-10,179,956 Size: 146,286 Coding Exon Count: 28
ID:UBE4B_HUMAN DESCRIPTION: RecName: Full=Ubiquitin conjugation factor E4 B; AltName: Full=Homozygously deleted in neuroblastoma 1; AltName: Full=Ubiquitin fusion degradation protein 2; FUNCTION: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity). SUBUNIT: Interacts with VCP (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen. PTM: Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7. SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family. SIMILARITY: Contains 1 U-box domain. SEQUENCE CAUTION: Sequence=BAA31659.3; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95155
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0003222 ventricular trabecula myocardium morphogenesis GO:0006511 ubiquitin-dependent protein catabolic process GO:0006513 protein monoubiquitination GO:0008626 granzyme-mediated apoptotic signaling pathway GO:0009411 response to UV GO:0016567 protein ubiquitination GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0031175 neuron projection development GO:0034976 response to endoplasmic reticulum stress GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0044257 cellular protein catabolic process GO:0051865 protein autoubiquitination