Human Gene ICMT (ENST00000343813.10) from GENCODE V44
Description: Homo sapiens isoprenylcysteine carboxyl methyltransferase (ICMT), mRNA. (from RefSeq NM_012405) RefSeq Summary (NM_012405): This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000343813.10 Gencode Gene: ENSG00000116237.16 Transcript (Including UTRs) Position: hg38 chr1:6,221,193-6,235,964 Size: 14,772 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr1:6,225,080-6,235,911 Size: 10,832 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04140 - Isoprenylcysteine carboxyl methyltransferase (ICMT) family
ModBase Predicted Comparative 3D Structure on O60725
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
R-HSA-6788650 ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins