Human Gene TNFRSF25 (ENST00000348333.7) from GENCODE V43
  Description: Homo sapiens TNF receptor superfamily member 25 (TNFRSF25), transcript variant 4, mRNA. (from RefSeq NM_148967)
RefSeq Summary (NM_148967): The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000348333.7
Gencode Gene: ENSG00000215788.11
Transcript (Including UTRs)
   Position: hg38 chr1:6,461,434-6,466,107 Size: 4,674 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr1:6,461,434-6,466,107 Size: 4,674 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-02-17 13:02:02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:6,461,434-6,466,107)mRNA (may differ from genome)Protein (372 aa)
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HGNCHPRDLynxMGIneXtProtOMIM
PubMedReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TNR25_HUMAN
DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 25; AltName: Full=Apo-3; AltName: Full=Apoptosis-inducing receptor AIR; AltName: Full=Apoptosis-mediating receptor DR3; AltName: Full=Apoptosis-mediating receptor TRAMP; AltName: Full=Death receptor 3; AltName: Full=Lymphocyte-associated receptor of death; Short=LARD; AltName: Full=Protein WSL; AltName: Full=Protein WSL-1; Flags: Precursor;
FUNCTION: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
SUBUNIT: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 9: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 11: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 3: Secreted.
SUBCELLULAR LOCATION: Isoform 4: Secreted.
SUBCELLULAR LOCATION: Isoform 5: Secreted.
SUBCELLULAR LOCATION: Isoform 6: Secreted.
SUBCELLULAR LOCATION: Isoform 7: Secreted.
SUBCELLULAR LOCATION: Isoform 8: Secreted.
SUBCELLULAR LOCATION: Isoform 10: Secreted.
SUBCELLULAR LOCATION: Isoform 12: Secreted.
TISSUE SPECIFICITY: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
PTM: Glycosylated (Probable).
SIMILARITY: Contains 1 death domain.
SIMILARITY: Contains 4 TNFR-Cys repeats.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf25/";

-  Primer design for this transcript
 

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-  MalaCards Disease Associations
  MalaCards Gene Search: TNFRSF25
Diseases sorted by gene-association score: diabetes mellitus, insulin-dependent, 18 (10), haemophilus meningitis (10), diabetes mellitus, insulin-dependent, 17 (9), punctate epithelial keratoconjunctivitis (9), autoimmune disease of gastrointestinal tract (8), juvenile dermatitis herpetiformis (8), heart block, congenital (8), superficial keratitis (7), adrenal cortical hypofunction (7), herpes gestationis (7), autoimmune disease of endocrine system (7), jejunal adenocarcinoma (7), childhood type dermatomyositis (6), diffuse scleroderma (6), adie pupil (6), diabetes mellitus, insulin-dependent, 2 (6), autoimmune disease of skin and connective tissue (6), diabetes mellitus, insulin-dependent, 11 (6), immunoglobulin alpha deficiency (6), diabetes mellitus, insulin-dependent, 5 (5), hypersensitivity reaction disease (5), malignant essential hypertension (5), ascending cholangitis (5), toxic diffuse goiter (4), neuromuscular junction disease (4), diabetes mellitus, insulin-dependent (2), immune system disease (1), cholangitis, primary sclerosing (1), glucose metabolism disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 158.76 RPKM in Brain - Cerebellum
Total median expression: 746.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000488 - Death
IPR011029 - DEATH-like
IPR001368 - TNFR/NGFR_Cys_rich_reg
IPR022329 - TNFR_25

Pfam Domains:
PF00531 - Death domain

ModBase Predicted Comparative 3D Structure on Q93038
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0038023 signaling receptor activity

Biological Process:
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organism development
GO:0032496 response to lipopolysaccharide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042981 regulation of apoptotic process
GO:0097190 apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK226112 - Homo sapiens mRNA for ATP-binding cassette, sub-family A, member 2 isoform a variant, clone: hg01099.
U75380 - Human apoptosis-mediating receptor TRAMP mRNA, partial cds.
AY358309 - Homo sapiens clone DNA58801 DR3 (UNQ455) mRNA, complete cds.
U83597 - Human death domain receptor 3 (DDR3) mRNA, partial cds.
AK094488 - Homo sapiens cDNA FLJ37169 fis, clone BRACE2027770, highly similar to WSL-1 PROTEIN PRECURSOR.
AK094463 - Homo sapiens cDNA FLJ37144 fis, clone BRACE2024610, highly similar to Tumor necrosis factor receptor superfamily member 25 precursor.
U74611 - Human Apo-3 mRNA, complete cds.
AF026070 - Homo sapiens death receptor 3 beta (DR3) mRNA, complete cds.
AF026071 - Homo sapiens soluble death receptor 3 beta (DR3) mRNA, complete cds.
Y09392 - H.sapiens mRNA for WSL-LR, WSL-S1 and WSL-S2 proteins.
BC117189 - Homo sapiens tumor necrosis factor receptor superfamily, member 25, mRNA (cDNA clone MGC:150798 IMAGE:40125740), complete cds.
BC143886 - Homo sapiens tumor necrosis factor receptor superfamily, member 25, mRNA (cDNA clone MGC:177419 IMAGE:9052402), complete cds.
JD327061 - Sequence 308085 from Patent EP1572962.
U72763 - Human death receptor 3 (DR3) mRNA, complete cds.
U78029 - Human aoptosis inducing receptor AIR mRNA, complete cds.
U94501 - Human lymphocyte associated receptor of death 1a mRNA, complete cds.
U94502 - Human lymphocyte associated receptor of death 1b mRNA, alternatively spliced, complete cds.
U94503 - Human lymphocyte associated receptor of death 2 mRNA, alternatively spliced, complete cds.
U94504 - Human lymphocyte associated receptor of death 3 mRNA, alternatively spliced, complete cds.
U94505 - Human lymphocyte associated receptor of death 4 mRNA, alternatively spliced, complete cds.
U94506 - Human lymphocyte associated receptor of death 5 mRNA, alternatively spliced, complete cds.
U94507 - Human lymphocyte associated receptor of death 6 mRNA, alternatively spliced, complete cds.
U94508 - Human lymphocyte associated receptor of death 7 mRNA, alternatively spliced, complete cds.
U94509 - Human lymphocyte associated receptor of death 8 mRNA, alternatively spliced, complete cds.
U94510 - Human lymphocyte associated receptor of death 9 mRNA, alternatively spliced, complete cds.
JD175084 - Sequence 156108 from Patent EP1572962.
HQ258574 - Synthetic construct Homo sapiens clone IMAGE:100073099 tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 2 (TNFRSF25) gene, encodes complete protein.
AB590587 - Synthetic construct DNA, clone: pFN21AE1895, Homo sapiens TNFRSF25 gene for tumor necrosis factor receptor superfamily, member 25, without stop codon, in Flexi system.
JD443569 - Sequence 424593 from Patent EP1572962.
JD479840 - Sequence 460864 from Patent EP1572962.
JD058270 - Sequence 39294 from Patent EP1572962.
JD258696 - Sequence 239720 from Patent EP1572962.
JD456560 - Sequence 437584 from Patent EP1572962.
JD106346 - Sequence 87370 from Patent EP1572962.
AB308321 - Homo sapiens TNFRSF25 mRNA for tumor necrosis factor receptor superfamily member 25 deletion mutant, complete cds.
U83598 - Human death domain receptor 3 soluble form (DDR3) mRNA, partial cds.
U75381 - Human apoptosis-mediating receptor TRAMP ex mRNA, alternatively spliced, partial cds.
U94512 - Human lymphocyte associated receptor of death 11 mRNA, alternatively spliced, partial cds.
U83600 - Human death domain receptor 3 (DDR3) mRNA, alternatively spliced form 2, partial cds.
AK131074 - Homo sapiens mRNA for FLJ00260 protein.
AB018263 - Homo sapiens KIAA0720 mRNA for KIAA0720 protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction

BioCarta from NCI Cancer Genome Anatomy Project
h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors

Reactome (by CSHL, EBI, and GO)

Protein Q93038 (Reactome details) participates in the following event(s):

R-HSA-5693012 TNFSF15 binds TNFRSF25
R-HSA-5669034 TNFs bind their physiological receptors
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: APO3, B1ALX2, B1ALX3, B7ZLL7, DDR3, DR3, ENST00000348333.1, ENST00000348333.2, ENST00000348333.3, ENST00000348333.4, ENST00000348333.5, ENST00000348333.6, NM_148967, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q17RU4, Q92983, Q93036, Q93037, Q93038, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5, TNFRSF12, TNR25_HUMAN, uc001ang.1, uc001ang.2, uc001ang.3, uc001ang.4, UNQ455/PRO779, WSL, WSL1
UCSC ID: ENST00000348333.7
RefSeq Accession: NM_148967
Protein: Q93038 (aka TNR25_HUMAN or TR25_HUMAN)
CCDS: CCDS74.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.