Human Gene TMEM25 (ENST00000354284.8) Description and Page Index
  Description: Homo sapiens transmembrane protein 25 (TMEM25), transcript variant 4, mRNA. (from RefSeq NM_001144037)
Gencode Transcript: ENST00000354284.8
Gencode Gene: ENSG00000149582.16
Transcript (Including UTRs)
   Position: hg38 chr11:118,531,199-118,546,484 Size: 15,286 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr11:118,531,802-118,546,147 Size: 14,346 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:118,531,199-118,546,484)mRNA (may differ from genome)Protein (351 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 25; Flags: Precursor;
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 2: Secreted (Potential).
SUBCELLULAR LOCATION: Isoform 3: Secreted (Potential).
SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.56 RPKM in Brain - Cerebellum
Total median expression: 387.93 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.9063-0.411 Picture PostScript Text
3' UTR -120.70337-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013162 - CD80_C2-set
IPR007110 - Ig-like
IPR013783 - Ig-like_fold

Pfam Domains:
PF08205 - CD80-like C2-set immunoglobulin domain

ModBase Predicted Comparative 3D Structure on Q86YD3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK075437 - Homo sapiens cDNA PSEC0128 fis, clone PLACE1004113.
AK293670 - Homo sapiens cDNA FLJ57262 complete cds, highly similar to Transmembrane protein 25 precursor.
AK027305 - Homo sapiens cDNA FLJ14399 fis, clone HEMBA1003711.
AK297255 - Homo sapiens cDNA FLJ60685 complete cds, highly similar to Transmembrane protein 25 precursor.
AK292359 - Homo sapiens cDNA FLJ77182 complete cds, highly similar to Homo sapiens transmembrane protein 25, mRNA.
AK056325 - Homo sapiens cDNA FLJ31763 fis, clone NT2RI2007827.
AK124814 - Homo sapiens cDNA FLJ42824 fis, clone BRCAN2016433.
AK225415 - Homo sapiens mRNA for transmembrane protein 25 variant, clone: HRC06184.
AK096260 - Homo sapiens cDNA FLJ38941 fis, clone NT2NE2015974.
AY358919 - Homo sapiens clone DNA96850 ALPP2531 (UNQ2531) mRNA, complete cds.
BC042896 - Homo sapiens transmembrane protein 25, mRNA (cDNA clone MGC:34083 IMAGE:5168151), complete cds.
BC051841 - Homo sapiens transmembrane protein 25, mRNA (cDNA clone MGC:60150 IMAGE:5725777), complete cds.
JD130772 - Sequence 111796 from Patent EP1572962.
KJ899834 - Synthetic construct Homo sapiens clone ccsbBroadEn_09228 TMEM25 gene, encodes complete protein.
BC036433 - Homo sapiens transmembrane protein 25, mRNA (cDNA clone IMAGE:4813899).
JD498042 - Sequence 479066 from Patent EP1572962.
JD276468 - Sequence 257492 from Patent EP1572962.
JD287425 - Sequence 268449 from Patent EP1572962.
JD499837 - Sequence 480861 from Patent EP1572962.
JD246822 - Sequence 227846 from Patent EP1572962.
JD246824 - Sequence 227848 from Patent EP1572962.
JD246825 - Sequence 227849 from Patent EP1572962.
JD246837 - Sequence 227861 from Patent EP1572962.
JD498428 - Sequence 479452 from Patent EP1572962.
JD220807 - Sequence 201831 from Patent EP1572962.
JD472703 - Sequence 453727 from Patent EP1572962.
JD466629 - Sequence 447653 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8J4, B0YJA6, B0YJA7, B0YJA9, NM_001144037, Q6UW89, Q86UA7, Q86YD3, Q96KA6, Q96MW9, TMM25_HUMAN, uc001ptl.1, uc001ptl.2, uc001ptl.3, UNQ2531/PRO6030
UCSC ID: uc001ptl.3
RefSeq Accession: NM_001144037
Protein: Q86YD3 (aka TMM25_HUMAN)
CCDS: CCDS44745.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.