Human Gene MSTO1 (ENST00000368341.8) from GENCODE V38
  Description: Homo sapiens misato mitochondrial distribution and morphology regulator 1 (MSTO1), transcript variant 25, mRNA. (from RefSeq NM_001350789)
Gencode Transcript: ENST00000368341.8
Gencode Gene: ENSG00000125459.17
Transcript (Including UTRs)
   Position: hg38 chr1:155,610,241-155,614,935 Size: 4,695 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr1:155,610,249-155,614,273 Size: 4,025 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:155,610,241-155,614,935)mRNA (may differ from genome)Protein (524 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MSTO1_HUMAN
DESCRIPTION: RecName: Full=Protein misato homolog 1;
FUNCTION: Involved in the regulation of mitochondrial distribution and morphology.
SUBCELLULAR LOCATION: Mitochondrion outer membrane.
TISSUE SPECIFICITY: Present in all cell lines tested (at protein level). Widely expressed.
SIMILARITY: Belongs to the misato family.
SEQUENCE CAUTION: Sequence=AAM12424.1; Type=Frameshift; Positions=419;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.94 RPKM in Testis
Total median expression: 268.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -194.60662-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019605 - Misato_II_myosin-like
IPR003008 - Tubulin_FtsZ_GTPase

Pfam Domains:
PF10644 - Misato Segment II tubulin-like domain
PF00091 - Tubulin/FtsZ family, GTPase domain

ModBase Predicted Comparative 3D Structure on Q9BUK6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGD   SGD
Protein SequenceProtein Sequence   Protein Sequence
AlignmentAlignment   Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0007005 mitochondrion organization
GO:0048311 mitochondrion distribution

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  KJ894142 - Synthetic construct Homo sapiens clone ccsbBroadEn_03536 MSTO1 gene, encodes complete protein.
AK295146 - Homo sapiens cDNA FLJ53788 complete cds, highly similar to Homo sapiens misato homolog 1 (MSTO1), mRNA.
AK290610 - Homo sapiens cDNA FLJ75054 complete cds, highly similar to Homo sapiens misato homolog 1 (Drosophila), mRNA.
CR936872 - Homo sapiens mRNA; cDNA DKFZp686B1757 (from clone DKFZp686B1757).
BX537684 - Homo sapiens mRNA; cDNA DKFZp781N2140 (from clone DKFZp781N2140); complete cds.
BC002535 - Homo sapiens misato homolog 1 (Drosophila), mRNA (cDNA clone MGC:959 IMAGE:3140498), complete cds.
AK001366 - Homo sapiens cDNA FLJ10504 fis, clone NT2RP2000438.
AK297140 - Homo sapiens cDNA FLJ54699 complete cds, highly similar to Homo sapiens misato homolog 1 (MSTO1), mRNA.
AK056128 - Homo sapiens cDNA FLJ31566 fis, clone NT2RI2001519, highly similar to Homo sapiens misato mRNA.
AK092950 - Homo sapiens cDNA FLJ35631 fis, clone SPLEN2011672, highly similar to Homo sapiens misato mRNA.
AX747823 - Sequence 1348 from Patent EP1308459.
CR749791 - Homo sapiens mRNA; cDNA DKFZp686I01261 (from clone DKFZp686I01261).
AK222863 - Homo sapiens mRNA for misato variant, clone: HEP13933.
CU678024 - Synthetic construct Homo sapiens gateway clone IMAGE:100017708 5' read MSTO1 mRNA.
AB587518 - Synthetic construct DNA, clone: pF1KE0027, Homo sapiens MSTO1 gene for misato homolog 1, without stop codon, in Flexi system.
AM393003 - Synthetic construct Homo sapiens clone IMAGE:100002434 for hypothetical protein (MSTO1 gene).
EU832296 - Synthetic construct Homo sapiens clone HAIB:100067325; DKFZo008B1127 misato homolog 1 (Drosophila) protein (MSTO1) gene, encodes complete protein.
EU832380 - Synthetic construct Homo sapiens clone HAIB:100067409; DKFZo004B1128 misato homolog 1 (Drosophila) protein (MSTO1) gene, encodes complete protein.
AK309573 - Homo sapiens cDNA, FLJ99614.
AF272833 - Homo sapiens misato mRNA, partial cds.
AY334564 - Homo sapiens misato mRNA, complete cds; alternatively spliced.
LF352138 - JP 2014500723-A/159641: Polycomb-Associated Non-Coding RNAs.
MA587715 - JP 2018138019-A/159641: Polycomb-Associated Non-Coding RNAs.
DQ574539 - Homo sapiens piRNA piR-42651, complete sequence.
LF352136 - JP 2014500723-A/159639: Polycomb-Associated Non-Coding RNAs.
MA587713 - JP 2018138019-A/159639: Polycomb-Associated Non-Coding RNAs.
JD094872 - Sequence 75896 from Patent EP1572962.
JD094873 - Sequence 75897 from Patent EP1572962.
JD052168 - Sequence 33192 from Patent EP1572962.
JD102204 - Sequence 83228 from Patent EP1572962.
JD303450 - Sequence 284474 from Patent EP1572962.
JD061639 - Sequence 42663 from Patent EP1572962.
DQ592951 - Homo sapiens piRNA piR-33063, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000368341.1, ENST00000368341.2, ENST00000368341.3, ENST00000368341.4, ENST00000368341.5, ENST00000368341.6, ENST00000368341.7, LST005, MSTO1_HUMAN, NM_001350789, Q53GR8, Q5CZ69, Q5T717, Q68CT6, Q7LBZ8, Q7Z3M7, Q7Z558, Q8TE05, Q9BUK6, Q9NQX2, Q9NVU4, SLTP005, uc057lqx.1
UCSC ID: ENST00000368341.8
RefSeq Accession: NM_018116
Protein: Q9BUK6 (aka MSTO1_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.