Human Gene RHBDL2 (ENST00000372990.6) Description and Page Index
Description: Homo sapiens rhomboid like 2 (RHBDL2), transcript variant 2, mRNA. (from RefSeq NM_017821) RefSeq Summary (NM_017821): The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]. Gencode Transcript: ENST00000372990.6 Gencode Gene: ENSG00000158315.11 Transcript (Including UTRs) Position: hg38 chr1:38,885,807-38,941,830 Size: 56,024 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr1:38,886,504-38,919,212 Size: 32,709 Coding Exon Count: 7
ID:RHBL2_HUMAN DESCRIPTION: RecName: Full=Rhomboid-related protein 2; Short=RRP2; EC=220.127.116.11; AltName: Full=Rhomboid-like protein 2; Contains: RecName: Full=Rhomboid-related protein 2, N-terminal fragment; Short=NTF; Contains: RecName: Full=Rhomboid-related protein 2, C-terminal fragment; Short=CTF; FUNCTION: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3. CATALYTIC ACTIVITY: Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains. SUBCELLULAR LOCATION: Rhomboid-related protein 2, C-terminal fragment: Cell membrane; Multi-pass membrane protein. PTM: Proteolytic processing of the proenzyme produces a N-terminal fragment (NTF) and a C-terminal fragment (CTF). The processing is required for activation of the protease. SIMILARITY: Belongs to the peptidase S54 family. SEQUENCE CAUTION: Sequence=AAH13103.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91168.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NX52
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.