Human Gene LRRC38 (ENST00000376085.4) from GENCODE V38
  Description: Homo sapiens leucine rich repeat containing 38 (LRRC38), mRNA. (from RefSeq NM_001010847)
Gencode Transcript: ENST00000376085.4
Gencode Gene: ENSG00000162494.6
Transcript (Including UTRs)
   Position: hg38 chr1:13,474,973-13,514,003 Size: 39,031 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr1:13,475,846-13,513,593 Size: 37,748 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:13,474,973-13,514,003)mRNA (may differ from genome)Protein (294 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: LRC38_HUMAN
DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 38; AltName: Full=BK channel auxilliary gamma subunit LRRC38; Flags: Precursor;
FUNCTION: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.
SUBUNIT: Interacts with KCNMA1.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Mainly expressed in adrenal gland, thymus and skeletal muscle.
DOMAIN: The transmembrane domain is necessary for interaction with KCNMA1 (By similarity).
SIMILARITY: Contains 5 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 LRRCT domain.
SIMILARITY: Contains 1 LRRNT domain.
SEQUENCE CAUTION: Sequence=AAH16048.1; Type=Frameshift; Positions=45;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.91 RPKM in Muscle - Skeletal
Total median expression: 35.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -165.00410-0.402 Picture PostScript Text
3' UTR -259.60873-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N

Pfam Domains:
PF01462 - Leucine rich repeat N-terminal domain

ModBase Predicted Comparative 3D Structure on Q5VT99
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005249 voltage-gated potassium channel activity
GO:0044325 ion channel binding
GO:0099104 potassium channel activator activity

Biological Process:
GO:0006811 ion transport
GO:0007409 axonogenesis
GO:0071805 potassium ion transmembrane transport
GO:1903818 positive regulation of voltage-gated potassium channel activity

Cellular Component:
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC016048 - Homo sapiens leucine rich repeat containing 38, mRNA (cDNA clone IMAGE:4645529), partial cds.
LP895739 - Sequence 603 from Patent EP3253886.
JD163367 - Sequence 144391 from Patent EP1572962.
JD163368 - Sequence 144392 from Patent EP1572962.
JD365409 - Sequence 346433 from Patent EP1572962.
JD252244 - Sequence 233268 from Patent EP1572962.
JD252243 - Sequence 233267 from Patent EP1572962.
JD169917 - Sequence 150941 from Patent EP1572962.
JD207358 - Sequence 188382 from Patent EP1572962.
JD358958 - Sequence 339982 from Patent EP1572962.
JD090889 - Sequence 71913 from Patent EP1572962.
JD232954 - Sequence 213978 from Patent EP1572962.
JD555499 - Sequence 536523 from Patent EP1572962.
JD261091 - Sequence 242115 from Patent EP1572962.
JD120106 - Sequence 101130 from Patent EP1572962.
JD123788 - Sequence 104812 from Patent EP1572962.
JD047227 - Sequence 28251 from Patent EP1572962.
JD448600 - Sequence 429624 from Patent EP1572962.
JD267632 - Sequence 248656 from Patent EP1572962.
JD224166 - Sequence 205190 from Patent EP1572962.
JD391108 - Sequence 372132 from Patent EP1572962.
JD398045 - Sequence 379069 from Patent EP1572962.
JD398451 - Sequence 379475 from Patent EP1572962.
JD174640 - Sequence 155664 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000376085.1, ENST00000376085.2, ENST00000376085.3, LRC38_HUMAN, NM_001010847, Q5VT99, Q96B32, uc001avb.1, uc001avb.2, uc001avb.3, uc001avb.4, uc001avb.5
UCSC ID: ENST00000376085.4
RefSeq Accession: NM_001010847
Protein: Q5VT99 (aka LRC38_HUMAN)
CCDS: CCDS53269.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.