Human Gene LRRC38 (ENST00000376085.4) from GENCODE V38
  Description: Homo sapiens leucine rich repeat containing 38 (LRRC38), mRNA. (from RefSeq NM_001010847)
Gencode Transcript: ENST00000376085.4
Gencode Gene: ENSG00000162494.6
Transcript (Including UTRs)
   Position: hg38 chr1:13,474,973-13,514,003 Size: 39,031 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr1:13,475,846-13,513,593 Size: 37,748 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:13,474,973-13,514,003)mRNA (may differ from genome)Protein (294 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 38; AltName: Full=BK channel auxilliary gamma subunit LRRC38; Flags: Precursor;
FUNCTION: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.
SUBUNIT: Interacts with KCNMA1.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Mainly expressed in adrenal gland, thymus and skeletal muscle.
DOMAIN: The transmembrane domain is necessary for interaction with KCNMA1 (By similarity).
SIMILARITY: Contains 5 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 LRRCT domain.
SIMILARITY: Contains 1 LRRNT domain.
SEQUENCE CAUTION: Sequence=AAH16048.1; Type=Frameshift; Positions=45;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.91 RPKM in Muscle - Skeletal
Total median expression: 35.43 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -165.00410-0.402 Picture PostScript Text
3' UTR -259.60873-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N

Pfam Domains:
PF01462 - Leucine rich repeat N-terminal domain

ModBase Predicted Comparative 3D Structure on Q5VT99
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005249 voltage-gated potassium channel activity
GO:0044325 ion channel binding
GO:0099104 potassium channel activator activity

Biological Process:
GO:0006811 ion transport
GO:0007409 axonogenesis
GO:0071805 potassium ion transmembrane transport
GO:1903818 positive regulation of voltage-gated potassium channel activity

Cellular Component:
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC016048 - Homo sapiens leucine rich repeat containing 38, mRNA (cDNA clone IMAGE:4645529), partial cds.
LP895739 - Sequence 603 from Patent EP3253886.
JD163367 - Sequence 144391 from Patent EP1572962.
JD163368 - Sequence 144392 from Patent EP1572962.
JD365409 - Sequence 346433 from Patent EP1572962.
JD252244 - Sequence 233268 from Patent EP1572962.
JD252243 - Sequence 233267 from Patent EP1572962.
JD169917 - Sequence 150941 from Patent EP1572962.
JD207358 - Sequence 188382 from Patent EP1572962.
JD358958 - Sequence 339982 from Patent EP1572962.
JD090889 - Sequence 71913 from Patent EP1572962.
JD232954 - Sequence 213978 from Patent EP1572962.
JD555499 - Sequence 536523 from Patent EP1572962.
JD261091 - Sequence 242115 from Patent EP1572962.
JD120106 - Sequence 101130 from Patent EP1572962.
JD123788 - Sequence 104812 from Patent EP1572962.
JD047227 - Sequence 28251 from Patent EP1572962.
JD448600 - Sequence 429624 from Patent EP1572962.
JD267632 - Sequence 248656 from Patent EP1572962.
JD224166 - Sequence 205190 from Patent EP1572962.
JD391108 - Sequence 372132 from Patent EP1572962.
JD398045 - Sequence 379069 from Patent EP1572962.
JD398451 - Sequence 379475 from Patent EP1572962.
JD174640 - Sequence 155664 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000376085.1, ENST00000376085.2, ENST00000376085.3, LRC38_HUMAN, NM_001010847, Q5VT99, Q96B32, uc001avb.1, uc001avb.2, uc001avb.3, uc001avb.4, uc001avb.5
UCSC ID: ENST00000376085.4
RefSeq Accession: NM_001010847
Protein: Q5VT99 (aka LRC38_HUMAN)
CCDS: CCDS53269.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.