Human Gene FBXO44 (ENST00000376760.5) Description and Page Index
Description: Homo sapiens F-box protein 44 (FBXO44), transcript variant 5, mRNA. (from RefSeq NM_001304790) RefSeq Summary (NM_001304790): This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]. Gencode Transcript: ENST00000376760.5 Gencode Gene: ENSG00000132879.14 Transcript (Including UTRs) Position: hg38 chr1:11,654,910-11,661,349 Size: 6,440 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr1:11,655,836-11,661,305 Size: 5,470 Coding Exon Count: 4
ID:FBX44_HUMAN DESCRIPTION: RecName: Full=F-box only protein 44; AltName: Full=F-box protein FBX30; AltName: Full=F-box/G-domain protein 3; FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1. TISSUE SPECIFICITY: Abundantly expressed in brain and kidney. Expressed at lower levels in heart, spleen and liver. MISCELLANEOUS: In contrast to other FBA domain containing proteins, FBXO44 demonstrates no significant binding to any of the 200 glycans tested. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 1 FBA (F-box associated) domain. SEQUENCE CAUTION: Sequence=CAI20210.1; Type=Erroneous gene model prediction; Sequence=CAI20213.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=FLAG-FBG3; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Fusion_411";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H4M3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK055344 - Homo sapiens cDNA FLJ30782 fis, clone FEBRA2000877, highly similar to Homo sapiens F-box protein 44 (FBXO44), transcript variant 3, mRNA. CR749368 - Homo sapiens mRNA; cDNA DKFZp781J0852 (from clone DKFZp781J0852). AK296025 - Homo sapiens cDNA FLJ59699 complete cds, highly similar to F-box only protein 44. AK301418 - Homo sapiens cDNA FLJ50713 complete cds, highly similar to F-box only protein 44. AK316284 - Homo sapiens cDNA, FLJ79183 complete cds, highly similar to F-box only protein 44. AK316347 - Homo sapiens cDNA, FLJ79246 complete cds, highly similar to F-box only protein 44. AY040878 - Homo sapiens F-box protein FBG3 (FBG3) mRNA, complete cds. AK293721 - Homo sapiens cDNA FLJ50458 complete cds, highly similar to Homo sapiens F-box protein 44 (FBXO44), transcript variant 3, mRNA. BC007832 - Homo sapiens F-box protein 44, mRNA (cDNA clone MGC:14140 IMAGE:4054414), complete cds. JD141850 - Sequence 122874 from Patent EP1572962. AK294053 - Homo sapiens cDNA FLJ59830 complete cds, highly similar to F-box only protein 44. AY007380 - Homo sapiens F-box protein FBX30 mRNA, complete cds. JD340415 - Sequence 321439 from Patent EP1572962. AB529198 - Synthetic construct DNA, clone: pF1KB5422, Homo sapiens FBXO44 gene for F-box protein 44, without stop codon, in Flexi system. CU675817 - Synthetic construct Homo sapiens gateway clone IMAGE:100023329 5' read FBXO44 mRNA. HQ448180 - Synthetic construct Homo sapiens clone IMAGE:100071574; CCSB005137_03 F-box protein 44 (FBXO44) gene, encodes complete protein. KJ895210 - Synthetic construct Homo sapiens clone ccsbBroadEn_04604 FBXO44 gene, encodes complete protein.