Human Gene FBXO44 (ENST00000376760.5) Description and Page Index
  Description: Homo sapiens F-box protein 44 (FBXO44), transcript variant 5, mRNA. (from RefSeq NM_001304790)
RefSeq Summary (NM_001304790): This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015].
Gencode Transcript: ENST00000376760.5
Gencode Gene: ENSG00000132879.14
Transcript (Including UTRs)
   Position: hg38 chr1:11,654,910-11,661,349 Size: 6,440 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr1:11,655,836-11,661,305 Size: 5,470 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:11,654,910-11,661,349)mRNA (may differ from genome)Protein (224 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FBX44_HUMAN
DESCRIPTION: RecName: Full=F-box only protein 44; AltName: Full=F-box protein FBX30; AltName: Full=F-box/G-domain protein 3;
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.
SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
TISSUE SPECIFICITY: Abundantly expressed in brain and kidney. Expressed at lower levels in heart, spleen and liver.
MISCELLANEOUS: In contrast to other FBA domain containing proteins, FBXO44 demonstrates no significant binding to any of the 200 glycans tested.
SIMILARITY: Contains 1 F-box domain.
SIMILARITY: Contains 1 FBA (F-box associated) domain.
SEQUENCE CAUTION: Sequence=CAI20210.1; Type=Erroneous gene model prediction; Sequence=CAI20213.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=FLAG-FBG3; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Fusion_411";

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 132.01 RPKM in Brain - Cerebellum
Total median expression: 1344.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.10103-0.438 Picture PostScript Text
3' UTR -4.2044-0.095 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007397 - F-box-assoc_dom
IPR001810 - F-box_dom_cyclin-like
IPR008979 - Galactose-bd-like

Pfam Domains:
PF04300 - F-box associated region

ModBase Predicted Comparative 3D Structure on Q9H4M3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding

Biological Process:
GO:0000209 protein polyubiquitination
GO:0010498 proteasomal protein catabolic process
GO:0043687 post-translational protein modification

Cellular Component:
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex


-  Descriptions from all associated GenBank mRNAs
  AK055344 - Homo sapiens cDNA FLJ30782 fis, clone FEBRA2000877, highly similar to Homo sapiens F-box protein 44 (FBXO44), transcript variant 3, mRNA.
CR749368 - Homo sapiens mRNA; cDNA DKFZp781J0852 (from clone DKFZp781J0852).
AK296025 - Homo sapiens cDNA FLJ59699 complete cds, highly similar to F-box only protein 44.
AK301418 - Homo sapiens cDNA FLJ50713 complete cds, highly similar to F-box only protein 44.
AK316284 - Homo sapiens cDNA, FLJ79183 complete cds, highly similar to F-box only protein 44.
AK316347 - Homo sapiens cDNA, FLJ79246 complete cds, highly similar to F-box only protein 44.
AY040878 - Homo sapiens F-box protein FBG3 (FBG3) mRNA, complete cds.
AK293721 - Homo sapiens cDNA FLJ50458 complete cds, highly similar to Homo sapiens F-box protein 44 (FBXO44), transcript variant 3, mRNA.
BC007832 - Homo sapiens F-box protein 44, mRNA (cDNA clone MGC:14140 IMAGE:4054414), complete cds.
JD141850 - Sequence 122874 from Patent EP1572962.
AK294053 - Homo sapiens cDNA FLJ59830 complete cds, highly similar to F-box only protein 44.
AY007380 - Homo sapiens F-box protein FBX30 mRNA, complete cds.
JD340415 - Sequence 321439 from Patent EP1572962.
AB529198 - Synthetic construct DNA, clone: pF1KB5422, Homo sapiens FBXO44 gene for F-box protein 44, without stop codon, in Flexi system.
CU675817 - Synthetic construct Homo sapiens gateway clone IMAGE:100023329 5' read FBXO44 mRNA.
HQ448180 - Synthetic construct Homo sapiens clone IMAGE:100071574; CCSB005137_03 F-box protein 44 (FBXO44) gene, encodes complete protein.
KJ895210 - Synthetic construct Homo sapiens clone ccsbBroadEn_04604 FBXO44 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H4M3 (Reactome details) participates in the following event(s):

R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex
R-HSA-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex
R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases
R-HSA-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex
R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-8951664 Neddylation
R-HSA-1280218 Adaptive Immune System
R-HSA-597592 Post-translational protein modification
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B3KNZ2, B7Z743, FBG3, FBX30, FBX44, FBX44_HUMAN, FBX6A, FBXO6A, NM_001304790, Q5TGX2, Q5TGX4, Q5TGX5, Q68DJ9, Q8WWY2, Q9H4M3, uc057cgm.1
UCSC ID: uc057cgm.1
RefSeq Accession: NM_001304790
Protein: Q9H4M3 (aka FBX44_HUMAN or FX44_HUMAN)
CCDS: CCDS131.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.