Human Gene THAP3 (ENST00000377627.7) from GENCODE V44
  Description: Homo sapiens THAP domain containing 3 (THAP3), transcript variant 2, mRNA. (from RefSeq NM_138350)
Gencode Transcript: ENST00000377627.7
Gencode Gene: ENSG00000041988.16
Transcript (Including UTRs)
   Position: hg38 chr1:6,625,192-6,635,586 Size: 10,395 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr1:6,625,219-6,634,088 Size: 8,870 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:6,625,192-6,635,586)mRNA (may differ from genome)Protein (175 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=THAP domain-containing protein 3;
FUNCTION: Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.
SUBUNIT: Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM).
TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.
SIMILARITY: Contains 1 THAP-type zinc finger.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.76 RPKM in Uterus
Total median expression: 312.19 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3027-0.270 Picture PostScript Text
3' UTR -647.801498-0.432 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026520 - THAP3
IPR006612 - Znf_C2CH

Pfam Domains:
PF05485 - THAP domain

ModBase Predicted Comparative 3D Structure on Q8WTV1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter

-  Descriptions from all associated GenBank mRNAs
  BC092427 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone MGC:102992 IMAGE:30376814), complete cds.
AK096217 - Homo sapiens cDNA FLJ38898 fis, clone NT2NE2000374.
BC022081 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone IMAGE:4813302), with apparent retained intron.
DQ891670 - Synthetic construct clone IMAGE:100004300; FLH179145.01X; RZPDo839D04130D THAP domain containing, apoptosis associated protein 3 (THAP3) gene, encodes complete protein.
DQ894856 - Synthetic construct Homo sapiens clone IMAGE:100009316; FLH179141.01L; RZPDo839D04129D THAP domain containing, apoptosis associated protein 3 (THAP3) gene, encodes complete protein.
BC005114 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone IMAGE:4053044), partial cds.
JD021074 - Sequence 2098 from Patent EP1572962.
JD034296 - Sequence 15320 from Patent EP1572962.
AF086370 - Homo sapiens full length insert cDNA clone ZD67D08.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000377627.1, ENST00000377627.2, ENST00000377627.3, ENST00000377627.4, ENST00000377627.5, ENST00000377627.6, NM_138350, Q569K1, Q5TH66, Q5TH67, Q8N8T6, Q8WTV1, Q9BSC7, Q9Y3H2, Q9Y3H3, THAP3_HUMAN, uc001aoe.1, uc001aoe.2, uc001aoe.3
UCSC ID: ENST00000377627.7
RefSeq Accession: NM_138350
Protein: Q8WTV1 (aka THAP3_HUMAN or THA3_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.