ID:THAP3_HUMAN DESCRIPTION: RecName: Full=THAP domain-containing protein 3; FUNCTION: Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. SUBUNIT: Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM). TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver. SIMILARITY: Contains 1 THAP-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WTV1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0046872 metal ion binding
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter
Descriptions from all associated GenBank mRNAs
BC092427 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone MGC:102992 IMAGE:30376814), complete cds. AK096217 - Homo sapiens cDNA FLJ38898 fis, clone NT2NE2000374. BC022081 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone IMAGE:4813302), with apparent retained intron. DQ891670 - Synthetic construct clone IMAGE:100004300; FLH179145.01X; RZPDo839D04130D THAP domain containing, apoptosis associated protein 3 (THAP3) gene, encodes complete protein. DQ894856 - Synthetic construct Homo sapiens clone IMAGE:100009316; FLH179141.01L; RZPDo839D04129D THAP domain containing, apoptosis associated protein 3 (THAP3) gene, encodes complete protein. BC005114 - Homo sapiens THAP domain containing, apoptosis associated protein 3, mRNA (cDNA clone IMAGE:4053044), partial cds. JD021074 - Sequence 2098 from Patent EP1572962. JD034296 - Sequence 15320 from Patent EP1572962. AF086370 - Homo sapiens full length insert cDNA clone ZD67D08.
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