Human Gene RNF207 (ENST00000377939.5) from GENCODE V44
  Description: Homo sapiens ring finger protein 207 (RNF207), mRNA. (from RefSeq NM_207396)
Gencode Transcript: ENST00000377939.5
Gencode Gene: ENSG00000158286.13
Transcript (Including UTRs)
   Position: hg38 chr1:6,206,119-6,221,299 Size: 15,181 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg38 chr1:6,206,536-6,219,407 Size: 12,872 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:6,206,119-6,221,299)mRNA (may differ from genome)Protein (634 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=RING finger protein 207;
POLYMORPHISM: Genetic variation in RNF207 may influence the duration of QT interval, a mesure of cardiac repolarization that depends on multiple environmental and genetic contributors. Prolonged or shortened QT intervals predisposes to ventricular arrhythmias and are a risk factor for sudden cardiac death.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=AAI28238.1; Type=Erroneous initiation;

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.07 RPKM in Heart - Left Ventricle
Total median expression: 195.85 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.10184-0.452 Picture PostScript Text
3' UTR -600.001892-0.317 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000315 - Znf_B-box
IPR018957 - Znf_C3HC4_RING-type
IPR001841 - Znf_RING
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00643 - B-box zinc finger
PF00097 - Zinc finger, C3HC4 type (RING finger)

ModBase Predicted Comparative 3D Structure on Q6ZRF8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030544 Hsp70 protein binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
GO:0051087 chaperone binding

Biological Process:
GO:0010628 positive regulation of gene expression
GO:0055117 regulation of cardiac muscle contraction
GO:0086019 cell-cell signaling involved in cardiac conduction
GO:1901207 regulation of heart looping
GO:1902261 positive regulation of delayed rectifier potassium channel activity
GO:1903762 positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1903954 positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm

-  Descriptions from all associated GenBank mRNAs
  AK128246 - Homo sapiens cDNA FLJ46380 fis, clone THYMU2008207.
BC119780 - Homo sapiens ring finger protein 207, mRNA (cDNA clone IMAGE:40109293), complete cds.
BC034459 - Homo sapiens ring finger protein 207, mRNA (cDNA clone IMAGE:5185460).
AK056658 - Homo sapiens cDNA FLJ32096 fis, clone OCBBF2001075.
AK294223 - Homo sapiens cDNA FLJ54599 complete cds.
JD460641 - Sequence 441665 from Patent EP1572962.
BC128237 - Homo sapiens ring finger protein 207, mRNA (cDNA clone IMAGE:40114681), partial cds.
JD523468 - Sequence 504492 from Patent EP1572962.
JD272458 - Sequence 253482 from Patent EP1572962.
AK127700 - Homo sapiens cDNA FLJ45800 fis, clone NT2RI2028537.
JD162307 - Sequence 143331 from Patent EP1572962.
JD443572 - Sequence 424596 from Patent EP1572962.
JD254990 - Sequence 236014 from Patent EP1572962.
JD290004 - Sequence 271028 from Patent EP1572962.
JD130387 - Sequence 111411 from Patent EP1572962.
JD439005 - Sequence 420029 from Patent EP1572962.
JD053986 - Sequence 35010 from Patent EP1572962.
AK128450 - Homo sapiens cDNA FLJ46593 fis, clone THYMU3045673.
JD248210 - Sequence 229234 from Patent EP1572962.
JD056669 - Sequence 37693 from Patent EP1572962.
JD476570 - Sequence 457594 from Patent EP1572962.
JD046912 - Sequence 27936 from Patent EP1572962.
JD477983 - Sequence 459007 from Patent EP1572962.
JD289195 - Sequence 270219 from Patent EP1572962.
JD153654 - Sequence 134678 from Patent EP1572962.
JD428381 - Sequence 409405 from Patent EP1572962.
JD293420 - Sequence 274444 from Patent EP1572962.
JD364355 - Sequence 345379 from Patent EP1572962.
JD108003 - Sequence 89027 from Patent EP1572962.
JD342100 - Sequence 323124 from Patent EP1572962.
JD311729 - Sequence 292753 from Patent EP1572962.
JD124511 - Sequence 105535 from Patent EP1572962.
JD072290 - Sequence 53314 from Patent EP1572962.
JD505489 - Sequence 486513 from Patent EP1572962.
JD046346 - Sequence 27370 from Patent EP1572962.
JD064305 - Sequence 45329 from Patent EP1572962.
JD341998 - Sequence 323022 from Patent EP1572962.
JD305403 - Sequence 286427 from Patent EP1572962.
JD313773 - Sequence 294797 from Patent EP1572962.
JD356514 - Sequence 337538 from Patent EP1572962.
JD415651 - Sequence 396675 from Patent EP1572962.
JD111113 - Sequence 92137 from Patent EP1572962.
JD180839 - Sequence 161863 from Patent EP1572962.
JD040297 - Sequence 21321 from Patent EP1572962.
JD464640 - Sequence 445664 from Patent EP1572962.
JD252358 - Sequence 233382 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2VCM8, B4DFR6, C1orf188, ENST00000377939.1, ENST00000377939.2, ENST00000377939.3, ENST00000377939.4, NM_207396, Q5TGS6, Q6ZRF8, Q6ZS63, Q96MP2, RN207_HUMAN, uc001amg.1, uc001amg.2, uc001amg.3, uc001amg.4, uc001amg.5
UCSC ID: ENST00000377939.5
RefSeq Accession: NM_207396
Protein: Q6ZRF8 (aka RN207_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.