Human Gene SEC61A2 (ENST00000379020.8) Description and Page Index
Description: Membrane; Multi-pass membrane protein (By similarity). (from UniProt F8W776) RefSeq Summary (NM_018144): The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]. Gencode Transcript: ENST00000379020.8 Gencode Gene: ENSG00000065665.21 Transcript (Including UTRs) Position: hg38 chr10:12,129,727-12,165,412 Size: 35,686 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr10:12,129,788-12,164,454 Size: 34,667 Coding Exon Count: 11
ID:F8W776_HUMAN DESCRIPTION: SubName: Full=Protein transport protein Sec61 subunit alpha isoform 2; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the SecY/SEC61-alpha family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on F8W776
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB046850 - Homo sapiens mRNA for KIAA1630 protein, partial cds. AK301841 - Homo sapiens cDNA FLJ61445 complete cds, highly similar to Protein transport protein Sec61 subunit alpha isoform 2. AK292295 - Homo sapiens cDNA FLJ77369 complete cds, highly similar to Homo sapiens Sec61 alpha 2 subunit (SEC61A2), mRNA. BC026179 - Homo sapiens Sec61 alpha 2 subunit (S. cerevisiae), mRNA (cDNA clone MGC:32910 IMAGE:4823130), complete cds. AF346603 - Homo sapiens Sec61 alpha form 2 mRNA, complete cds. AK057532 - Homo sapiens cDNA FLJ32970 fis, clone TESTI2008840, highly similar to Protein transport protein Sec61 subunit alpha isoform 2. AK022640 - Homo sapiens cDNA FLJ12578 fis, clone NT2RM4001054, moderately similar to Homo sapiens sec61 homolog mRNA. JD458112 - Sequence 439136 from Patent EP1572962. JF432518 - Synthetic construct Homo sapiens clone IMAGE:100073740 Sec61 alpha 2 subunit (S. cerevisiae) (SEC61A2) gene, encodes complete protein. KJ902782 - Synthetic construct Homo sapiens clone ccsbBroadEn_12176 SEC61A2 gene, encodes complete protein. AK022027 - Homo sapiens cDNA FLJ11965 fis, clone HEMBB1001112, moderately similar to Homo sapiens sec61 homolog mRNA. AK001440 - Homo sapiens cDNA FLJ10578 fis, clone NT2RP2003433, highly similar to PROTEIN TRANSPORT PROTEIN SEC61 ALPHA SUBUNIT. JD304713 - Sequence 285737 from Patent EP1572962. JD085048 - Sequence 66072 from Patent EP1572962. JD410034 - Sequence 391058 from Patent EP1572962. JD564887 - Sequence 545911 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03060 - Protein export hsa05110 - Vibrio cholerae infection