Human Gene B3GALT5 (ENST00000380620.8) from GENCODE V38
  Description: Homo sapiens beta-1,3-galactosyltransferase 5 (B3GALT5), transcript variant 4, mRNA. (from RefSeq NM_033172)
RefSeq Summary (NM_001356338): This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017].
Gencode Transcript: ENST00000380620.8
Gencode Gene: ENSG00000183778.18
Transcript (Including UTRs)
   Position: hg38 chr21:39,556,442-39,673,137 Size: 116,696 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr21:39,660,560-39,661,492 Size: 933 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:39,556,442-39,673,137)mRNA (may differ from genome)Protein (310 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtOMIMPubMedUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: B3GT5_HUMAN
DESCRIPTION: RecName: Full=Beta-1,3-galactosyltransferase 5; Short=Beta-1,3-GalTase 5; Short=Beta3Gal-T5; Short=Beta3GalT5; Short=b3Gal-T5; EC=2.4.1.-; AltName: Full=Beta-3-Gx-T5; AltName: Full=UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5; AltName: Full=UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5;
FUNCTION: Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.
PATHWAY: Protein modification; protein glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.
SIMILARITY: Belongs to the glycosyltransferase 31 family.
WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT5";
WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=Beta-1,3-galactosyltransferase 5; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_432";

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.66 RPKM in Small Intestine - Terminal Ileum
Total median expression: 32.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -169.70592-0.287 Picture PostScript Text
3' UTR -3783.4011645-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002659 - Glyco_trans_31

Pfam Domains:
PF01762 - Galactosyltransferase

ModBase Predicted Comparative 3D Structure on Q9Y2C3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008378 galactosyltransferase activity
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups

Biological Process:
GO:0006486 protein glycosylation

Cellular Component:
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY372061 - Homo sapiens beta-1,3-galactosyltransferase 5 (B3GALT5) mRNA, complete cds.
AK292951 - Homo sapiens cDNA FLJ75982 complete cds, highly similar to Homo sapiens UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3GALT5), transcript variant 1, mRNA.
DQ645732 - Homo sapiens beta-1,3-galactosyltransferase beta3Gal-T5 mRNA, 5' UTR type A long variant, alternatively spliced.
DQ645733 - Homo sapiens beta-1,3-galactosyltransferase beta3Gal-T5 mRNA, 5' UTR type A short variant, alternatively spliced.
DQ645734 - Homo sapiens beta-1,3-galactosyltransferase beta3Gal-T5 mRNA, 5' UTR type A longest variant, alternatively spliced.
DQ645735 - Homo sapiens beta-1,3-galactosyltransferase beta3Gal-T5 mRNA, 5' UTR type B long variant, alternatively spliced.
DQ645736 - Homo sapiensbeta-1,3-galactosyltransferase beta3Gal-T5 mRNA, 5' UTR type B short variant, alternatively spliced.
DQ645737 - Homo sapiens beta-1,3-galactosyltransferase beta3Gal-T5 mRNA, 5' UTR type C long variant, alternatively spliced.
DQ645738 - Homo sapiens beta-1,3-galactosyltransferase beta3Gal-T5 mRNA, 5' UTR type C short variant, alternatively spliced.
AB020337 - Homo sapiens mRNA for UDP-Gal:GlcNAc beta1,3-galactosyltransferase 5, complete cds.
JD501058 - Sequence 482082 from Patent EP1572962.
BC104862 - Homo sapiens UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5, mRNA (cDNA clone MGC:132522 IMAGE:8143865), complete cds.
BC104864 - Homo sapiens UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5, mRNA (cDNA clone MGC:132524 IMAGE:8143867), complete cds.
KJ898192 - Synthetic construct Homo sapiens clone ccsbBroadEn_07586 B3GALT5 gene, encodes complete protein.
JD387060 - Sequence 368084 from Patent EP1572962.
JD354807 - Sequence 335831 from Patent EP1572962.
JD165684 - Sequence 146708 from Patent EP1572962.
JD438489 - Sequence 419513 from Patent EP1572962.
JD285383 - Sequence 266407 from Patent EP1572962.
JD139228 - Sequence 120252 from Patent EP1572962.
JD287320 - Sequence 268344 from Patent EP1572962.
JD076946 - Sequence 57970 from Patent EP1572962.
JD182958 - Sequence 163982 from Patent EP1572962.
JD203110 - Sequence 184134 from Patent EP1572962.
JD226474 - Sequence 207498 from Patent EP1572962.
JD124654 - Sequence 105678 from Patent EP1572962.
JD463358 - Sequence 444382 from Patent EP1572962.
JD328265 - Sequence 309289 from Patent EP1572962.
JD381600 - Sequence 362624 from Patent EP1572962.
JD367773 - Sequence 348797 from Patent EP1572962.
JD157273 - Sequence 138297 from Patent EP1572962.
JD482473 - Sequence 463497 from Patent EP1572962.
JD361459 - Sequence 342483 from Patent EP1572962.
JD042241 - Sequence 23265 from Patent EP1572962.
JD506657 - Sequence 487681 from Patent EP1572962.
DQ594219 - Homo sapiens piRNA piR-60331, complete sequence.
JD022927 - Sequence 3951 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00601 - Glycosphingolipid biosynthesis - lacto and neolacto series
hsa00603 - Glycosphingolipid biosynthesis - globo series
hsa01100 - Metabolic pathways

BioCyc Knowledge Library
PWY-7832 - ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide
PWY-7835 - superpathway of glycosphingolipids biosynthesis
PWY-7838 - globo-series glycosphingolipids biosynthesis
PWY-7839 - lacto-series glycosphingolipids biosynthesis

-  Other Names for This Gene
  Alternate Gene Symbols: A8KA86, B3GT5_HUMAN, D3DSI3, ENST00000380620.1, ENST00000380620.2, ENST00000380620.3, ENST00000380620.4, ENST00000380620.5, ENST00000380620.6, ENST00000380620.7, NM_033172, Q2M3L5, Q53Z19, Q9NY96, Q9P1X6, Q9P1X7, Q9Y2C3, uc002yyb.1, uc002yyb.2, uc002yyb.3
UCSC ID: ENST00000380620.8
RefSeq Accession: NM_001356338
Protein: Q9Y2C3 (aka B3GT5_HUMAN or B3G5_HUMAN)
CCDS: CCDS13667.1, CCDS74795.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.