Human Gene VEPH1 (ENST00000392833.6) Description and Page Index
  Description: Homo sapiens ventricular zone expressed PH domain containing 1 (VEPH1), transcript variant 3, mRNA. (from RefSeq NM_001167911)
Gencode Transcript: ENST00000392833.6
Gencode Gene: ENSG00000197415.12
Transcript (Including UTRs)
   Position: hg38 chr3:157,259,742-157,503,339 Size: 243,598 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg38 chr3:157,261,134-157,495,349 Size: 234,216 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:157,259,742-157,503,339)mRNA (may differ from genome)Protein (788 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: MELT_HUMAN
DESCRIPTION: RecName: Full=Ventricular zone-expressed PH domain-containing protein homolog 1; AltName: Full=Protein melted;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
DOMAIN: The PH domain is required for membrane targeting (By similarity).
SIMILARITY: Belongs to the MELT/VEPH family.
SIMILARITY: Contains 1 PH domain.
SEQUENCE CAUTION: Sequence=BAB14165.1; Type=Erroneous initiation; Sequence=BAB21783.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.79 RPKM in Pituitary
Total median expression: 34.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.30220-0.206 Picture PostScript Text
3' UTR -284.501392-0.204 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00169 - PH domain

ModBase Predicted Comparative 3D Structure on Q14D04
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AL713656 - Homo sapiens mRNA; cDNA DKFZp547E1615 (from clone DKFZp547E1615).
BC111017 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone MGC:111426 IMAGE:5174889), complete cds.
AK022666 - Homo sapiens cDNA FLJ12604 fis, clone NT2RM4001454.
AB051479 - Homo sapiens KIAA1692 mRNA for KIAA1692 protein.
BC026235 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone IMAGE:4253208).
AK027625 - Homo sapiens cDNA FLJ14719 fis, clone NT2RP3001457, weakly similar to Drosophila melanogaster Melted (melt) mRNA.
BC042159 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone IMAGE:4871731), partial cds.
BC101660 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone MGC:126709 IMAGE:8069166), complete cds.
BC113555 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone MGC:142115 IMAGE:8322607), complete cds.
HQ258524 - Synthetic construct Homo sapiens clone IMAGE:100072953 ventricular zone expressed PH domain homolog 1 (zebrafish) (VEPH1), transcript variant 1 (VEPH1) gene, encodes complete protein.
KJ894712 - Synthetic construct Homo sapiens clone ccsbBroadEn_04106 VEPH1 gene, encodes complete protein.
AB384625 - Synthetic construct DNA, clone: pF1KA1692, Homo sapiens VEPH1 gene for ventricular zone expressed PH domain homolog 1, complete cds, without stop codon, in Flexi system.
JD527473 - Sequence 508497 from Patent EP1572962.
BC078142 - Homo sapiens cDNA clone IMAGE:5761541, partial cds.
BC057999 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone IMAGE:4610969), complete cds.
CU691278 - Synthetic construct Homo sapiens gateway clone IMAGE:100022980 5' read VEPH1 mRNA.
KJ906317 - Synthetic construct Homo sapiens clone ccsbBroadEn_15987 VEPH1 gene, encodes complete protein.
JD082636 - Sequence 63660 from Patent EP1572962.
JD355001 - Sequence 336025 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DNL0, KIAA1692, MELT_HUMAN, NM_001167911, Q14D04, Q2TAA9, Q3MIX2, Q6PEL3, Q86TL5, Q8TCR3, Q96SP7, Q9C0H1, Q9H9Q7, uc010hvu.1, uc010hvu.2, uc010hvu.3, VEPH
UCSC ID: uc010hvu.3
RefSeq Accession: NM_001167911
Protein: Q14D04 (aka MELT_HUMAN)
CCDS: CCDS54662.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.