Human Gene VEPH1 (ENST00000392833.6) Description and Page Index
Description: Homo sapiens ventricular zone expressed PH domain containing 1 (VEPH1), transcript variant 3, mRNA. (from RefSeq NM_001167911)
Gencode Transcript: ENST00000392833.6
Gencode Gene: ENSG00000197415.12
Transcript (Including UTRs)
Position: hg38 chr3:157,259,742-157,503,339 Size: 243,598 Total Exon Count: 13 Strand: -
Position: hg38 chr3:157,261,134-157,495,349 Size: 234,216 Coding Exon Count: 12
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ventricular zone-expressed PH domain-containing protein homolog 1; AltName: Full=Protein melted;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). DOMAIN: The PH domain is required for membrane targeting (By similarity). SIMILARITY: Belongs to the MELT/VEPH family. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=BAB14165.1; Type=Erroneous initiation; Sequence=BAB21783.1; Type=Erroneous initiation;
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
Pfam Domains: PF00169 - PH domain
ModBase Predicted Comparative 3D Structure on Q14D04
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AL713656 - Homo sapiens mRNA; cDNA DKFZp547E1615 (from clone DKFZp547E1615). BC111017 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone MGC:111426 IMAGE:5174889), complete cds. AK022666 - Homo sapiens cDNA FLJ12604 fis, clone NT2RM4001454. AB051479 - Homo sapiens KIAA1692 mRNA for KIAA1692 protein. BC026235 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone IMAGE:4253208). AK027625 - Homo sapiens cDNA FLJ14719 fis, clone NT2RP3001457, weakly similar to Drosophila melanogaster Melted (melt) mRNA. BC042159 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone IMAGE:4871731), partial cds. BC101660 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone MGC:126709 IMAGE:8069166), complete cds. BC113555 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone MGC:142115 IMAGE:8322607), complete cds. HQ258524 - Synthetic construct Homo sapiens clone IMAGE:100072953 ventricular zone expressed PH domain homolog 1 (zebrafish) (VEPH1), transcript variant 1 (VEPH1) gene, encodes complete protein. KJ894712 - Synthetic construct Homo sapiens clone ccsbBroadEn_04106 VEPH1 gene, encodes complete protein. AB384625 - Synthetic construct DNA, clone: pF1KA1692, Homo sapiens VEPH1 gene for ventricular zone expressed PH domain homolog 1, complete cds, without stop codon, in Flexi system. JD527473 - Sequence 508497 from Patent EP1572962. BC078142 - Homo sapiens cDNA clone IMAGE:5761541, partial cds. BC057999 - Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish), mRNA (cDNA clone IMAGE:4610969), complete cds. CU691278 - Synthetic construct Homo sapiens gateway clone IMAGE:100022980 5' read VEPH1 mRNA. KJ906317 - Synthetic construct Homo sapiens clone ccsbBroadEn_15987 VEPH1 gene, encodes complete protein. JD082636 - Sequence 63660 from Patent EP1572962. JD355001 - Sequence 336025 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: D3DNL0, KIAA1692, MELT_HUMAN, NM_001167911, Q14D04, Q2TAA9, Q3MIX2, Q6PEL3, Q86TL5, Q8TCR3, Q96SP7, Q9C0H1, Q9H9Q7, uc010hvu.1, uc010hvu.2, uc010hvu.3, VEPH UCSC ID: uc010hvu.3 RefSeq Accession: NM_001167911
(aka MELT_HUMAN) Q14D04
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.