Human Gene KIAA1191 (ENST00000393725.6) Description and Page Index
  Description: Homo sapiens KIAA1191 (KIAA1191), transcript variant 2, mRNA. (from RefSeq NM_001079684)
Gencode Transcript: ENST00000393725.6
Gencode Gene: ENSG00000122203.15
Transcript (Including UTRs)
   Position: hg38 chr5:176,346,062-176,361,765 Size: 15,704 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr5:176,347,600-176,355,720 Size: 8,121 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:176,346,062-176,361,765)mRNA (may differ from genome)Protein (286 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Putative monooxygenase p33MONOX; EC=1.-.-.-; AltName: Full=Brain-derived rescue factor p60MONOX; AltName: Full=Flavine monooxygenase motif-containing protein of 33 kDa;
FUNCTION: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.
SUBUNIT: Interacts with COBRA1, NOL12 and PRNP.
INTERACTION: P04156:PRNP; NbExp=1; IntAct=EBI-725897, EBI-977302;
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Down-regulated in the occipital lobe of an early stage Alzheimer's disease patients.
SIMILARITY: Belongs to the P33MONOX family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 49.82 RPKM in Kidney - Cortex
Total median expression: 1355.49 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.70301-0.321 Picture PostScript Text
3' UTR -458.411538-0.298 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026759 - P33MONOX

ModBase Predicted Comparative 3D Structure on Q96A73
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0016491 oxidoreductase activity

Biological Process:
GO:0008150 biological_process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005575 cellular_component
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  KJ894407 - Synthetic construct Homo sapiens clone ccsbBroadEn_03801 KIAA1191 gene, encodes complete protein.
BC006316 - Homo sapiens KIAA1191, mRNA (cDNA clone IMAGE:4125466), complete cds.
BC012848 - Homo sapiens KIAA1191, mRNA (cDNA clone IMAGE:3862538), complete cds.
BC017097 - Homo sapiens KIAA1191, mRNA (cDNA clone MGC:14952 IMAGE:3529175), complete cds.
AL390217 - Homo sapiens mRNA; cDNA DKFZp564M1982 (from clone DKFZp564M1982).
BX648859 - Homo sapiens mRNA; cDNA DKFZp686K02233 (from clone DKFZp686K02233).
AB033017 - Homo sapiens mRNA for KIAA1191 protein, partial cds.
AL832558 - Homo sapiens mRNA; cDNA DKFZp547D1018 (from clone DKFZp547D1018).
BC010448 - Homo sapiens KIAA1191, mRNA (cDNA clone MGC:18195 IMAGE:4155679), complete cds.
JD168710 - Sequence 149734 from Patent EP1572962.
JD299775 - Sequence 280799 from Patent EP1572962.
JD443841 - Sequence 424865 from Patent EP1572962.
JD508042 - Sequence 489066 from Patent EP1572962.
JD147008 - Sequence 128032 from Patent EP1572962.
JD341728 - Sequence 322752 from Patent EP1572962.
JD470547 - Sequence 451571 from Patent EP1572962.
JD544709 - Sequence 525733 from Patent EP1572962.
JD510183 - Sequence 491207 from Patent EP1572962.
JD060858 - Sequence 41882 from Patent EP1572962.
JD174741 - Sequence 155765 from Patent EP1572962.
JD449053 - Sequence 430077 from Patent EP1572962.
JD137088 - Sequence 118112 from Patent EP1572962.
JD410908 - Sequence 391932 from Patent EP1572962.
JD366478 - Sequence 347502 from Patent EP1572962.
JD249605 - Sequence 230629 from Patent EP1572962.
JD085132 - Sequence 66156 from Patent EP1572962.
JD447701 - Sequence 428725 from Patent EP1572962.
JD332027 - Sequence 313051 from Patent EP1572962.
JD175733 - Sequence 156757 from Patent EP1572962.
JD531482 - Sequence 512506 from Patent EP1572962.
JD444387 - Sequence 425411 from Patent EP1572962.
JD169175 - Sequence 150199 from Patent EP1572962.
JD193546 - Sequence 174570 from Patent EP1572962.
JD452672 - Sequence 433696 from Patent EP1572962.
JD204593 - Sequence 185617 from Patent EP1572962.
JD142887 - Sequence 123911 from Patent EP1572962.
JD065927 - Sequence 46951 from Patent EP1572962.
JD472388 - Sequence 453412 from Patent EP1572962.
JD472389 - Sequence 453413 from Patent EP1572962.
JD472390 - Sequence 453414 from Patent EP1572962.
JD188881 - Sequence 169905 from Patent EP1572962.
JD078398 - Sequence 59422 from Patent EP1572962.
JD101892 - Sequence 82916 from Patent EP1572962.
JD481269 - Sequence 462293 from Patent EP1572962.
AK024675 - Homo sapiens cDNA: FLJ21022 fis, clone CAE06383.
AK225073 - Homo sapiens mRNA for hypothetical protein LOC57179 variant, clone: CAE06383.
JD097533 - Sequence 78557 from Patent EP1572962.
DQ073392 - Homo sapiens p33MONOX mRNA, complete cds.
AK315428 - Homo sapiens cDNA, FLJ96484.
CU679717 - Synthetic construct Homo sapiens gateway clone IMAGE:100018797 5' read KIAA1191 mRNA.
HQ447415 - Synthetic construct Homo sapiens clone IMAGE:100070738; CCSB002447_04 KIAA1191 (KIAA1191) gene, encodes complete protein.
EU831935 - Synthetic construct Homo sapiens clone HAIB:100066964; DKFZo008C1223 KIAA1191 protein (KIAA1191) gene, encodes complete protein.
EU832030 - Synthetic construct Homo sapiens clone HAIB:100067059; DKFZo004C1224 KIAA1191 protein (KIAA1191) gene, encodes complete protein.
AB384580 - Synthetic construct DNA, clone: pF1KA1191, Homo sapiens KIAA1191 gene for KIAA1191 protein, complete cds, without stop codon, in Flexi system.
CR457331 - Homo sapiens full open reading frame cDNA clone RZPDo834F0413D for gene KIAA1191, KIAA1191 protein; complete cds, incl. stopcodon.
JD405069 - Sequence 386093 from Patent EP1572962.
JD201820 - Sequence 182844 from Patent EP1572962.
DQ577363 - Homo sapiens piRNA piR-45475, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RD69, B8K1S6, NM_001079684, P33MONOX, P33MX_HUMAN, Q6IA24, Q8NDU3, Q96A73, Q9BRE5, Q9H7D5, Q9ULM9, uc003mdx.1, uc003mdx.2, uc003mdx.3, uc003mdx.4, uc003mdx.5
UCSC ID: uc003mdx.5
RefSeq Accession: NM_001079684
Protein: Q96A73 (aka P33MX_HUMAN)
CCDS: CCDS43402.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.