Human Gene NFKB1 (ENST00000394820.8) Description and Page Index
  Description: Homo sapiens nuclear factor kappa B subunit 1 (NFKB1), transcript variant 2, mRNA. (from RefSeq NM_001165412)
RefSeq Summary (NM_001165412): This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016].
Gencode Transcript: ENST00000394820.8
Gencode Gene: ENSG00000109320.13
Transcript (Including UTRs)
   Position: hg38 chr4:102,501,331-102,616,915 Size: 115,585 Total Exon Count: 24 Strand: +
Coding Region
   Position: hg38 chr4:102,525,519-102,616,594 Size: 91,076 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:102,501,331-102,616,915)mRNA (may differ from genome)Protein (968 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: NFKB1_HUMAN
DESCRIPTION: RecName: Full=Nuclear factor NF-kappa-B p105 subunit; AltName: Full=DNA-binding factor KBF1; AltName: Full=EBP-1; AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Contains: RecName: Full=Nuclear factor NF-kappa-B p50 subunit;
FUNCTION: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
SUBUNIT: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF- kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1. Interacts with HIF1AN.
INTERACTION: Q92887:ABCC2; NbExp=3; IntAct=EBI-300010, EBI-3916193; P03372:ESR1; NbExp=3; IntAct=EBI-697771, EBI-78473; Q13547:HDAC1; NbExp=4; IntAct=EBI-300010, EBI-301834; P25963:NFKBIA; NbExp=2; IntAct=EBI-300010, EBI-307386; Q14690:PDCD11; NbExp=2; IntAct=EBI-300010, EBI-300028; Q8IZL8:PELP1; NbExp=2; IntAct=EBI-300010, EBI-716449; Q8IV08:PLD3; NbExp=2; IntAct=EBI-300010, EBI-2689908; Q04206:RELA; NbExp=9; IntAct=EBI-300010, EBI-73886; P23396:RPS3; NbExp=2; IntAct=EBI-300010, EBI-351193; Q8NFZ5:TNIP2; NbExp=8; IntAct=EBI-1452239, EBI-359372;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
INDUCTION: By phorbol ester and TNF.
DOMAIN: The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation.
DOMAIN: Glycine-rich region (GRR) appears to be a critical element in the generation of p50.
PTM: While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
PTM: Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis.
PTM: Polyubiquitination seems to allow p105 processing.
PTM: S-nitrosylation of Cys-61 affects DNA binding.
PTM: The covalent modification of cysteine by 15-deoxy-Delta12,14- prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S- nitrosylation and S-palmitoylation.
SIMILARITY: Contains 7 ANK repeats.
SIMILARITY: Contains 1 death domain.
SIMILARITY: Contains 1 RHD (Rel-like) domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NFKB1ID323.html";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nfkb1/";

-  MalaCards Disease Associations
  MalaCards Gene Search: NFKB1
Diseases sorted by gene-association score: immunodeficiency, common variable, 12* (919), common variable immunodeficiency* (128), asherman's syndrome (18), intestinal perforation (18), human t-cell leukemia virus type 2 (10), scar contracture (10), crimean-congo hemorrhagic fever (8), human t-cell leukemia virus type 1 (7), tropical spastic paraparesis (7), t-cell prolymphocytic leukemia (6), hepatocellular carcinoma (3), colorectal cancer (2), obesity (2), prostate cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.06 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 459.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -227.10465-0.488 Picture PostScript Text
3' UTR -87.80321-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR000488 - Death
IPR011029 - DEATH-like
IPR013783 - Ig-like_fold
IPR014756 - Ig_E-set
IPR002909 - IPT_TIG_rcpt
IPR000451 - NF_Rel_dor
IPR008967 - p53-like_TF_DNA-bd
IPR011539 - RHD

Pfam Domains:
PF00023 - Ankyrin repeat
PF00531 - Death domain
PF00554 - Rel homology DNA-binding domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1MDI
- NMR MuPIT

1MDJ
- NMR MuPIT

1MDK
- NMR MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
1NFI - X-ray MuPIT 1SVC - X-ray MuPIT 2DBF - NMR MuPIT
2O61 - X-ray MuPIT 3GUT - X-ray


ModBase Predicted Comparative 3D Structure on P19838
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042805 actinin binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001818 negative regulation of cytokine production
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0010629 negative regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032375 negative regulation of cholesterol transport
GO:0032481 positive regulation of type I interferon production
GO:0035994 response to muscle stretch
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0045083 negative regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050728 negative regulation of inflammatory response
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071359 cellular response to dsRNA
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1904385 cellular response to angiotensin
GO:2000630 positive regulation of miRNA metabolic process

Cellular Component:
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0033256 I-kappaB/NF-kappaB complex
GO:0034774 secretory granule lumen
GO:0035580 specific granule lumen


-  Descriptions from all associated GenBank mRNAs
  LF213714 - JP 2014500723-A/21217: Polycomb-Associated Non-Coding RNAs.
MA449291 - JP 2018138019-A/21217: Polycomb-Associated Non-Coding RNAs.
BC051765 - Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, mRNA (cDNA clone MGC:54151 IMAGE:6500087), complete cds.
JB406677 - Sequence 3 from Patent WO2012072685.
JB406679 - Sequence 5 from Patent WO2012072685.
M58603 - Human nuclear factor kappa-B DNA binding subunit (NF-kappa-B) mRNA, complete cds.
JD140720 - Sequence 121744 from Patent EP1572962.
JD458416 - Sequence 439440 from Patent EP1572962.
JD179796 - Sequence 160820 from Patent EP1572962.
JD111758 - Sequence 92782 from Patent EP1572962.
JD199183 - Sequence 180207 from Patent EP1572962.
M55643 - Human factor KBF1 mRNA, complete cds.
JD210375 - Sequence 191399 from Patent EP1572962.
JD458695 - Sequence 439719 from Patent EP1572962.
AK291450 - Homo sapiens cDNA FLJ78654 complete cds, highly similar to Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) (NFKB1), mRNA.
JD179673 - Sequence 160697 from Patent EP1572962.
CR749522 - Homo sapiens mRNA; cDNA DKFZp686C01211 (from clone DKFZp686C01211).
CU690836 - Synthetic construct Homo sapiens gateway clone IMAGE:100021551 5' read NFKB1 mRNA.
AB489154 - Synthetic construct DNA, clone: pF1KB3126, Homo sapiens NFKB1 gene for nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, without stop codon, in Flexi system.
EU446640 - Synthetic construct Homo sapiens clone IMAGE:100070280; IMAGE:100011849; FLH258383.01L nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) (NFKB1) gene, encodes complete protein.
KJ897243 - Synthetic construct Homo sapiens clone ccsbBroadEn_06637 NFKB1 gene, encodes complete protein.
AK122850 - Homo sapiens cDNA FLJ16470 fis, clone BRHIP3009181, highly similar to NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT.
BC033210 - Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, mRNA (cDNA clone IMAGE:4906270), partial cds.
JD417839 - Sequence 398863 from Patent EP1572962.
JD454593 - Sequence 435617 from Patent EP1572962.
JD561131 - Sequence 542155 from Patent EP1572962.
JD243023 - Sequence 224047 from Patent EP1572962.
JD368004 - Sequence 349028 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa01100 - Metabolic pathways
hsa04010 - MAPK signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04210 - Apoptosis
hsa04620 - Toll-like receptor signaling pathway
hsa04621 - NOD-like receptor signaling pathway
hsa04622 - RIG-I-like receptor signaling pathway
hsa04623 - Cytosolic DNA-sensing pathway
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04722 - Neurotrophin signaling pathway
hsa04920 - Adipocytokine signaling pathway
hsa05120 - Epithelial cell signaling in Helicobacter pylori infection
hsa05131 - Shigellosis
hsa05140 - Leishmaniasis
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05212 - Pancreatic cancer
hsa05215 - Prostate cancer
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05222 - Small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_atmPathway - ATM Signaling Pathway
h_keratinocytePathway - Keratinocyte Differentiation
h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae
h_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_ceramidePathway - Ceramide Signaling Pathway
h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors
h_freePathway - Free Radical Induced Apoptosis
h_ranklPathway - Bone Remodelling
h_stressPathway - TNF/Stress Related Signaling
h_tcrPathway - T Cell Receptor Signaling Pathway
h_nfkbPathway - NF-kB Signaling Pathway
h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
h_gcrPathway - Corticosteroids and cardioprotection
h_tnfr2Pathway - TNFR2 Signaling Pathway
h_il1rPathway - Signal transduction through IL1R
h_pkcPathway - Activation of PKC through G protein coupled receptor
h_rnaPathway - Double Stranded RNA Induced Gene Expression
h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
h_RELAPathway - Acetylation and Deacetylation of RelA in The Nucleus
h_eponfkbPathway - Erythropoietin mediated neuroprotection through NF-kB
h_41bbPathway - The 4-1BB-dependent immune response
h_aktPathway - AKT Signaling Pathway
h_cd40Pathway - CD40L Signaling Pathway
h_cxcr4Pathway - CXCR4 Signaling Pathway
h_pcafpathway - The information-processing pathway at the IFN-beta enhancer
h_tall1Pathway - TACI and BCMA stimulation of B cell immune responses.
h_tidPathway - Chaperones modulate interferon Signaling Pathway
h_tollPathway - Toll-Like Receptor Pathway
h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages
h_mapkPathway - MAPKinase Signaling Pathway
h_rasPathway - Ras Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P19838 (Reactome details) participates in the following event(s):

R-HSA-451634 NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
R-HSA-193691 NF-kB migrates to the nucleus and turns on transcription
R-HSA-193700 p75NTR ICD signals to NF-kB
R-HSA-193705 IKKbeta phosphorylates IkB causing NF-kB to dissociate
R-HSA-209125 SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex
R-HSA-3857305 Activated CEBPB and NFKB complex bind IL6 promoter
R-HSA-3857308 Activated CEBPB and NFKB complex bind IL8 promoter
R-HSA-5624473 Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
R-HSA-5660666 CBP and p300 binds NF-kB complex
R-HSA-5684261 MAP3K8 is phosphorylated
R-HSA-5684267 IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
R-HSA-5684275 IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
R-HSA-5684248 SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
R-HSA-5684250 SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
R-HSA-6798749 Exocytosis of specific granule lumen proteins
R-HSA-6798748 Exocytosis of secretory granule lumen proteins
R-HSA-202541 p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
R-HSA-209063 Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex
R-HSA-168166 NFkB complex is transported from cytosol to nucleus
R-HSA-168140 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
R-HSA-5660660 p300 acetylates RELA subunit
R-HSA-8865237 SETD6 methylates RELA in the NFkB complex
R-HSA-1168638 Activated IKK phosphorylates I-kappaB
R-HSA-1168642 SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-193692 Regulated proteolysis of p75NTR
R-HSA-202424 Downstream TCR signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-9020702 Interleukin-1 signaling
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-450294 MAP kinase activation
R-HSA-6798695 Neutrophil degranulation
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-193639 p75NTR signals via NF-kB
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-202403 TCR signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-446652 Interleukin-1 family signaling
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-933542 TRAF6 mediated NF-kB activation
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-2559583 Cellular Senescence
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-168249 Innate Immune System
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-73887 Death Receptor Signalling
R-HSA-1280218 Adaptive Immune System
R-HSA-449147 Signaling by Interleukins
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-2262752 Cellular responses to stress
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168256 Immune System
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-162582 Signal Transduction
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-5602358 Diseases associated with the TLR signaling cascade
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-4839726 Chromatin organization
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-5260271 Diseases of Immune System
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A8K5Y5, B3KVE8, NFKB1_HUMAN, NM_001165412, P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0, uc011ceq.1, uc011ceq.2, uc011ceq.3
UCSC ID: uc011ceq.3
RefSeq Accession: NM_001165412
Protein: P19838 (aka NFKB1_HUMAN)
CCDS: CCDS3657.1, CCDS54783.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.