Human Gene CPSF7 (ENST00000394888.8) Description and Page Index
Description: Homo sapiens cleavage and polyadenylation specific factor 7 (CPSF7), transcript variant 2, mRNA. (from RefSeq NM_001136040) RefSeq Summary (NM_001136040): Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016]. Gencode Transcript: ENST00000394888.8 Gencode Gene: ENSG00000149532.15 Transcript (Including UTRs) Position: hg38 chr11:61,402,649-61,430,031 Size: 27,383 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr11:61,410,943-61,429,235 Size: 18,293 Coding Exon Count: 8
ID:CPSF7_HUMAN DESCRIPTION: RecName: Full=Cleavage and polyadenylation specificity factor subunit 7; AltName: Full=Cleavage and polyadenylation specificity factor 59 kDa subunit; Short=CFIm59; Short=CPSF 59 kDa subunit; AltName: Full=Pre-mRNA cleavage factor Im 59 kDa subunit; FUNCTION: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3' processing. Binds to cleavage and polyadenylation RNA substrates. SUBUNIT: Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5. INTERACTION: P54253:ATXN1; NbExp=2; IntAct=EBI-746909, EBI-930964; SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the RRM CPSF6/7 family. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SEQUENCE CAUTION: Sequence=AAH18135.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14118.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD97884.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N684
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.