Human Gene YPEL3 (ENST00000398838.8) Description and Page Index
  Description: Homo sapiens yippee like 3 (YPEL3), transcript variant 2, mRNA. (from RefSeq NM_001145524)
Gencode Transcript: ENST00000398838.8
Gencode Gene: ENSG00000090238.12
Transcript (Including UTRs)
   Position: hg38 chr16:30,092,349-30,096,244 Size: 3,896 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr16:30,092,710-30,095,368 Size: 2,659 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:30,092,349-30,096,244)mRNA (may differ from genome)Protein (119 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: YPEL3_HUMAN
DESCRIPTION: RecName: Full=Protein yippee-like 3;
FUNCTION: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity).
SUBCELLULAR LOCATION: Nucleus, nucleolus.
TISSUE SPECIFICITY: Widely expressed.
PTM: Probably ubiquitinated leading to its degradation by the proteasome (By similarity).
SIMILARITY: Belongs to the yippee family.
SEQUENCE CAUTION: Sequence=EAW79925.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 127.56 RPKM in Whole Blood
Total median expression: 1916.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -118.10214-0.552 Picture PostScript Text
3' UTR -130.40361-0.361 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004910 - Yippee

Pfam Domains:
PF03226 - Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

ModBase Predicted Comparative 3D Structure on P61236
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Biological Process:
GO:2000774 positive regulation of cellular senescence

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  LF207899 - JP 2014500723-A/15402: Polycomb-Associated Non-Coding RNAs.
MA443476 - JP 2018138019-A/15402: Polycomb-Associated Non-Coding RNAs.
BC005009 - Homo sapiens yippee-like 3 (Drosophila), mRNA (cDNA clone MGC:10500 IMAGE:3639517), complete cds.
BC050664 - Homo sapiens yippee-like 3 (Drosophila), mRNA (cDNA clone MGC:60184 IMAGE:5748830), complete cds.
AB098737 - Homo sapiens YPEL3 mRNA for yippee-like 3, complete cds.
AF305622 - Homo sapiens DiGeorge syndrome-related protein FKSG5 mRNA, complete cds.
JD485319 - Sequence 466343 from Patent EP1572962.
JD565401 - Sequence 546425 from Patent EP1572962.
JD391537 - Sequence 372561 from Patent EP1572962.
JD149208 - Sequence 130232 from Patent EP1572962.
JD517140 - Sequence 498164 from Patent EP1572962.
JD057083 - Sequence 38107 from Patent EP1572962.
JD282857 - Sequence 263881 from Patent EP1572962.
JD125042 - Sequence 106066 from Patent EP1572962.
KJ906353 - Synthetic construct Homo sapiens clone ccsbBroadEn_16023 YPEL3 gene, encodes complete protein.
KJ903359 - Synthetic construct Homo sapiens clone ccsbBroadEn_12753 YPEL3 gene, encodes complete protein.
AK026047 - Homo sapiens cDNA: FLJ22394 fis, clone HRC07882.
AK022409 - Homo sapiens cDNA FLJ12347 fis, clone MAMMA1002298.

-  Other Names for This Gene
  Alternate Gene Symbols: FKSG5, NM_001145524, P61236, Q65Z99, Q86VK6, Q9BSJ4, Q9CQB6, uc002dwm.1, uc002dwm.2, uc002dwm.3, uc002dwm.4, YPEL3_HUMAN
UCSC ID: uc002dwm.4
RefSeq Accession: NM_001145524
Protein: P61236 (aka YPEL3_HUMAN or YPL3_HUMAN)
CCDS: CCDS45459.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.