Human Gene MDGA2 (ENST00000399232.8) Description and Page Index
  Description: May involved in cell-cell interactions (By similarity). (from UniProt Q7Z553)
Gencode Transcript: ENST00000399232.8
Gencode Gene: ENSG00000139915.20
Transcript (Including UTRs)
   Position: hg38 chr14:46,840,092-47,675,605 Size: 835,514 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg38 chr14:46,841,931-47,674,796 Size: 832,866 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:46,840,092-47,675,605)mRNA (may differ from genome)Protein (1025 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: MDGA2_HUMAN
DESCRIPTION: RecName: Full=MAM domain-containing glycosylphosphatidylinositol anchor protein 2; AltName: Full=MAM domain-containing protein 1; Flags: Precursor;
FUNCTION: May involved in cell-cell interactions (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (Potential).
SIMILARITY: Contains 6 Ig-like (immunoglobulin-like) domains.
SIMILARITY: Contains 1 MAM domain.
SEQUENCE CAUTION: Sequence=AAP97010.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.42 RPKM in Testis
Total median expression: 0.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -339.90809-0.420 Picture PostScript Text
3' UTR -406.301839-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR003961 - Fibronectin_type3
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR000998 - MAM_dom

Pfam Domains:
PF07679 - Immunoglobulin I-set domain
PF00629 - MAM domain, meprin/A5/mu

ModBase Predicted Comparative 3D Structure on Q7Z553
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0021522 spinal cord motor neuron differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY369208 - Homo sapiens MAM domain-containing glycosylphosphatidylinositol anchor 2 (MDGA2) mRNA, complete cds.
AK309211 - Homo sapiens cDNA, FLJ99252.
AY358125 - Homo sapiens clone DNA180829 MAM-domain protein (UNQ8188) mRNA, partial cds.
BC142947 - Homo sapiens cDNA clone IMAGE:8860330.
BC028193 - Homo sapiens MAM domain containing glycosylphosphatidylinositol anchor 2, mRNA (cDNA clone IMAGE:5165468), with apparent retained intron.
AY328482 - Homo sapiens MAM domain containing 1 (MAMDC1) mRNA, complete cds.
BC160160 - Synthetic construct Homo sapiens clone IMAGE:100064192, MGC:193275 MAM domain containing glycosylphosphatidylinositol anchor 2 (MDGA2) mRNA, encodes complete protein.
BX538065 - Homo sapiens mRNA; cDNA DKFZp686N01198 (from clone DKFZp686N01198).
AK123307 - Homo sapiens cDNA FLJ41313 fis, clone BRAMY2042899, highly similar to MAM domain-containing protein 1.
JD188244 - Sequence 169268 from Patent EP1572962.
JD565927 - Sequence 546951 from Patent EP1572962.
JD118667 - Sequence 99691 from Patent EP1572962.
JD039023 - Sequence 20047 from Patent EP1572962.
JD510852 - Sequence 491876 from Patent EP1572962.
JD380868 - Sequence 361892 from Patent EP1572962.
JD357801 - Sequence 338825 from Patent EP1572962.
JD317299 - Sequence 298323 from Patent EP1572962.
JD204363 - Sequence 185387 from Patent EP1572962.
JD257448 - Sequence 238472 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z553 (Reactome details) participates in the following event(s):

R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: AY369208, F6W3S7, MAMDC1, MDGA2_HUMAN, Q7Z553, uc001wwj.1, uc001wwj.2, uc001wwj.3, uc001wwj.4, uc001wwj.5, uc001wwj.6, uc001wwj.7, uc001wwj.8, UNQ8188/PRO23197
UCSC ID: uc001wwj.8
RefSeq Accession: NM_001113498
Protein: Q7Z553 (aka MDGA2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.