Human Gene MDGA2 (ENST00000399232.8) Description and Page Index
  Description: May involved in cell-cell interactions (By similarity). (from UniProt Q7Z553)
Gencode Transcript: ENST00000399232.8
Gencode Gene: ENSG00000139915.20
Transcript (Including UTRs)
   Position: hg38 chr14:46,840,092-47,675,605 Size: 835,514 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg38 chr14:46,841,931-47,674,796 Size: 832,866 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:46,840,092-47,675,605)mRNA (may differ from genome)Protein (1025 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=MAM domain-containing glycosylphosphatidylinositol anchor protein 2; AltName: Full=MAM domain-containing protein 1; Flags: Precursor;
FUNCTION: May involved in cell-cell interactions (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (Potential).
SIMILARITY: Contains 6 Ig-like (immunoglobulin-like) domains.
SIMILARITY: Contains 1 MAM domain.
SEQUENCE CAUTION: Sequence=AAP97010.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.42 RPKM in Testis
Total median expression: 0.51 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -339.90809-0.420 Picture PostScript Text
3' UTR -406.301839-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR003961 - Fibronectin_type3
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR000998 - MAM_dom

Pfam Domains:
PF07679 - Immunoglobulin I-set domain
PF00629 - MAM domain, meprin/A5/mu

ModBase Predicted Comparative 3D Structure on Q7Z553
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0021522 spinal cord motor neuron differentiation

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane

-  Descriptions from all associated GenBank mRNAs
  AY369208 - Homo sapiens MAM domain-containing glycosylphosphatidylinositol anchor 2 (MDGA2) mRNA, complete cds.
AK309211 - Homo sapiens cDNA, FLJ99252.
AY358125 - Homo sapiens clone DNA180829 MAM-domain protein (UNQ8188) mRNA, partial cds.
BC142947 - Homo sapiens cDNA clone IMAGE:8860330.
BC028193 - Homo sapiens MAM domain containing glycosylphosphatidylinositol anchor 2, mRNA (cDNA clone IMAGE:5165468), with apparent retained intron.
AY328482 - Homo sapiens MAM domain containing 1 (MAMDC1) mRNA, complete cds.
BC160160 - Synthetic construct Homo sapiens clone IMAGE:100064192, MGC:193275 MAM domain containing glycosylphosphatidylinositol anchor 2 (MDGA2) mRNA, encodes complete protein.
BX538065 - Homo sapiens mRNA; cDNA DKFZp686N01198 (from clone DKFZp686N01198).
AK123307 - Homo sapiens cDNA FLJ41313 fis, clone BRAMY2042899, highly similar to MAM domain-containing protein 1.
JD188244 - Sequence 169268 from Patent EP1572962.
JD565927 - Sequence 546951 from Patent EP1572962.
JD118667 - Sequence 99691 from Patent EP1572962.
JD039023 - Sequence 20047 from Patent EP1572962.
JD510852 - Sequence 491876 from Patent EP1572962.
JD380868 - Sequence 361892 from Patent EP1572962.
JD357801 - Sequence 338825 from Patent EP1572962.
JD317299 - Sequence 298323 from Patent EP1572962.
JD204363 - Sequence 185387 from Patent EP1572962.
JD257448 - Sequence 238472 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z553 (Reactome details) participates in the following event(s):

R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: AY369208, F6W3S7, MAMDC1, MDGA2_HUMAN, Q7Z553, uc001wwj.1, uc001wwj.2, uc001wwj.3, uc001wwj.4, uc001wwj.5, uc001wwj.6, uc001wwj.7, uc001wwj.8, UNQ8188/PRO23197
UCSC ID: uc001wwj.8
RefSeq Accession: NM_001113498
Protein: Q7Z553 (aka MDGA2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.