Human Gene EIF4G3 (ENST00000400422.6) from GENCODE V38
  Description: Homo sapiens eukaryotic translation initiation factor 4 gamma 3 (EIF4G3), transcript variant 1, mRNA. (from RefSeq NM_001198801)
RefSeq Summary (NM_001198801): The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016].
Gencode Transcript: ENST00000400422.6
Gencode Gene: ENSG00000075151.23
Transcript (Including UTRs)
   Position: hg38 chr1:20,807,004-21,176,847 Size: 369,844 Total Exon Count: 35 Strand: -
Coding Region
   Position: hg38 chr1:20,807,319-21,002,742 Size: 195,424 Coding Exon Count: 31 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:20,807,004-21,176,847)mRNA (may differ from genome)Protein (1621 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.17 RPKM in Testis
Total median expression: 592.78 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -208.90581-0.360 Picture PostScript Text
3' UTR -49.90315-0.158 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AF012072 - Homo sapiens eIF4GII mRNA, complete cds.
AB209119 - Homo sapiens mRNA for eukaryotic translation initiation factor 4 gamma, 3 variant protein.
BC094683 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:102792 IMAGE:6188273), complete cds.
BC072413 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:6165611), partial cds.
BC136643 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:168256 IMAGE:9020633), complete cds.
BC144335 - Homo sapiens cDNA clone IMAGE:9052855, containing frame-shift errors.
AK294883 - Homo sapiens cDNA FLJ59298 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 3.
AK225489 - Homo sapiens mRNA for Splice isoform 2 of O43432 variant, clone: JTH03575.
BC030578 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:4836870), complete cds.
AK302087 - Homo sapiens cDNA FLJ60945 complete cds, highly similar to Eukaryotic translation initiation factor 4gamma 3.
AK302873 - Homo sapiens cDNA FLJ53944 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 3.
Z34918 - H.sapiens mRNA for translation initiation factor eIF-4gamma (partial).
JD164334 - Sequence 145358 from Patent EP1572962.
JD102602 - Sequence 83626 from Patent EP1572962.
AK310195 - Homo sapiens cDNA, FLJ17237.
BX647897 - Homo sapiens mRNA; cDNA DKFZp686C17112 (from clone DKFZp686C17112).
JD244587 - Sequence 225611 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05416 - Viral myocarditis

BioCarta from NCI Cancer Genome Anatomy Project
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_eifPathway - Eukaryotic protein translation
h_mTORPathway - mTOR Signaling Pathway
h_iresPathway - Internal Ribosome entry pathway

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MSA7, ENST00000400422.1, ENST00000400422.2, ENST00000400422.3, ENST00000400422.4, ENST00000400422.5, NM_001198801, uc001bef.1, uc001bef.2, uc001bef.3, uc001bef.4
UCSC ID: ENST00000400422.6
RefSeq Accession: NM_001198801
CCDS: CCDS214.1, CCDS55580.1, CCDS72723.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.