Human Gene FGG (ENST00000407946.5) Description and Page Index
  Description: Contains 1 fibrinogen C-terminal domain. (from UniProt C9JC84)
RefSeq Summary (NM_021870): The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
Gencode Transcript: ENST00000407946.5
Gencode Gene: ENSG00000171557.17
Transcript (Including UTRs)
   Position: hg38 chr4:154,604,610-154,612,635 Size: 8,026 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr4:154,604,834-154,612,609 Size: 7,776 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:154,604,610-154,612,635)mRNA (may differ from genome)Protein (461 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Fibrinogen gamma chain;
SIMILARITY: Contains 1 fibrinogen C-terminal domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: FGG
Diseases sorted by gene-association score: dysfibrinogenemia, congenital* (1579), afibrinogenemia, congenital* (1118), afibrinogenemia* (260), fgg-related congenital afibrinogenemia* (100), dysfibrinogenemia (35), inherited blood coagulation disease (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4155.87 RPKM in Liver
Total median expression: 4178.85 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.6026-0.215 Picture PostScript Text
3' UTR -29.40224-0.131 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002181 - Fibrinogen_a/b/g_C
IPR014716 - Fibrinogen_a/b/g_C_1
IPR014715 - Fibrinogen_a/b/g_C_2
IPR012290 - Fibrinogen_a/b/g_coil_dom
IPR020837 - Fibrinogen_CS

Pfam Domains:
PF08702 - Fibrinogen alpha/beta chain family
PF00147 - Fibrinogen beta and gamma chains, C-terminal globular domain

ModBase Predicted Comparative 3D Structure on C9JC84
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding

Biological Process:
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0051258 protein polymerization

Cellular Component:
GO:0005577 fibrinogen complex

-  Descriptions from all associated GenBank mRNAs
  AF118092 - Homo sapiens PRO2061 mRNA, complete cds.
BX538098 - Homo sapiens mRNA; cDNA DKFZp779N0926 (from clone DKFZp779N0926).
AK290824 - Homo sapiens cDNA FLJ75335 complete cds, highly similar to Homo sapiens fibrinogen gamma chain, transcript variant gamma-A, mRNA.
BC007044 - Homo sapiens fibrinogen gamma chain, mRNA (cDNA clone MGC:12444 IMAGE:3934943), complete cds.
BC021674 - Homo sapiens fibrinogen gamma chain, mRNA (cDNA clone MGC:22849 IMAGE:3935073), complete cds.
HM005383 - Homo sapiens clone HTL-T-70 testicular tissue protein Li 70 mRNA, complete cds.
BT007081 - Homo sapiens fibrinogen, gamma polypeptide mRNA, complete cds.
KJ891169 - Synthetic construct Homo sapiens clone ccsbBroadEn_00563 FGG gene, encodes complete protein.
KR710136 - Synthetic construct Homo sapiens clone CCSBHm_00009987 FGG (FGG) mRNA, encodes complete protein.
KR710137 - Synthetic construct Homo sapiens clone CCSBHm_00009989 FGG (FGG) mRNA, encodes complete protein.
KR710138 - Synthetic construct Homo sapiens clone CCSBHm_00010009 FGG (FGG) mRNA, encodes complete protein.
KR710139 - Synthetic construct Homo sapiens clone CCSBHm_00010029 FGG (FGG) mRNA, encodes complete protein.
JD114084 - Sequence 95108 from Patent EP1572962.
AK289422 - Homo sapiens cDNA FLJ75296 complete cds, highly similar to Homo sapiens fibrinogen, gamma polypeptide (FGG), transcriptvariant gamma-B, mRNA.
AB527926 - Synthetic construct DNA, clone: pF1KB6666, Homo sapiens FGG gene for fibrinogen gamma chain, without stop codon, in Flexi system.
X51473 - Human mRNA for fibrinogen gamma chain (partial).
CU675513 - Synthetic construct Homo sapiens gateway clone IMAGE:100017264 5' read FGG mRNA.
X00086 - Human mRNA for fragment of A-gamma-fibrinogen chain.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04610 - Complement and coagulation cascades

BioCarta from NCI Cancer Genome Anatomy Project
h_intrinsicPathway - Intrinsic Prothrombin Activation Pathway
h_extrinsicPathway - Extrinsic Prothrombin Activation Pathway
h_amiPathway - Acute Myocardial Infarction
h_fibrinolysisPathway - Fibrinolysis Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: AK289422, C9JC84, C9JC84_HUMAN, uc063ajy.1
UCSC ID: uc063ajy.1
RefSeq Accession: NM_021870
Protein: C9JC84 CCDS: CCDS3788.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.