Human Gene FGG (ENST00000407946.5) Description and Page Index
Description: Contains 1 fibrinogen C-terminal domain. (from UniProt C9JC84) RefSeq Summary (NM_021870): The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]. Gencode Transcript: ENST00000407946.5 Gencode Gene: ENSG00000171557.17 Transcript (Including UTRs) Position: hg38 chr4:154,604,610-154,612,635 Size: 8,026 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr4:154,604,834-154,612,609 Size: 7,776 Coding Exon Count: 9
ID:C9JC84_HUMAN DESCRIPTION: SubName: Full=Fibrinogen gamma chain; SIMILARITY: Contains 1 fibrinogen C-terminal domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08702 - Fibrinogen alpha/beta chain family PF00147 - Fibrinogen beta and gamma chains, C-terminal globular domain
ModBase Predicted Comparative 3D Structure on C9JC84
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.