Human Gene DCN (ENST00000425043.5) Description and Page Index
  Description: Homo sapiens decorin (DCN), transcript variant C, mRNA. (from RefSeq NM_133505)
RefSeq Summary (NM_133505): This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015].
Gencode Transcript: ENST00000425043.5
Gencode Gene: ENSG00000011465.17
Transcript (Including UTRs)
   Position: hg38 chr12:91,145,259-91,178,552 Size: 33,294 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr12:91,146,058-91,178,552 Size: 32,495 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesGeneReviewsMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:91,145,259-91,178,552)mRNA (may differ from genome)Protein (212 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PGS2_HUMAN
DESCRIPTION: RecName: Full=Decorin; AltName: Full=Bone proteoglycan II; AltName: Full=PG-S2; AltName: Full=PG40; Flags: Precursor;
FUNCTION: May affect the rate of fibrils formation.
SUBUNIT: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
PTM: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
DISEASE: Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance.
SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
SIMILARITY: Contains 12 LRR (leucine-rich) repeats.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/dcn/";

-  MalaCards Disease Associations
  MalaCards Gene Search: DCN
Diseases sorted by gene-association score: corneal dystrophy, congenital stromal* (1377), stromal dystrophy (24), interstitial keratitis (22), localized scleroderma (19), dupuytren contracture (13), neonatal marfan syndrome (13), eosinophilic granuloma (12), cornea plana (12), corneal dystrophy (11), pseudoachondroplasia (10), marfan syndrome (9), renal artery atheroma (9), peyronie's disease (8), gingival overgrowth (8), primary hypertrophic osteoarthropathy (8), crouzon syndrome (7), multiple epiphyseal dysplasia (6), achondrogenesis ib (6), odontogenic myxoma (5), tendinosis (4), nephrogenic systemic fibrosis (4), osseous heteroplasia, progressive (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 388.95 RPKM in Ovary
Total median expression: 5935.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -143.00799-0.179 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N
IPR016352 - SLRP_I_decor/aspor/byglycan

Pfam Domains:
PF01462 - Leucine rich repeat N-terminal domain

ModBase Predicted Comparative 3D Structure on P07585
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0005539 glycosaminoglycan binding
GO:0047485 protein N-terminus binding
GO:0050840 extracellular matrix binding

Biological Process:
GO:0001822 kidney development
GO:0001890 placenta development
GO:0006469 negative regulation of protein kinase activity
GO:0007519 skeletal muscle tissue development
GO:0007568 aging
GO:0009612 response to mechanical stimulus
GO:0009887 animal organ morphogenesis
GO:0010508 positive regulation of autophagy
GO:0010596 negative regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016239 positive regulation of macroautophagy
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0030198 extracellular matrix organization
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030207 chondroitin sulfate catabolic process
GO:0030208 dermatan sulfate biosynthetic process
GO:0032496 response to lipopolysaccharide
GO:0042060 wound healing
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046426 negative regulation of JAK-STAT cascade
GO:0051901 positive regulation of mitochondrial depolarization
GO:0090141 positive regulation of mitochondrial fission
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005589 collagen type VI trimer
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0031012 extracellular matrix
GO:0043202 lysosomal lumen


-  Descriptions from all associated GenBank mRNAs
  KJ891032 - Synthetic construct Homo sapiens clone ccsbBroadEn_00426 DCN gene, encodes complete protein.
LF384686 - JP 2014500723-A/192189: Polycomb-Associated Non-Coding RNAs.
MA620263 - JP 2018138019-A/192189: Polycomb-Associated Non-Coding RNAs.
BX571756 - Homo sapiens mRNA; cDNA DKFZp686J19238 (from clone DKFZp686J19238).
JD379286 - Sequence 360310 from Patent EP1572962.
LF323599 - JP 2014500723-A/131102: Polycomb-Associated Non-Coding RNAs.
MA559176 - JP 2018138019-A/131102: Polycomb-Associated Non-Coding RNAs.
JD148611 - Sequence 129635 from Patent EP1572962.
AK291309 - Homo sapiens cDNA FLJ75936 complete cds, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA.
LF323598 - JP 2014500723-A/131101: Polycomb-Associated Non-Coding RNAs.
MA559175 - JP 2018138019-A/131101: Polycomb-Associated Non-Coding RNAs.
BC005322 - Homo sapiens decorin, mRNA (cDNA clone MGC:12406 IMAGE:3934022), complete cds.
JD550172 - Sequence 531196 from Patent EP1572962.
LF323597 - JP 2014500723-A/131100: Polycomb-Associated Non-Coding RNAs.
MA559174 - JP 2018138019-A/131100: Polycomb-Associated Non-Coding RNAs.
M14219 - Human chondroitin/dermatan sulfate proteoglycan (PG40) core protein mRNA, complete cds.
LF323596 - JP 2014500723-A/131099: Polycomb-Associated Non-Coding RNAs.
MA559173 - JP 2018138019-A/131099: Polycomb-Associated Non-Coding RNAs.
AF138300 - Homo sapiens decorin variant A mRNA, complete cds.
AF138301 - Homo sapiens decorin B mRNA, complete cds, alternatively spliced.
AF138302 - Homo sapiens decorin variant C mRNA, complete cds.
AF138303 - Homo sapiens decorin D mRNA, complete cds, alternatively spliced.
CR541946 - Homo sapiens full open reading frame cDNA clone RZPDo834D1134D for gene DCN, decorin; complete cds, incl. stopcodon.
BT019800 - Homo sapiens decorin mRNA, complete cds.
DQ892556 - Synthetic construct clone IMAGE:100005186; FLH187471.01X; RZPDo839H0872D decorin (DCN) gene, encodes complete protein.
DQ895769 - Synthetic construct Homo sapiens clone IMAGE:100010229; FLH187467.01L; RZPDo839H0862D decorin (DCN) gene, encodes complete protein.
CR407676 - Homo sapiens full open reading frame cDNA clone RZPDo834C053D for gene DCN, decorin complete cds, without stopcodon.
KU178017 - Homo sapiens decorin isoform 1 (DCN) mRNA, partial cds.
KU178018 - Homo sapiens decorin isoform 2 (DCN) mRNA, partial cds, alternatively spliced.
KU178019 - Homo sapiens decorin isoform 3 (DCN) mRNA, complete cds, alternatively spliced.
KU178020 - Homo sapiens decorin isoform 4 (DCN) mRNA, complete cds, alternatively spliced.
AB463564 - Synthetic construct DNA, clone: pF1KB6509, Homo sapiens DCN gene for decorin, without stop codon, in Flexi system.
CU675109 - Synthetic construct Homo sapiens gateway clone IMAGE:100017098 5' read DCN mRNA.
JD263067 - Sequence 244091 from Patent EP1572962.
JD508954 - Sequence 489978 from Patent EP1572962.
LF323595 - JP 2014500723-A/131098: Polycomb-Associated Non-Coding RNAs.
MA559172 - JP 2018138019-A/131098: Polycomb-Associated Non-Coding RNAs.
AF138304 - Homo sapiens decorin variant E mRNA, complete cds.
LF323594 - JP 2014500723-A/131097: Polycomb-Associated Non-Coding RNAs.
MA559171 - JP 2018138019-A/131097: Polycomb-Associated Non-Coding RNAs.
LF323593 - JP 2014500723-A/131096: Polycomb-Associated Non-Coding RNAs.
MA559170 - JP 2018138019-A/131096: Polycomb-Associated Non-Coding RNAs.
AL355731 - Homo sapiens EST from clone 130486, 5' end.
LF323586 - JP 2014500723-A/131089: Polycomb-Associated Non-Coding RNAs.
MA559163 - JP 2018138019-A/131089: Polycomb-Associated Non-Coding RNAs.
JD023146 - Sequence 4170 from Patent EP1572962.
JD034857 - Sequence 15881 from Patent EP1572962.
JD249379 - Sequence 230403 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04350 - TGF-beta signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_slrpPathway - Small Leucine-rich Proteoglycan (SLRP) molecules

Reactome (by CSHL, EBI, and GO)

Protein P07585 (Reactome details) participates in the following event(s):

R-HSA-2327909 DCN binds collagen I, II, III, VI fibrils
R-HSA-2534248 DCN (decorin) degradation by MMP2, MMP3, MMP7
R-HSA-3828025 DCN (decorin) degradation by MMP14
R-HSA-2327886 SLRPs bind TGF Beta
R-NUL-2466133 SLRPs bind TGF beta
R-HSA-1971487 CHPF,CHSY1,CHSY3 transfer GalNAc to chondroitin
R-HSA-1971491 CHPF,CHPF2,CHSY1,CHSY3 transfer GlcA to chondroitin
R-HSA-1878002 XYLTs transfer Xyl to core protein
R-HSA-1971483 Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13
R-HSA-2018682 CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains
R-HSA-2018659 Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15
R-HSA-1889955 B3GATs transfer GlcA to tetrasaccharide linker
R-HSA-1889978 B3GALT6 transfers Gal to the tetrasaccharide linker
R-HSA-1889981 B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker
R-HSA-1971482 The addition of GalNAc to the terminal glucuronate residue forms chondroitin
R-HSA-2022061 Dermatan sulfate can be further sulfated on position 2 of iduronate
R-HSA-2022052 Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)
R-HSA-2022063 CHST14 transfers SO4(2-) to GalNAc in dermatan or DS
R-HSA-3000178 ECM proteoglycans
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474244 Extracellular matrix organization
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism
R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-3781865 Diseases of glycosylation
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1643685 Disease
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: NM_133505, P07585, PGS2_HUMAN, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9, SLRR1B, uc001tbp.1, uc001tbp.2, uc001tbp.3, uc001tbp.4
UCSC ID: uc001tbp.4
RefSeq Accession: NM_133505
Protein: P07585 (aka PGS2_HUMAN)
CCDS: CCDS9041.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene DCN:
csc-dys (Congenital Stromal Corneal Dystrophy)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.