Human Gene CD36 (ENST00000432207.5) Description and Page Index
  Description: Homo sapiens CD36 molecule (CD36), transcript variant 5, mRNA. (from RefSeq NM_001127444)
RefSeq Summary (NM_001127443): The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014].
Gencode Transcript: ENST00000432207.5
Gencode Gene: ENSG00000135218.19
Transcript (Including UTRs)
   Position: hg38 chr7:80,646,329-80,674,416 Size: 28,088 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr7:80,646,741-80,674,147 Size: 27,407 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:80,646,329-80,674,416)mRNA (may differ from genome)Protein (472 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CD36_HUMAN
DESCRIPTION: RecName: Full=Platelet glycoprotein 4; AltName: Full=Fatty acid translocase; Short=FAT; AltName: Full=Glycoprotein IIIb; Short=GPIIIB; AltName: Full=Leukocyte differentiation antigen CD36; AltName: Full=PAS IV; AltName: Full=PAS-4; AltName: Full=Platelet collagen receptor; AltName: Full=Platelet glycoprotein IV; Short=GPIV; AltName: Full=Thrombospondin receptor; AltName: CD_antigen=CD36;
FUNCTION: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects.
SUBUNIT: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
PTM: N-glycosylated and O-glycosylated with a ratio of 2:1.
POLYMORPHISM: Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIM:611162].
DISEASE: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
DISEASE: Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].
SIMILARITY: Belongs to the CD36 family.
SEQUENCE CAUTION: Sequence=AAM14636.2; Type=Frameshift; Positions=53;
WEB RESOURCE: Name=Wikipedia; Note=CD36 entry; URL="http://en.wikipedia.org/wiki/CD36";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD36";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cd36/";

-  MalaCards Disease Associations
  MalaCards Gene Search: CD36
Diseases sorted by gene-association score: platelet glycoprotein iv deficiency* (1355), malaria* (627), coronary heart disease 7* (594), keloids (18), hypertrophic scars (18), chancroid (18), primary optic atrophy (18), babesiosis (18), osteogenesis imperfecta, type i (17), osteogenesis imperfecta, type vii (13), osteogenesis imperfecta, type v (13), gingival overgrowth (11), osteogenesis imperfecta, type ii (11), plasmodium falciparum malaria (11), osteofibrous dysplasia (11), perinatally lethal osteogenesis imperfecta (11), newcastle disease (10), odontogenic myxoma (10), caffey disease (10), reflex sympathetic dystrophy (10), interstitial keratitis (10), hypertensive heart disease (10), gingival fibromatosis (9), ocular cicatricial pemphigoid (9), farmer's lung (9), achondrogenesis, type ii or hypochondrogenesis (9), eosinophilic granuloma (9), osteogenesis imperfecta, type iv (8), osteogenesis imperfecta, type iii (8), bruck syndrome (8), fasting hypoglycemia (8), osteochondrosis (8), short stature, brachydactyly, intellectual developmental disability, and seizures (8), myxofibrosarcoma (7), osteogenesis imperfecta (7), renal fibrosis (7), ehlers-danlos syndrome, classic type (7), griscelli syndrome, type 3 (7), crest syndrome (6), dermatographia (6), myd88 deficiency (6), chronic graft versus host disease (6), irak4 deficiency (6), marfan syndrome (6), thrombasthenia (5), osteoporosis (5), cribriform carcinoma (5), gray platelet syndrome (4), heart disease (2), differentiated thyroid carcinoma (1), pulmonary fibrosis, idiopathic (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 256.29 RPKM in Adipose - Visceral (Omentum)
Total median expression: 1059.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.00120-0.167 Picture PostScript Text
3' UTR -47.20269-0.175 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002159 - CD36
IPR005428 - CD36_antigen

Pfam Domains:
PF01130 - CD36 family

ModBase Predicted Comparative 3D Structure on P16671
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001540 beta-amyloid binding
GO:0005041 low-density lipoprotein receptor activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0008035 high-density lipoprotein particle binding
GO:0008289 lipid binding
GO:0030169 low-density lipoprotein particle binding
GO:0035325 Toll-like receptor binding
GO:0050431 transforming growth factor beta binding
GO:0070053 thrombospondin receptor activity
GO:0070892 lipoteichoic acid receptor activity
GO:0071813 lipoprotein particle binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002224 toll-like receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002576 platelet degranulation
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006629 lipid metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0006910 phagocytosis, recognition
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007263 nitric oxide mediated signal transduction
GO:0007596 blood coagulation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010886 positive regulation of cholesterol storage
GO:0010942 positive regulation of cell death
GO:0019216 regulation of lipid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019915 lipid storage
GO:0019934 cGMP-mediated signaling
GO:0030194 positive regulation of blood coagulation
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0031623 receptor internalization
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033993 response to lipid
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034197 triglyceride transport
GO:0034381 plasma lipoprotein particle clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0035634 response to stilbenoid
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042308 negative regulation of protein import into nucleus
GO:0042953 lipoprotein transport
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277 apoptotic cell clearance
GO:0043312 neutrophil degranulation
GO:0043410 positive regulation of MAPK cascade
GO:0043497 regulation of protein heterodimerization activity
GO:0044130 negative regulation of growth of symbiont in host
GO:0044539 long-chain fatty acid import
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0050702 interleukin-1 beta secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050830 defense response to Gram-positive bacterium
GO:0050892 intestinal absorption
GO:0050909 sensory perception of taste
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0055096 low-density lipoprotein particle mediated signaling
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060907 positive regulation of macrophage cytokine production
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070508 cholesterol import
GO:0070542 response to fatty acid
GO:0070543 response to linoleic acid
GO:0071221 cellular response to bacterial lipopeptide
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071447 cellular response to hydroperoxide
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0097009 energy homeostasis
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1904646 cellular response to beta-amyloid
GO:1990000 amyloid fibril formation
GO:2000121 regulation of removal of superoxide radicals
GO:2000334 positive regulation of blood microparticle formation
GO:2000379 positive regulation of reactive oxygen species metabolic process

Cellular Component:
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030666 endocytic vesicle membrane
GO:0031092 platelet alpha granule membrane
GO:0031526 brush border membrane
GO:0035579 specific granule membrane
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0045335 phagocytic vesicle


-  Descriptions from all associated GenBank mRNAs
  AK096858 - Homo sapiens cDNA FLJ39539 fis, clone PUAEN2008228, highly similar to Platelet glycoprotein 4.
AK129899 - Homo sapiens cDNA FLJ26389 fis, clone HRT07345, highly similar to Platelet glycoprotein IV.
AK300101 - Homo sapiens cDNA FLJ56151 complete cds, highly similar to Platelet glycoprotein 4.
AK312920 - Homo sapiens cDNA, FLJ93369, highly similar to Homo sapiens CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36), mRNA.
BC008406 - Homo sapiens CD36 molecule (thrombospondin receptor), mRNA (cDNA clone MGC:14530 IMAGE:4244251), complete cds.
M98398 - Human antigen CD36 (clone 13) mRNA, complete cds.
M98399 - Human antigen CD36 (clone 21) mRNA, complete cds.
M24795 - Human CD36 antigen mRNA, complete cds.
S67532 - CD36=glycoprotein GPIIIb/GPIV [human, platelet, mRNA, 1647 nt].
L06850 - Human antigen CD36 mRNA, complete cds.
AX419922 - Sequence 259 from Patent WO0198537.
HM217021 - Homo sapiens cell-line HDR platelet glycoprotein IV variant (CD36) mRNA, complete cds.
HM217022 - Homo sapiens cell-line YSQ platelet glycoprotein IV variant (CD36) mRNA, complete cds.
HM217024 - Homo sapiens cell-line ZQG platelet glycoprotein IV variant (CD36) mRNA, complete cds.
HM217025 - Homo sapiens cell-line WGM platelet glycoprotein IV variant (CD36) mRNA, complete cds.
HM217020 - Homo sapiens cell-line CWS platelet glycoprotein IV variant (CD36) mRNA, complete cds.
HM217023 - Homo sapiens cell-line CWS platelet glycoprotein IV variant (CD36) mRNA, complete cds.
HM217026 - Homo sapiens cell-line ZZH platelet glycoprotein IV variant (CD36) mRNA, complete cds.
JD303785 - Sequence 284809 from Patent EP1572962.
JD237963 - Sequence 218987 from Patent EP1572962.
CU678951 - Synthetic construct Homo sapiens gateway clone IMAGE:100023406 5' read CD36 mRNA.
KU177961 - Homo sapiens CD36 molecule isoform 1 (CD36) mRNA, partial cds.
KU177962 - Homo sapiens CD36 molecule isoform 2 (CD36) mRNA, complete cds, alternatively spliced.
KU177963 - Homo sapiens CD36 molecule isoform 3 (CD36) mRNA, complete cds, alternatively spliced.
AB590184 - Synthetic construct DNA, clone: pFN21AE1348, Homo sapiens CD36 gene for CD36 molecule, without stop codon, in Flexi system.
DQ896314 - Synthetic construct Homo sapiens clone IMAGE:100010774; FLH193194.01L; RZPDo839D0968D CD36 molecule (thrombospondin receptor) (CD36) gene, encodes complete protein.
DQ893062 - Synthetic construct clone IMAGE:100005692; FLH193198.01X; RZPDo839D0978D CD36 molecule (thrombospondin receptor) (CD36) gene, encodes complete protein.
KJ896567 - Synthetic construct Homo sapiens clone ccsbBroadEn_05961 CD36 gene, encodes complete protein.
KR710353 - Synthetic construct Homo sapiens clone CCSBHm_00011786 CD36 (CD36) mRNA, encodes complete protein.
KR710354 - Synthetic construct Homo sapiens clone CCSBHm_00011788 CD36 (CD36) mRNA, encodes complete protein.
KR710355 - Synthetic construct Homo sapiens clone CCSBHm_00011789 CD36 (CD36) mRNA, encodes complete protein.
KR710356 - Synthetic construct Homo sapiens clone CCSBHm_00011792 CD36 (CD36) mRNA, encodes complete protein.
AK057690 - Homo sapiens cDNA FLJ33128 fis, clone TRACH2001596, weakly similar to H.sapiens of CD36 gene.
S67044 - CD36=collagen type I/thrombospondin receptor {one exon} [human, mRNA Partial, 369 nt].
CR749465 - Homo sapiens mRNA; cDNA DKFZp313K0116 (from clone DKFZp313K0116).
FW340060 - Screening.
JD025535 - Sequence 6559 from Patent EP1572962.
JD030122 - Sequence 11146 from Patent EP1572962.
S60719 - 85 kda protein {3' region, clone 32a} [human, adriamycin-resistant tumor cells, K562/ADM, mRNA Partial, 195 nt].
S60720 - 85 kda protein {3' region, clone C-3} [human, adriamycin-resistant tumor cells, K562/ADM, mRNA Partial, 660 nt].
JD285107 - Sequence 266131 from Patent EP1572962.
JD277083 - Sequence 258107 from Patent EP1572962.
JD296254 - Sequence 277278 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03320 - PPAR signaling pathway
hsa04512 - ECM-receptor interaction
hsa04640 - Hematopoietic cell lineage
hsa04920 - Adipocytokine signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_tsp1Pathway - TSP-1 Induced Apoptosis in Microvascular Endothelial Cell

Reactome (by CSHL, EBI, and GO)

Protein P16671 (Reactome details) participates in the following event(s):

R-HSA-2187264 Platelet glycoprotein IV (CD36) binds ligands
R-HSA-2559464 TLR6/2 ligand associates with CD14 and CD36 within lipid rafts
R-HSA-168950 TLR6:TLR2 is recruited to ligand:CD14:CD36
R-HSA-8869667 oxLDL:CD36 binds TLR4:TLR6
R-HSA-481044 Surface deployment of platelet alpha granule membrane components
R-HSA-1236958 Interaction of particulate antigens with dendritic cell receptors
R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-1236956 Engulfment of particulate antigen into phagocytic vesicle
R-HSA-2201316 Activated TLR2/4 interacts with MAL(TIRAP)
R-HSA-166072 MyD88 forms a complex with MAL:activated TLR2/4
R-HSA-2201322 MAL is phosphorylated by BTK
R-HSA-2559414 Activated TLR2/4:MAL interacts with BTK
R-HSA-937079 MyD88 oligomerization within the complex of activated TLR:Mal:MyD88
R-HSA-166082 IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex
R-HSA-937022 IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal
R-HSA-166091 IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex
R-HSA-166362 Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex
R-HSA-2262775 Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex
R-HSA-166286 Multiple IRAK1 autophosphorylation steps
R-HSA-166284 Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
R-HSA-166119 First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
R-HSA-166363 TRAF6 binds to hp- IRAK1
R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex
R-HSA-2262777 TRAF6 binds to p-IRAK2
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-1989781 PPARA activates gene expression
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-114608 Platelet degranulation
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-6798695 Neutrophil degranulation
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-1266738 Developmental Biology
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-449147 Signaling by Interleukins
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-168249 Innate Immune System
R-HSA-5653656 Vesicle-mediated transport
R-HSA-556833 Metabolism of lipids
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-168256 Immune System
R-HSA-1430728 Metabolism
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-109582 Hemostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5602358 Diseases associated with the TLR signaling cascade
R-HSA-5260271 Diseases of Immune System
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: CD36_HUMAN, GP3B, GP4, NM_001127444, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5, uc003uhg.1, uc003uhg.2, uc003uhg.3, uc003uhg.4, uc003uhg.5
UCSC ID: uc003uhg.5
RefSeq Accession: NM_001127443
Protein: P16671 (aka CD36_HUMAN)
CCDS: CCDS34673.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.