Human Gene LRRC8B (ENST00000439853.6) from GENCODE V38
  Description: Membrane; Multi-pass membrane protein (Potential). (from UniProt Q6P9F7)
Gencode Transcript: ENST00000439853.6
Gencode Gene: ENSG00000197147.15
Transcript (Including UTRs)
   Position: hg38 chr1:89,524,829-89,593,366 Size: 68,538 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr1:89,582,651-89,592,771 Size: 10,121 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:89,524,829-89,593,366)mRNA (may differ from genome)Protein (731 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 8B; AltName: Full=T-cell activation leucine repeat-rich protein; Short=TA-LRRP;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Contains 13 LRR (leucine-rich) repeats.
SEQUENCE CAUTION: Sequence=BAA13220.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.20 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 150.82 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -154.80434-0.357 Picture PostScript Text
3' UTR -189.80595-0.319 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR021040 - LRR_protein-8_N

Pfam Domains:
PF12534 - Pannexin-like TM region of LRRC8
PF00560 - Leucine Rich Repeat

ModBase Predicted Comparative 3D Structure on Q6P9F7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005225 volume-sensitive anion channel activity
GO:0005515 protein binding

Biological Process:
GO:0006811 ion transport
GO:0006884 cell volume homeostasis
GO:0007165 signal transduction
GO:0015698 inorganic anion transport
GO:0055085 transmembrane transport
GO:0098656 anion transmembrane transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034702 ion channel complex

-  Descriptions from all associated GenBank mRNAs
  BC060782 - Homo sapiens leucine rich repeat containing 8 family, member B, mRNA (cDNA clone MGC:71558 IMAGE:5298560), complete cds.
GQ900915 - Homo sapiens clone HEL-T-27 epididymis secretory sperm binding protein mRNA, complete cds.
BC030607 - Homo sapiens leucine rich repeat containing 8 family, member B, mRNA (cDNA clone MGC:26970 IMAGE:4824652), complete cds.
D86984 - Homo sapiens KIAA0231 mRNA for KIAA0231 protein.
AF385436 - Homo sapiens T-cell activation leucine repeat-rich protein mRNA, complete cds.
JD266185 - Sequence 247209 from Patent EP1572962.
AY640232 - Homo sapiens HSD-43 mRNA, complete cds.
JD553884 - Sequence 534908 from Patent EP1572962.
CU688940 - Synthetic construct Homo sapiens gateway clone IMAGE:100020099 5' read LRRC8B mRNA.
AB384447 - Synthetic construct DNA, clone: pF1KA0231, Homo sapiens LRRC8B gene for leucine-rich repeat-containing protein 8B, complete cds, without stop codon, in Flexi system.
KJ898498 - Synthetic construct Homo sapiens clone ccsbBroadEn_07892 LRRC8B gene, encodes complete protein.
GQ891292 - Homo sapiens clone HEL-S-15a epididymis secretory sperm binding protein mRNA, complete cds.
BC037831 - Homo sapiens leucine rich repeat containing 8 family, member B, mRNA (cDNA clone IMAGE:4812407), complete cds.
JD101870 - Sequence 82894 from Patent EP1572962.
JD481194 - Sequence 462218 from Patent EP1572962.
JD471784 - Sequence 452808 from Patent EP1572962.
JD380620 - Sequence 361644 from Patent EP1572962.
JD380621 - Sequence 361645 from Patent EP1572962.
JD288981 - Sequence 270005 from Patent EP1572962.
JD522412 - Sequence 503436 from Patent EP1572962.
JD320079 - Sequence 301103 from Patent EP1572962.
JD375442 - Sequence 356466 from Patent EP1572962.
JD080429 - Sequence 61453 from Patent EP1572962.
JD159038 - Sequence 140062 from Patent EP1572962.
JD275770 - Sequence 256794 from Patent EP1572962.
JD208844 - Sequence 189868 from Patent EP1572962.
JD119101 - Sequence 100125 from Patent EP1572962.
JD278352 - Sequence 259376 from Patent EP1572962.
JD144619 - Sequence 125643 from Patent EP1572962.
JD283339 - Sequence 264363 from Patent EP1572962.
JD135507 - Sequence 116531 from Patent EP1572962.
JD135506 - Sequence 116530 from Patent EP1572962.
JD497595 - Sequence 478619 from Patent EP1572962.
JD238415 - Sequence 219439 from Patent EP1572962.
JD047733 - Sequence 28757 from Patent EP1572962.
JD472284 - Sequence 453308 from Patent EP1572962.
JD108887 - Sequence 89911 from Patent EP1572962.
JD458036 - Sequence 439060 from Patent EP1572962.
JD176561 - Sequence 157585 from Patent EP1572962.
JD066825 - Sequence 47849 from Patent EP1572962.
JD184209 - Sequence 165233 from Patent EP1572962.
JD093092 - Sequence 74116 from Patent EP1572962.
JD561446 - Sequence 542470 from Patent EP1572962.
JD282015 - Sequence 263039 from Patent EP1572962.
JD269727 - Sequence 250751 from Patent EP1572962.
JD189890 - Sequence 170914 from Patent EP1572962.
AY358112 - Homo sapiens clone DNA161005 ITLT6413 (UNQ6413) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6P9F7 (Reactome details) participates in the following event(s):

R-HSA-8941543 VRAC heteromer transports I-, Cl- from cytosol to extracellular region
R-HSA-5223345 Miscellaneous transport and binding events
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: BC060782, D3DT28, ENST00000439853.1, ENST00000439853.2, ENST00000439853.3, ENST00000439853.4, ENST00000439853.5, KIAA0231, LRC8B_HUMAN, Q6P9F7, Q6UY21, Q8N106, Q92627, uc057iep.1, uc057iep.2, UNQ6413/PRO21207
UCSC ID: ENST00000439853.6
RefSeq Accession: NM_001369817
Protein: Q6P9F7 (aka LRC8B_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.