Human Gene AGTRAP (ENST00000452018.6) Description and Page Index
Description: Homo sapiens angiotensin II receptor associated protein (AGTRAP), transcript variant 4, mRNA. (from RefSeq NM_001040196) RefSeq Summary (NM_001040196): This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000452018.6 Gencode Gene: ENSG00000177674.16 Transcript (Including UTRs) Position: hg38 chr1:11,736,173-11,750,409 Size: 14,237 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr1:11,736,209-11,750,104 Size: 13,896 Coding Exon Count: 6
ID:ATRAP_HUMAN DESCRIPTION: RecName: Full=Type-1 angiotensin II receptor-associated protein; AltName: Full=AT1 receptor-associated protein; FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. SUBUNIT: Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1. INTERACTION: Q96AL5:PBX3; NbExp=3; IntAct=EBI-741181, EBI-741171; Q9UKF7:PITPNC1; NbExp=3; IntAct=EBI-741181, EBI-749241; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. TISSUE SPECIFICITY: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. SEQUENCE CAUTION: Sequence=CAI15876.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/agtrap/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06396 - Angiotensin II, type I receptor-associated protein (AGTRAP)
ModBase Predicted Comparative 3D Structure on Q6RW13
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.