Human Gene AGTRAP (ENST00000452018.6) Description and Page Index
  Description: Homo sapiens angiotensin II receptor associated protein (AGTRAP), transcript variant 4, mRNA. (from RefSeq NM_001040196)
RefSeq Summary (NM_001040196): This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000452018.6
Gencode Gene: ENSG00000177674.16
Transcript (Including UTRs)
   Position: hg38 chr1:11,736,173-11,750,409 Size: 14,237 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr1:11,736,209-11,750,104 Size: 13,896 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:11,736,173-11,750,409)mRNA (may differ from genome)Protein (155 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ATRAP_HUMAN
DESCRIPTION: RecName: Full=Type-1 angiotensin II receptor-associated protein; AltName: Full=AT1 receptor-associated protein;
FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
SUBUNIT: Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.
INTERACTION: Q96AL5:PBX3; NbExp=3; IntAct=EBI-741181, EBI-741171; Q9UKF7:PITPNC1; NbExp=3; IntAct=EBI-741181, EBI-749241;
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
TISSUE SPECIFICITY: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
SEQUENCE CAUTION: Sequence=CAI15876.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/agtrap/";

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 82.61 RPKM in Whole Blood
Total median expression: 625.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.6036-0.433 Picture PostScript Text
3' UTR -117.90305-0.387 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009436 - Angiotensin_II_typ1_rcpt-assoc

Pfam Domains:
PF06396 - Angiotensin II, type I receptor-associated protein (AGTRAP)

ModBase Predicted Comparative 3D Structure on Q6RW13
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004945 angiotensin type II receptor activity
GO:0005515 protein binding

Biological Process:
GO:0001666 response to hypoxia
GO:0008217 regulation of blood pressure
GO:0038166 angiotensin-activated signaling pathway

Cellular Component:
GO:0000139 Golgi membrane
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK290042 - Homo sapiens cDNA FLJ75423 complete cds, highly similar to Homo sapiens angiotensin II receptor-associated protein (AGTRAP), mRNA.
BC017328 - Homo sapiens angiotensin II receptor-associated protein, mRNA (cDNA clone MGC:29646 IMAGE:4546585), complete cds.
AF312374 - Homo sapiens AGTRAP protein mRNA, complete cds.
E09415 - cDNA encoding a polypeptide obtained from human gliablastoma cells.
BC011946 - Homo sapiens cDNA clone IMAGE:3857985.
JD422171 - Sequence 403195 from Patent EP1572962.
KJ899301 - Synthetic construct Homo sapiens clone ccsbBroadEn_08695 AGTRAP gene, encodes complete protein.
AB528670 - Synthetic construct DNA, clone: pF1KB6809, Homo sapiens AGTRAP gene for angiotensin II receptor-associated protein, without stop codon, in Flexi system.
DQ892619 - Synthetic construct clone IMAGE:100005249; FLH188371.01X; RZPDo839B0873D angiotensin II receptor-associated protein (AGTRAP) gene, encodes complete protein.
DQ895859 - Synthetic construct Homo sapiens clone IMAGE:100010319; FLH188367.01L; RZPDo839B0863D angiotensin II receptor-associated protein (AGTRAP) gene, encodes complete protein.
AF165187 - Homo sapiens ATRAP mRNA, complete cds.
E09414 - cDNA encoding a polypeptide obtained from human gliablastoma cells.
JD384878 - Sequence 365902 from Patent EP1572962.
JD308068 - Sequence 289092 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6RW13 (Reactome details) participates in the following event(s):

R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated
R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
R-HSA-6802932 Dissociation of BRAF/RAF fusion complex
R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A8MVQ5, ATRAP, ATRAP_HUMAN, NM_001040196, Q5SNV4, Q5SNV5, Q6RW13, Q96AC0, Q96PL4, Q9NRW9, uc001asu.1, uc001asu.2, uc001asu.3, uc001asu.4
UCSC ID: uc001asu.4
RefSeq Accession: NM_001040196
Protein: Q6RW13 (aka ATRAP_HUMAN)
CCDS: CCDS44056.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.